Association of a Polygenic Risk Score With Osteoporosis in People Living With HIV : The Swiss HIV Cohort Study
© The Author(s) 2023. Published by Oxford University Press on behalf of Infectious Diseases Society of America..
BACKGROUND: Bone mineral density (BMD) loss may be accelerated in people with HIV (PLWH). It is unknown whether a polygenic risk score (PRS) is associated with low BMD in PLWH.
METHODS: Swiss HIV Cohort Study participants of self-reported European descent underwent ≥2 per-protocol dual x-ray absorptiometry (DXA) measurements ≥2 years apart (2011-2020). Univariable and multivariable odds ratios (ORs) for DXA-defined osteoporosis were based on traditional and HIV-related risk factors and a genome-wide PRS built from 9413 single-nucleotide polymorphisms associated with low BMD in the general population. Controls were free from osteoporosis/osteopenia on all DXA measurements.
RESULTS: We included 438 participants: 149 with osteoporosis and 289 controls (median age, 53 years; 82% male, 95% with suppressed HIV RNA). Participants with unfavorable osteoporosis PRS (top vs bottom quintile) had univariable and multivariable-adjusted osteoporosis ORs of 4.76 (95% CI, 2.34-9.67) and 4.13 (1.86-9.18), respectively. For comparison, hepatitis C seropositivity, 5-year tenofovir disoproxil fumarate exposure, and parent history of hip fracture yielded univariable osteoporosis ORs of 2.26 (1.37-3.74), 1.84 (1.40-2.43), and 1.54 (0.82-2.9).
CONCLUSIONS: In PLWH in Switzerland, osteoporosis was independently associated with a BMD-associated PRS after adjustment for established risk factors, including exposure to tenofovir disoproxil fumarate.
| Medienart: |
E-Artikel |
|---|
| Erscheinungsjahr: |
2023 |
|---|---|
| Erschienen: |
2023 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:228 |
|---|---|
| Enthalten in: |
The Journal of infectious diseases - 228(2023), 6 vom: 15. Sept., Seite 742-750 |
| Sprache: |
Englisch |
|---|
| Beteiligte Personen: |
Schwenke, Johannes M [VerfasserIn] |
|---|
| Links: |
|---|
| Themen: |
99YXE507IL |
|---|
| Anmerkungen: |
Date Completed 18.09.2023 Date Revised 22.09.2023 published: Print Citation Status MEDLINE |
|---|
| doi: |
10.1093/infdis/jiad179 |
|---|
| funding: |
|
|---|---|
| Förderinstitution / Projekttitel: |
|
| PPN (Katalog-ID): |
NLM357280504 |
|---|
| LEADER | 01000naa a22002652 4500 | ||
|---|---|---|---|
| 001 | NLM357280504 | ||
| 003 | DE-627 | ||
| 005 | 20231226072237.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 231226s2023 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1093/infdis/jiad179 |2 doi | |
| 028 | 5 | 2 | |a pubmed24n1190.xml |
| 035 | |a (DE-627)NLM357280504 | ||
| 035 | |a (NLM)37225667 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
| 041 | |a eng | ||
| 100 | 1 | |a Schwenke, Johannes M |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Association of a Polygenic Risk Score With Osteoporosis in People Living With HIV |b The Swiss HIV Cohort Study |
| 264 | 1 | |c 2023 | |
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a ƒaComputermedien |b c |2 rdamedia | ||
| 338 | |a ƒa Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Date Completed 18.09.2023 | ||
