Novel strategy of combined interstitial macrophage depletion with intravenous targeted therapy to ameliorate pulmonary fibrosis
© 2023 The Authors..
Idiopathic pulmonary fibrosis (IPF) is a severe interstitial lung disease with poor prognosis and high mortality rate. In the process of IPF, inflammatory dysregulation of macrophages and massive fibroblast aggregation and proliferation destroy alveoli, which cause pulmonary dysfunction, and ultimately lead to death due to respiratory failure. In the treatment of IPF, crossing biological barriers and delivering drugs to lung interstitium are the major challenges. In order to avoid the side effect of macrophages proliferation, we proposed, designed, and evaluated the strategy which combined macrophage depletion by intervaginal space injection and intravenous targeted therapy on bleomycin mouse model. We found that it inhibited pulmonary macrophages, reduced macrophage depletion in non-target organs, improved pulmonary drug targeting, impeded the progression of pulmonary fibrosis, and accelerated the recovery of pulmonary function. This combination therapeutic strategy shows good biosafety and efficacy, induces a targeted response, and is promising as a practical new clinical approach towards the treatment of pulmonary fibrosis.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2023 |
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| Erschienen: |
2023 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:20 |
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| Enthalten in: |
Materials today. Bio - 20(2023) vom: 08. Juni, Seite 100653 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Li, Zhongxian [VerfasserIn] |
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| Links: |
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| Themen: |
Combined strategy |
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| Anmerkungen: |
Date Revised 23.05.2023 published: Electronic-eCollection Citation Status PubMed-not-MEDLINE |
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| doi: |
10.1016/j.mtbio.2023.100653 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM357170318 |
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| 245 | 1 | 0 | |a Novel strategy of combined interstitial macrophage depletion with intravenous targeted therapy to ameliorate pulmonary fibrosis |
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| 500 | |a published: Electronic-eCollection | ||
| 500 | |a Citation Status PubMed-not-MEDLINE | ||
| 520 | |a © 2023 The Authors. | ||
| 520 | |a Idiopathic pulmonary fibrosis (IPF) is a severe interstitial lung disease with poor prognosis and high mortality rate. In the process of IPF, inflammatory dysregulation of macrophages and massive fibroblast aggregation and proliferation destroy alveoli, which cause pulmonary dysfunction, and ultimately lead to death due to respiratory failure. In the treatment of IPF, crossing biological barriers and delivering drugs to lung interstitium are the major challenges. In order to avoid the side effect of macrophages proliferation, we proposed, designed, and evaluated the strategy which combined macrophage depletion by intervaginal space injection and intravenous targeted therapy on bleomycin mouse model. We found that it inhibited pulmonary macrophages, reduced macrophage depletion in non-target organs, improved pulmonary drug targeting, impeded the progression of pulmonary fibrosis, and accelerated the recovery of pulmonary function. This combination therapeutic strategy shows good biosafety and efficacy, induces a targeted response, and is promising as a practical new clinical approach towards the treatment of pulmonary fibrosis | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Combined strategy | |
| 650 | 4 | |a Intervaginal space injection | |
| 650 | 4 | |a Macrophage depletion | |
| 650 | 4 | |a Pulmonary fibrosis | |
| 650 | 4 | |a Targeted therapy | |
| 700 | 1 | |a Zhang, Qiang |e verfasserin |4 aut | |
| 700 | 1 | |a Xiang, Jiawei |e verfasserin |4 aut | |
| 700 | 1 | |a Zhao, Mingyuan |e verfasserin |4 aut | |
| 700 | 1 | |a Meng, Yuan |e verfasserin |4 aut | |
| 700 | 1 | |a Hu, Xuhao |e verfasserin |4 aut | |
| 700 | 1 | |a Li, Tingting |e verfasserin |4 aut | |
| 700 | 1 | |a Nie, Yifeng |e verfasserin |4 aut | |
| 700 | 1 | |a Sun, Huizhen |e verfasserin |4 aut | |
| 700 | 1 | |a Yan, Tun |e verfasserin |4 aut | |
| 700 | 1 | |a Ao, Zhuo |e verfasserin |4 aut | |
| 700 | 1 | |a Han, Dong |e verfasserin |4 aut | |
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