The GENIE BPC NSCLC Cohort : A Real-World Repository Integrating Standardized Clinical and Genomic Data for 1,846 Patients with Non-Small Cell Lung Cancer
©2023 The Authors; Published by the American Association for Cancer Research..
PURPOSE: We describe the clinical and genomic landscape of the non-small cell lung cancer (NSCLC) cohort of the American Association for Cancer Research (AACR) Project Genomics Evidence Neoplasia Information Exchange (GENIE) Biopharma Collaborative (BPC).
EXPERIMENTAL DESIGN: A total of 1,846 patients with NSCLC whose tumors were sequenced from 2014 to 2018 at four institutions participating in AACR GENIE were randomly chosen for curation using the PRISSMM data model. Progression-free survival (PFS) and overall survival (OS) were estimated for patients treated with standard therapies.
RESULTS: In this cohort, 44% of tumors harbored a targetable oncogenic alteration, with EGFR (20%), KRAS G12C (13%), and oncogenic fusions (ALK, RET, and ROS1; 5%) as the most frequent. Median OS (mOS) on first-line platinum-based therapy without immunotherapy was 17.4 months [95% confidence interval (CI), 14.9-19.5 months]. For second-line therapies, mOS was 9.2 months (95% CI, 7.5-11.3 months) for immune checkpoint inhibitors (ICI) and 6.4 months (95% CI, 5.1-8.1 months) for docetaxel ± ramucirumab. In a subset of patients treated with ICI in the second-line or later setting, median RECIST PFS (2.5 months; 95% CI, 2.2-2.8) and median real-world PFS based on imaging reports (2.2 months; 95% CI, 1.7-2.6) were similar. In exploratory analysis of the impact of tumor mutational burden (TMB) on survival on ICI treatment in the second-line or higher setting, TMB z-score harmonized across gene panels was associated with improved OS (univariable HR, 0.85; P = 0.03; n = 247 patients).
CONCLUSIONS: The GENIE BPC cohort provides comprehensive clinicogenomic data for patients with NSCLC, which can improve understanding of real-world patient outcomes.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2023 |
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| Erschienen: |
2023 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:29 |
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| Enthalten in: |
Clinical cancer research : an official journal of the American Association for Cancer Research - 29(2023), 17 vom: 01. Sept., Seite 3418-3428 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Choudhury, Noura J [VerfasserIn] |
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| Links: |
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| Themen: |
Antineoplastic Agents, Immunological |
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| Anmerkungen: |
Date Completed 04.09.2023 Date Revised 25.11.2023 published: Print Citation Status MEDLINE |
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| doi: |
10.1158/1078-0432.CCR-23-0580 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM357262808 |
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| 100 | 1 | |a Choudhury, Noura J |e verfasserin |4 aut | |
| 245 | 1 | 4 | |a The GENIE BPC NSCLC Cohort |b A Real-World Repository Integrating Standardized Clinical and Genomic Data for 1,846 Patients with Non-Small Cell Lung Cancer |
| 264 | 1 | |c 2023 | |
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| 500 | |a Date Completed 04.09.2023 | ||
| 500 | |a Date Revised 25.11.2023 | ||
| 500 | |a published: Print | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a ©2023 The Authors; Published by the American Association for Cancer Research. | ||