| 500 | |a Date Revised 22.09.2023 | ||
| 500 | |a published: Print | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a © The Author(s) 2023. Published by Oxford University Press on behalf of Infectious Diseases Society of America. | ||
| 520 | |a BACKGROUND: Bone mineral density (BMD) loss may be accelerated in people with HIV (PLWH). It is unknown whether a polygenic risk score (PRS) is associated with low BMD in PLWH | ||
| 520 | |a METHODS: Swiss HIV Cohort Study participants of self-reported European descent underwent ≥2 per-protocol dual x-ray absorptiometry (DXA) measurements ≥2 years apart (2011-2020). Univariable and multivariable odds ratios (ORs) for DXA-defined osteoporosis were based on traditional and HIV-related risk factors and a genome-wide PRS built from 9413 single-nucleotide polymorphisms associated with low BMD in the general population. Controls were free from osteoporosis/osteopenia on all DXA measurements | ||
| 520 | |a RESULTS: We included 438 participants: 149 with osteoporosis and 289 controls (median age, 53 years; 82% male, 95% with suppressed HIV RNA). Participants with unfavorable osteoporosis PRS (top vs bottom quintile) had univariable and multivariable-adjusted osteoporosis ORs of 4.76 (95% CI, 2.34-9.67) and 4.13 (1.86-9.18), respectively. For comparison, hepatitis C seropositivity, 5-year tenofovir disoproxil fumarate exposure, and parent history of hip fracture yielded univariable osteoporosis ORs of 2.26 (1.37-3.74), 1.84 (1.40-2.43), and 1.54 (0.82-2.9) | ||
| 520 | |a CONCLUSIONS: In PLWH in Switzerland, osteoporosis was independently associated with a BMD-associated PRS after adjustment for established risk factors, including exposure to tenofovir disoproxil fumarate | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Research Support, Non-U.S. Gov't | |
| 650 | 4 | |a HIV infection | |
| 650 | 4 | |a aging | |
| 650 | 4 | |a low bone mineral density | |
| 650 | 4 | |a osteoporosis | |
| 650 | 4 | |a polygenic risk score | |
| 650 | 7 | |a Tenofovir |2 NLM | |
| 650 | 7 | |a 99YXE507IL |2 NLM | |
| 700 | 1 | |a Thorball, Christian W |e verfasserin |4 aut | |
| 700 | 1 | |a Schoepf, Isabella C |e verfasserin |4 aut | |
| 700 | 1 | |a Ryom, Lene |e verfasserin |4 aut | |
| 700 | 1 | |a Hasse, Barbara |e verfasserin |4 aut | |
| 700 | 1 | |a Lamy, Olivier |e verfasserin |4 aut | |
| 700 | 1 | |a Calmy, Alexandra |e verfasserin |4 aut | |
| 700 | 1 | |a Wandeler, Gilles |e verfasserin |4 aut | |
| 700 | 1 | |a Marzolini, Catia |e verfasserin |4 aut | |
| 700 | 1 | |a Kahlert, Christian R |e verfasserin |4 aut | |
| 700 | 1 | |a Bernasconi, Enos |e verfasserin |4 aut | |
| 700 | 1 | |a Kouyos, Roger D |e verfasserin |4 aut | |
| 700 | 1 | |a Günthard, Huldrych F |e verfasserin |4 aut | |
| 700 | 1 | |a Ledergerber, Bruno |e verfasserin |4 aut | |
| 700 | 1 | |a Fellay, Jacques |e verfasserin |4 aut | |
| 700 | 1 | |a Burkhalter, Felix |e verfasserin |4 aut | |
| 700 | 1 | |a Tarr, Philip E |e verfasserin |4 aut | |
| 700 | 0 | |a Swiss HIV Cohort Study |e verfasserin |4 aut | |
| 700 | 1 | |a Abela, I |e investigator |4 oth | |
| 700 | 1 | |a Aebi-Popp, K |e investigator |4 oth | |
| 700 | 1 | |a Anagnostopoulos, A |e investigator |4 oth | |
