Potential inhibitory effect of geraniol isolated from lemongrass (Cymbopogon commutatus Stapf) on tilmicosin-induced oxidative stress in cardiac tissue
An experimental study has been conducted to investigate the efficacy of geraniol (GNL) isolated from lemomgrass in protecting against cardiac toxicity induced by tilmicosin (TIL) in albino mice. Compared to TIL-treated mice, those supplemented with GNL had a thicker left ventricular wall and a smaller ventricular cavity. Studies of TIL animals treated with GNL showed that their cardiomyocytes had markedly changed in diameter and volume, along with a reduction in numerical density. After TIL induction, animals showed a significant increase in the protein expression of TGF-β1, TNF-α, nuclear factor kappa B (NF-kB), by 81.81, 73.75 and 66.67%, respectively, and hypertrophy marker proteins ANP, BNP, and calcineurin with respective percentages of 40, 33.34 and 42.34%. Interestingly, GNL significantly decreased the TGF-β1, TNF-α, NF-kB, ANP, BNP, and calcineurin levels by 60.94, 65.13, 52.37, 49.73, 44.18 and 36.84%, respectively. As observed from histopathology and Masson's trichrome staining, supplementation with GNL could rescue TIL-induced cardiac hypertrophy. According to these results, GNL may protect the heart by reducing hypertrophy in mice and modulating biomarkers of fibrosis and apoptosis.
Medienart: |
E-Artikel |
---|
Erscheinungsjahr: |
2024 |
---|---|
Erschienen: |
2024 |
Enthalten in: |
Zur Gesamtaufnahme - volume:38 |
---|---|
Enthalten in: |
Natural product research - 38(2024), 10 vom: 29. Apr., Seite 1652-1661 |
Sprache: |
Englisch |
---|
Beteiligte Personen: |
Ben Ammar, Rebai [VerfasserIn] |
---|
Links: |
---|
Anmerkungen: |
Date Completed 19.04.2024 Date Revised 19.04.2024 published: Print-Electronic Citation Status MEDLINE |
---|
doi: |
10.1080/14786419.2023.2215901 |
---|
funding: |
|
---|---|
Förderinstitution / Projekttitel: |
|
PPN (Katalog-ID): |
NLM357288777 |
---|
LEADER | 01000caa a22002652 4500 | ||
---|---|---|---|
001 | NLM357288777 | ||
003 | DE-627 | ||
005 | 20240419232034.0 | ||
007 | cr uuu---uuuuu | ||
008 | 231226s2024 xx |||||o 00| ||eng c | ||
024 | 7 | |a 10.1080/14786419.2023.2215901 |2 doi | |
028 | 5 | 2 | |a pubmed24n1380.xml |
035 | |a (DE-627)NLM357288777 | ||
035 | |a (NLM)37226502 | ||
040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
041 | |a eng | ||
100 | 1 | |a Ben Ammar, Rebai |e verfasserin |4 aut | |
245 | 1 | 0 | |a Potential inhibitory effect of geraniol isolated from lemongrass (Cymbopogon commutatus Stapf) on tilmicosin-induced oxidative stress in cardiac tissue |
264 | 1 | |c 2024 | |
336 | |a Text |b txt |2 rdacontent | ||
337 | |a ƒaComputermedien |b c |2 rdamedia | ||
338 | |a ƒa Online-Ressource |b cr |2 rdacarrier | ||
500 | |a Date Completed 19.04.2024 | ||
500 | |a Date Revised 19.04.2024 | ||
500 | |a published: Print-Electronic | ||
500 | |a Citation Status MEDLINE | ||
520 | |a An experimental study has been conducted to investigate the efficacy of geraniol (GNL) isolated from lemomgrass in protecting against cardiac toxicity induced by tilmicosin (TIL) in albino mice. Compared to TIL-treated mice, those supplemented with GNL had a thicker left ventricular wall and a smaller ventricular cavity. Studies of TIL animals treated with GNL showed that their cardiomyocytes had markedly changed in diameter and volume, along with a reduction in numerical density. After TIL induction, animals showed a significant increase in the protein expression of TGF-β1, TNF-α, nuclear factor kappa B (NF-kB), by 81.81, 73.75 and 66.67%, respectively, and hypertrophy marker proteins ANP, BNP, and calcineurin with respective percentages of 40, 33.34 and 42.34%. Interestingly, GNL significantly decreased the TGF-β1, TNF-α, NF-kB, ANP, BNP, and calcineurin levels by 60.94, 65.13, 52.37, 49.73, 44.18 and 36.84%, respectively. As observed from histopathology and Masson's trichrome staining, supplementation with GNL could rescue TIL-induced cardiac hypertrophy. According to these results, GNL may protect the heart by reducing hypertrophy in mice and modulating biomarkers of fibrosis and apoptosis | ||
650 | 4 | |a Journal Article | |
650 | 4 | |a Cardiac hypertrophy | |
650 | 4 | |a geraniol | |
650 | 4 | |a oxidative stress | |
650 | 4 | |a tilmicosin | |
650 | 7 | |a NF-kappa B |2 NLM | |
650 | 7 | |a Transforming Growth Factor beta1 |2 NLM | |
650 | 7 | |a geraniol |2 NLM | |
650 | 7 | |a L837108USY |2 NLM | |
650 | 7 | |a tilmicosin |2 NLM | |
650 | 7 | |a XL4103X2E3 |2 NLM | |
650 | 7 | |a Tumor Necrosis Factor-alpha |2 NLM | |
650 | 7 | |a Calcineurin |2 NLM | |
650 | 7 | |a EC 3.1.3.16 |2 NLM | |
650 | 7 | |a Acyclic Monoterpenes |2 NLM | |
650 | 7 | |a Tylosin |2 NLM | |
650 | 7 | |a YEF4JXN031 |2 NLM | |
700 | 1 | |a Abdulaziz Alamer, Sarah |e verfasserin |4 aut | |
700 | 1 | |a Elsayed Mohamed, Maged |e verfasserin |4 aut | |
700 | 1 | |a Althumairy, Duaa |e verfasserin |4 aut | |
700 | 1 | |a Y Al-Ramadan, Saeed |e verfasserin |4 aut | |
700 | 1 | |a Alfwuaires, Manal |e verfasserin |4 aut | |
700 | 1 | |a S Younis, Nancy |e verfasserin |4 aut | |
700 | 1 | |a A Althnaian, Thnaian |e verfasserin |4 aut | |
700 | 1 | |a R I H, Ibrahim |e verfasserin |4 aut | |
700 | 1 | |a Rajendran, Peramaiyan |e verfasserin |4 aut | |
773 | 0 | 8 | |i Enthalten in |t Natural product research |d 2003 |g 38(2024), 10 vom: 29. Apr., Seite 1652-1661 |w (DE-627)NLM124466303 |x 1478-6427 |7 nnns |
773 | 1 | 8 | |g volume:38 |g year:2024 |g number:10 |g day:29 |g month:04 |g pages:1652-1661 |
856 | 4 | 0 | |u http://dx.doi.org/10.1080/14786419.2023.2215901 |3 Volltext |
912 | |a GBV_USEFLAG_A | ||
912 | |a GBV_NLM | ||
951 | |a AR | ||
952 | |d 38 |j 2024 |e 10 |b 29 |c 04 |h 1652-1661 |