Resolved Psoriasis with Abundant Oleic Acid in Stratum Corneum Exhibits Lower T-Cell-Driven IL-17 Signature
Copyright © 2023 The Authors. Published by Elsevier Inc. All rights reserved..
Relapses of psoriasis involve T cells that stem and survive in the skin. Inherited from previous flares, the tissue-resident memory T cells are epidermal IL-17-producing CD8+ and IL-22-producing CD4+ T cells. Because the capacity of resident memory T cells to take in fatty acids is essential for their residence and function, the surface composition of fatty acids may affect underlying T-cell populations. In patients treated with biologics, we used gas chromatography/mass spectrometry to decipher the fatty acid composition in both resolved and nonlesional sites. Skin T cells were activated by OKT-3 in explants from the same body sites to perform bulk transcriptomic analysis (Nanostring). The fatty acid composition differed between skin from healthy donors and normal-looking skin of patients with psoriasis but not further between nonlesional and resolved skin. Patients in whom the resolved skin was rich in oleic acid had lower T-cell-driven IL-17 epidermal transcriptomic signature upon activation of T cells in skin explants. The skin lipid composition is linked with the functions of the underlying epidermal T cells. Testing the modulating effect of custom fatty acids on skin resident T cells could help with coming closer to disease oblivion in inflammatory skin diseases.
| Medienart: |
E-Artikel |
|---|
| Erscheinungsjahr: |
2023 |
|---|---|
| Erschienen: |
2023 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:143 |
|---|---|
| Enthalten in: |
The Journal of investigative dermatology - 143(2023), 11 vom: 01. Nov., Seite 2145-2152.e6 |
| Sprache: |
Englisch |
|---|
| Beteiligte Personen: |
El Mahi, Yasmin [VerfasserIn] |
|---|
| Links: |
|---|
| Themen: |
|---|
| Anmerkungen: |
Date Revised 21.10.2023 published: Print-Electronic Citation Status Publisher |
|---|
| doi: |
10.1016/j.jid.2023.04.021 |
|---|
| funding: |
|
|---|---|
| Förderinstitution / Projekttitel: |
|
| PPN (Katalog-ID): |
NLM35710319X |
|---|
| LEADER | 01000naa a22002652 4500 | ||
|---|---|---|---|
| 001 | NLM35710319X | ||
| 003 | DE-627 | ||
| 005 | 20231226071852.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 231226s2023 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1016/j.jid.2023.04.021 |2 doi | |
| 028 | 5 | 2 | |a pubmed24n1190.xml |
| 035 | |a (DE-627)NLM35710319X | ||
| 035 | |a (NLM)37207807 | ||
| 035 | |a (PII)S0022-202X(23)02067-5 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
| 041 | |a eng | ||
| 100 | 1 | |a El Mahi, Yasmin |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Resolved Psoriasis with Abundant Oleic Acid in Stratum Corneum Exhibits Lower T-Cell-Driven IL-17 Signature |
| 264 | 1 | |c 2023 | |
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a ƒaComputermedien |b c |2 rdamedia | ||
| 338 | |a ƒa Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Date Revised 21.10.2023 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status Publisher | ||
| 520 | |a Copyright © 2023 The Authors. Published by Elsevier Inc. All rights reserved. | ||
| 520 | |a Relapses of psoriasis involve T cells that stem and survive in the skin. Inherited from previous flares, the tissue-resident memory T cells are epidermal IL-17-producing CD8+ and IL-22-producing CD4+ T cells. Because the capacity of resident memory T cells to take in fatty acids is essential for their residence and function, the surface composition of fatty acids may affect underlying T-cell populations. In patients treated with biologics, we used gas chromatography/mass spectrometry to decipher the fatty acid composition in both resolved and nonlesional sites. Skin T cells were activated by OKT-3 in explants from the same body sites to perform bulk transcriptomic analysis (Nanostring). The fatty acid composition differed between skin from healthy donors and normal-looking skin of patients with psoriasis but not further between nonlesional and resolved skin. Patients in whom the resolved skin was rich in oleic acid had lower T-cell-driven IL-17 epidermal transcriptomic signature upon activation of T cells in skin explants. The skin lipid composition is linked with the functions of the underlying epidermal T cells. Testing the modulating effect of custom fatty acids on skin resident T cells could help with coming closer to disease oblivion in inflammatory skin diseases | ||
| 650 | 4 | |a Journal Article | |
| 700 | 1 | |a Varin, Alexis |e verfasserin |4 aut | |
| 700 | 1 | |a Vetter, Mathieu |e verfasserin |4 aut | |
| 700 | 1 | |a Dal Zuffo, Ludivine |e verfasserin |4 aut | |
| 700 | 1 | |a Mazzeo, Loïc |e verfasserin |4 aut | |
| 700 | 1 | |a Pais De Barros, Jean-Paul |e verfasserin |4 aut | |
| 700 | 1 | |a Aubin, François |e verfasserin |4 aut | |
| 700 | 1 | |a Saas, Philippe |e verfasserin |4 aut | |
| 700 | 1 | |a Gallais Sérézal, Irène |e verfasserin |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t The Journal of investigative dermatology |d 1945 |g 143(2023), 11 vom: 01. Nov., Seite 2145-2152.e6 |w (DE-627)NLM000018597 |x 1523-1747 |7 nnns |
| 773 | 1 | 8 | |g volume:143 |g year:2023 |g number:11 |g day:01 |g month:11 |g pages:2145-2152.e6 |
| 856 | 4 | 0 | |u http://dx.doi.org/10.1016/j.jid.2023.04.021 |3 Volltext |
| 912 | |a GBV_USEFLAG_A | ||
| 912 | |a GBV_NLM | ||
| 951 | |a AR | ||
| 952 | |d 143 |j 2023 |e 11 |b 01 |c 11 |h 2145-2152.e6 | ||