| 700 | 1 | |a Battegay, M |e investigator |4 oth | |
| 700 | 1 | |a Bernasconi, E |e investigator |4 oth | |
| 700 | 1 | |a Braun, D L |e investigator |4 oth | |
| 700 | 1 | |a Bucher, H C |e investigator |4 oth | |
| 700 | 1 | |a Calmy, A |e investigator |4 oth | |
| 700 | 1 | |a Cavassini, M |e investigator |4 oth | |
| 700 | 1 | |a Ciuffi, A |e investigator |4 oth | |
| 700 | 1 | |a Dollenmaier, G |e investigator |4 oth | |
| 700 | 1 | |a Egger, M |e investigator |4 oth | |
| 700 | 1 | |a Elzi, L |e investigator |4 oth | |
| 700 | 1 | |a Fehr, J |e investigator |4 oth | |
| 700 | 1 | |a Fellay, J |e investigator |4 oth | |
| 700 | 1 | |a Furrer, H |e investigator |4 oth | |
| 700 | 1 | |a Fux, C A |e investigator |4 oth | |
| 700 | 1 | |a Günthard, H F |e investigator |4 oth | |
| 700 | 1 | |a Hachfeld, A |e investigator |4 oth | |
| 700 | 1 | |a Haerry, D |e investigator |4 oth | |
| 700 | 1 | |a Hasse, B |e investigator |4 oth | |
| 700 | 1 | |a Hirsch, H H |e investigator |4 oth | |
| 700 | 1 | |a Hoffmann, M |e investigator |4 oth | |
| 700 | 1 | |a Hösli, I |e investigator |4 oth | |
| 700 | 1 | |a Huber, M |e investigator |4 oth | |
| 700 | 1 | |a Jackson-Perry, D |e investigator |4 oth | |
| 700 | 1 | |a Kahlert, C R |e investigator |4 oth | |
| 700 | 1 | |a Kaiser, L |e investigator |4 oth | |
| 700 | 1 | |a Keiser, O |e investigator |4 oth | |
| 700 | 1 | |a Klimkait, T |e investigator |4 oth | |
| 700 | 1 | |a Kouyos, R D |e investigator |4 oth | |
| 700 | 1 | |a Kovari, H |e investigator |4 oth | |
| 700 | 1 | |a Kusejko, K |e investigator |4 oth | |
| 700 | 1 | |a Labhardt, N |e investigator |4 oth | |
| 700 | 1 | |a Leuzinger, K |e investigator |4 oth | |
| 700 | 1 | |a Martinez de Tejada, B |e investigator |4 oth | |
| 700 | 1 | |a Marzolini, C |e investigator |4 oth | |
| 700 | 1 | |a Metzner, K J |e investigator |4 oth | |
| 700 | 1 | |a Müller, N |e investigator |4 oth | |
| 700 | 1 | |a Nemeth, J |e investigator |4 oth | |
| 700 | 1 | |a Nicca, D |e investigator |4 oth | |
| 700 | 1 | |a Notter, J |e investigator |4 oth | |
| 700 | 1 | |a Paioni, P |e investigator |4 oth | |
| 700 | 1 | |a Pantaleo, G |e investigator |4 oth | |
| 700 | 1 | |a Perreau, M |e investigator |4 oth | |
| 700 | 1 | |a Rauch, A |e investigator |4 oth | |
| 700 | 1 | |a Salazar-Vizcaya, L |e investigator |4 oth | |
| 700 | 1 | |a Schmid, P |e investigator |4 oth | |
| 700 | 1 | |a Speck, R |e investigator |4 oth | |
| 700 | 1 | |a Stöckle, M |e investigator |4 oth | |
| 700 | 1 | |a Tarr, P |e investigator |4 oth | |
| 700 | 1 | |a Trkola, A |e investigator |4 oth | |
| 700 | 1 | |a Wandeler, G |e investigator |4 oth | |
| 700 | 1 | |a Weisser, M |e investigator |4 oth | |
| 700 | 1 | |a Yerly, S |e investigator |4 oth | |
| 773 | 0 | 8 | |i Enthalten in |t The Journal of infectious diseases |d 1945 |g 228(2023), 6 vom: 15. Sept., Seite 742-750 |w (DE-627)NLM000005819 |x 1537-6613 |7 nnns |
| 773 | 1 | 8 | |g volume:228 |g year:2023 |g number:6 |g day:15 |g month:09 |g pages:742-750 |
| 856 | 4 | 0 | |u http://dx.doi.org/10.1093/infdis/jiad179 |3 Volltext |
| 912 | |a GBV_USEFLAG_A | ||
| 912 | |a GBV_NLM | ||
| 951 | |a AR | ||
| 952 | |d 228 |j 2023 |e 6 |b 15 |c 09 |h 742-750 | ||