Exosomes as cutting-edge therapeutics in various biomedical applications : An update on engineering, delivery, and preclinical studies
Copyright © 2023 Elsevier B.V. and Société Française de Biochimie et Biologie Moléculaire (SFBBM). All rights reserved..
Exosomes are cell-derived nanovesicles, circulating in different body fluids, and acting as an intercellular mechanism. They can be purified from culture media of different cell types and carry an enriched content of various protein and nucleic acid molecules originating from their parental cells. It was indicated that the exosomal cargo can mediate immune responses via many signaling pathways. Over recent years, the therapeutic effects of various exosome types were broadly investigated in many preclinical studies. Herein, we present an update on recent preclinical studies on exosomes as therapeutic and/or delivery agents for various applications. The exosome origin, structural modifications, natural or loaded active ingredients, size, and research outcomes were summarized for various diseases. Overall, the present article provides an overview of the latest exosome research interests and developments to clear the way for the clinical study design and application.
| Medienart: |
E-Artikel |
|---|
| Erscheinungsjahr: |
2023 |
|---|---|
| Erschienen: |
2023 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:213 |
|---|---|
| Enthalten in: |
Biochimie - 213(2023) vom: 15. Okt., Seite 139-167 |
| Sprache: |
Englisch |
|---|
| Beteiligte Personen: |
Mehryab, Fatemeh [VerfasserIn] |
|---|
| Links: |
|---|
| Themen: |
Drug delivery |
|---|
| Anmerkungen: |
Date Completed 25.09.2023 Date Revised 25.09.2023 published: Print-Electronic Citation Status MEDLINE |
|---|
| doi: |
10.1016/j.biochi.2023.05.010 |
|---|
| funding: |
|
|---|---|
| Förderinstitution / Projekttitel: |
|
| PPN (Katalog-ID): |
NLM357104498 |
|---|
| LEADER | 01000naa a22002652 4500 | ||
|---|---|---|---|
| 001 | NLM357104498 | ||
| 003 | DE-627 | ||
| 005 | 20231226071854.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 231226s2023 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1016/j.biochi.2023.05.010 |2 doi | |
| 028 | 5 | 2 | |a pubmed24n1190.xml |
| 035 | |a (DE-627)NLM357104498 | ||
| 035 | |a (NLM)37207937 | ||
| 035 | |a (PII)S0300-9084(23)00123-2 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
| 041 | |a eng | ||
| 100 | 1 | |a Mehryab, Fatemeh |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Exosomes as cutting-edge therapeutics in various biomedical applications |b An update on engineering, delivery, and preclinical studies |
| 264 | 1 | |c 2023 | |
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a ƒaComputermedien |b c |2 rdamedia | ||
| 338 | |a ƒa Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Date Completed 25.09.2023 | ||
| 500 | |a Date Revised 25.09.2023 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a Copyright © 2023 Elsevier B.V. and Société Française de Biochimie et Biologie Moléculaire (SFBBM). All rights reserved. | ||
| 520 | |a Exosomes are cell-derived nanovesicles, circulating in different body fluids, and acting as an intercellular mechanism. They can be purified from culture media of different cell types and carry an enriched content of various protein and nucleic acid molecules originating from their parental cells. It was indicated that the exosomal cargo can mediate immune responses via many signaling pathways. Over recent years, the therapeutic effects of various exosome types were broadly investigated in many preclinical studies. Herein, we present an update on recent preclinical studies on exosomes as therapeutic and/or delivery agents for various applications. The exosome origin, structural modifications, natural or loaded active ingredients, size, and research outcomes were summarized for various diseases. Overall, the present article provides an overview of the latest exosome research interests and developments to clear the way for the clinical study design and application | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Review | |
| 650 | 4 | |a Drug delivery | |
| 650 | 4 | |a Exosome | |
| 650 | 4 | |a Extracellular vesicle | |
| 650 | 4 | |a In vivo application | |
| 650 | 4 | |a Preclinical study | |
| 650 | 4 | |a Therapeutic | |
| 700 | 1 | |a Taghizadeh, Fatemeh |e verfasserin |4 aut | |
| 700 | 1 | |a Goshtasbi, Nazanin |e verfasserin |4 aut | |
| 700 | 1 | |a Merati, Faezeh |e verfasserin |4 aut | |
| 700 | 1 | |a Rabbani, Shahram |e verfasserin |4 aut | |
| 700 | 1 | |a Haeri, Azadeh |e verfasserin |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Biochimie |d 1971 |g 213(2023) vom: 15. Okt., Seite 139-167 |w (DE-627)NLM000014419 |x 1638-6183 |7 nnns |
| 773 | 1 | 8 | |g volume:213 |g year:2023 |g day:15 |g month:10 |g pages:139-167 |
| 856 | 4 | 0 | |u http://dx.doi.org/10.1016/j.biochi.2023.05.010 |3 Volltext |
| 912 | |a GBV_USEFLAG_A | ||
| 912 | |a GBV_NLM | ||
| 951 | |a AR | ||
| 952 | |d 213 |j 2023 |b 15 |c 10 |h 139-167 | ||