| 520 | |a PURPOSE: We describe the clinical and genomic landscape of the non-small cell lung cancer (NSCLC) cohort of the American Association for Cancer Research (AACR) Project Genomics Evidence Neoplasia Information Exchange (GENIE) Biopharma Collaborative (BPC) | ||
| 520 | |a EXPERIMENTAL DESIGN: A total of 1,846 patients with NSCLC whose tumors were sequenced from 2014 to 2018 at four institutions participating in AACR GENIE were randomly chosen for curation using the PRISSMM data model. Progression-free survival (PFS) and overall survival (OS) were estimated for patients treated with standard therapies | ||
| 520 | |a RESULTS: In this cohort, 44% of tumors harbored a targetable oncogenic alteration, with EGFR (20%), KRAS G12C (13%), and oncogenic fusions (ALK, RET, and ROS1; 5%) as the most frequent. Median OS (mOS) on first-line platinum-based therapy without immunotherapy was 17.4 months [95% confidence interval (CI), 14.9-19.5 months]. For second-line therapies, mOS was 9.2 months (95% CI, 7.5-11.3 months) for immune checkpoint inhibitors (ICI) and 6.4 months (95% CI, 5.1-8.1 months) for docetaxel ± ramucirumab. In a subset of patients treated with ICI in the second-line or later setting, median RECIST PFS (2.5 months; 95% CI, 2.2-2.8) and median real-world PFS based on imaging reports (2.2 months; 95% CI, 1.7-2.6) were similar. In exploratory analysis of the impact of tumor mutational burden (TMB) on survival on ICI treatment in the second-line or higher setting, TMB z-score harmonized across gene panels was associated with improved OS (univariable HR, 0.85; P = 0.03; n = 247 patients) | ||
| 520 | |a CONCLUSIONS: The GENIE BPC cohort provides comprehensive clinicogenomic data for patients with NSCLC, which can improve understanding of real-world patient outcomes | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Research Support, Non-U.S. Gov't | |
| 650 | 4 | |a Research Support, N.I.H., Extramural | |
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| 650 | 7 | |a Antineoplastic Agents, Immunological |2 NLM | |
| 650 | 7 | |a Proto-Oncogene Proteins |2 NLM | |
| 700 | 1 | |a Lavery, Jessica A |e verfasserin |4 aut | |
| 700 | 1 | |a Brown, Samantha |e verfasserin |4 aut | |
| 700 | 1 | |a de Bruijn, Ino |e verfasserin |4 aut | |
| 700 | 1 | |a Jee, Justin |e verfasserin |4 aut | |
| 700 | 1 | |a Tran, Thinh Ngoc |e verfasserin |4 aut | |
| 700 | 1 | |a Rizvi, Hira |e verfasserin |4 aut | |
| 700 | 1 | |a Arbour, Kathryn C |e verfasserin |4 aut | |
| 700 | 1 | |a Whiting, Karissa |e verfasserin |4 aut | |
| 700 | 1 | |a Shen, Ronglai |e verfasserin |4 aut | |
| 700 | 1 | |a Hellmann, Matthew |e verfasserin |4 aut | |
| 700 | 1 | |a Bedard, Philippe L |e verfasserin |4 aut | |
| 700 | 1 | |a Yu, Celeste |e verfasserin |4 aut | |
| 700 | 1 | |a Leighl, Natasha |e verfasserin |4 aut | |
| 700 | 1 | |a LeNoue-Newton, Michele |e verfasserin |4 aut | |
| 700 | 1 | |a Micheel, Christine |e verfasserin |4 aut | |
| 700 | 1 | |a Warner, Jeremy L |e verfasserin |4 aut | |
| 700 | 1 | |a Ginsberg, Michelle S |e verfasserin |4 aut | |
| 700 | 1 | |a Plodkowski, Andrew |e verfasserin |4 aut | |
| 700 | 1 | |a Girshman, Jeffrey |e verfasserin |4 aut | |
| 700 | 1 | |a Sawan, Peter |e verfasserin |4 aut | |
| 700 | 1 | |a Pillai, Shirin |e verfasserin |4 aut | |
| 700 | 1 | |a Sweeney, Shawn M |e verfasserin |4 aut | |
| 700 | 1 | |a Kehl, Kenneth L |e verfasserin |4 aut | |
| 700 | 1 | |a Panageas, Katherine S |e verfasserin |4 aut | |
| 700 | 1 | |a Schultz, Nikolaus |e verfasserin |4 aut | |
| 700 | 1 | |a Schrag, Deborah |e verfasserin |4 aut | |
| 700 | 1 | |a Riely, Gregory J |e verfasserin |4 aut | |
| 700 | 0 | |a AACR GENIE BPC Core Team |e verfasserin |4 aut | |
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