Autoimmune Diabetes From Childhood to Adulthood : The Role of Pancreatic Autoantibodies and HLA-DRB1 Genotype
© The Author(s) 2023. Published by Oxford University Press on behalf of the Endocrine Society. All rights reserved. For permissions, please e-mail: journals.permissionsoup.com..
CONTEXT: Autoimmune diabetes can develop at any age, but unlike early-onset diabetes, adult onset is less well documented. We aimed to compare, over a wide age range, the most reliable predictive biomarkers for this pathology: pancreatic-autoantibodies and HLA-DRB1 genotype.
METHODS: A retrospective study of 802 patients with diabetes (aged 11 months to 66 years) was conducted. Pancreatic autoantibodies at diagnosis: insulin autoantibodies (IAA), glutamate decarboxylase autoantibodies (GADA), islet tyrosine phosphatase 2 autoantibodies (IA2A), and zinc transporter-8 autoantibodies (ZnT8A) and HLA-DRB1 genotype were analyzed.
RESULTS: Compared with early-onset patients, adults had a lower frequency of multiple autoantibodies, with GADA being the most common. At early onset, IAA was the most frequent in those younger than 6 years and correlated inversely with age; GADA and ZnT8A correlated directly and IA2A remained stable.The absence of HLA-DRB1 risk genotype was associated with higher age at diabetes onset (27.5 years; interquartile range [IQR], 14.3-35.7), whereas the high-risk HLA-DR3/DR4 was significantly more common at lower age (11.9 years; IQR, 7.1-21.6). ZnT8A was associated with DR4/non-DR3 (odds ratio [OR], 1.91; 95% CI, 1.15-3.17), GADA with DR3/non-DR4 (OR, 2.97; 95% CI, 1.55-5.71), and IA2A with DR4/non-DR3 and DR3/DR4 (OR, 3.89; 95% CI, 2.28-6.64, and OR, 3.08; 95% CI, 1.83-5.18, respectively). No association of IAA with HLA-DRB1 was found.
CONCLUSION: Autoimmunity and HLA-DRB1 genotype are age-dependent biomarkers. Adult-onset autoimmune diabetes is associated with lower genetic risk and lower immune response to pancreatic islet cells compared with early-onset diabetes.
| Errataetall: |
ErratumIn: J Clin Endocrinol Metab. 2023 Oct 13;:. - PMID 37831551 |
|---|---|
| Medienart: |
E-Artikel |
| Erscheinungsjahr: |
2023 |
|---|---|
| Erschienen: |
2023 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:108 |
|---|---|
| Enthalten in: |
The Journal of clinical endocrinology and metabolism - 108(2023), 11 vom: 18. Okt., Seite e1341-e1346 |
| Sprache: |
Englisch |
|---|
| Beteiligte Personen: |
Urrutia, Inés [VerfasserIn] |
|---|
| Links: |
|---|
| Anmerkungen: |
Date Completed 27.11.2023 Date Revised 18.01.2024 published: Print ErratumIn: J Clin Endocrinol Metab. 2023 Oct 13;:. - PMID 37831551 Citation Status MEDLINE |
|---|
| doi: |
10.1210/clinem/dgad277 |
|---|
| funding: |
|
|---|---|
| Förderinstitution / Projekttitel: |
|
| PPN (Katalog-ID): |
NLM357099648 |
|---|
| LEADER | 01000caa a22002652 4500 | ||
|---|---|---|---|
| 001 | NLM357099648 | ||
| 003 | DE-627 | ||
| 005 | 20240118231847.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 231226s2023 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1210/clinem/dgad277 |2 doi | |
| 028 | 5 | 2 | |a pubmed24n1263.xml |
| 035 | |a (DE-627)NLM357099648 | ||
| 035 | |a (NLM)37207452 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
| 041 | |a eng | ||
| 100 | 1 | |a Urrutia, Inés |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Autoimmune Diabetes From Childhood to Adulthood |b The Role of Pancreatic Autoantibodies and HLA-DRB1 Genotype |
| 264 | 1 | |c 2023 | |
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a ƒaComputermedien |b c |2 rdamedia | ||
| 338 | |a ƒa Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Date Completed 27.11.2023 | ||
| 500 | |a Date Revised 18.01.2024 | ||
| 500 | |a published: Print | ||
| 500 | |a ErratumIn: J Clin Endocrinol Metab. 2023 Oct 13;:. - PMID 37831551 | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a © The Author(s) 2023. Published by Oxford University Press on behalf of the Endocrine Society. All rights reserved. For permissions, please e-mail: journals.permissionsoup.com. | ||
| 520 | |a CONTEXT: Autoimmune diabetes can develop at any age, but unlike early-onset diabetes, adult onset is less well documented. We aimed to compare, over a wide age range, the most reliable predictive biomarkers for this pathology: pancreatic-autoantibodies and HLA-DRB1 genotype | ||
| 520 | |a METHODS: A retrospective study of 802 patients with diabetes (aged 11 months to 66 years) was conducted. Pancreatic autoantibodies at diagnosis: insulin autoantibodies (IAA), glutamate decarboxylase autoantibodies (GADA), islet tyrosine phosphatase 2 autoantibodies (IA2A), and zinc transporter-8 autoantibodies (ZnT8A) and HLA-DRB1 genotype were analyzed | ||
| 520 | |a RESULTS: Compared with early-onset patients, adults had a lower frequency of multiple autoantibodies, with GADA being the most common. At early onset, IAA was the most frequent in those younger than 6 years and correlated inversely with age; GADA and ZnT8A correlated directly and IA2A remained stable.The absence of HLA-DRB1 risk genotype was associated with higher age at diabetes onset (27.5 years; interquartile range [IQR], 14.3-35.7), whereas the high-risk HLA-DR3/DR4 was significantly more common at lower age (11.9 years; IQR, 7.1-21.6). ZnT8A was associated with DR4/non-DR3 (odds ratio [OR], 1.91; 95% CI, 1.15-3.17), GADA with DR3/non-DR4 (OR, 2.97; 95% CI, 1.55-5.71), and IA2A with DR4/non-DR3 and DR3/DR4 (OR, 3.89; 95% CI, 2.28-6.64, and OR, 3.08; 95% CI, 1.83-5.18, respectively). No association of IAA with HLA-DRB1 was found | ||
| 520 | |a CONCLUSION: Autoimmunity and HLA-DRB1 genotype are age-dependent biomarkers. Adult-onset autoimmune diabetes is associated with lower genetic risk and lower immune response to pancreatic islet cells compared with early-onset diabetes | ||
| 650 | 4 | |a Comparative Study | |
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Research Support, Non-U.S. Gov't | |
| 650 | 4 | |a HLA-DRB1 genotype | |
| 650 | 4 | |a adult-onset diabetes | |
| 650 | 4 | |a autoimmune diabetes | |
| 650 | 4 | |a early-onset diabetes | |
| 650 | 4 | |a pancreatic-autoantibodies | |
| 650 | 7 | |a Autoantibodies |2 NLM | |
| 650 | 7 | |a Biomarkers |2 NLM | |
| 650 | 7 | |a Glutamate Decarboxylase |2 NLM | |
| 650 | 7 | |a EC 4.1.1.15 |2 NLM | |
| 650 | 7 | |a HLA-DR4 Antigen |2 NLM | |
| 650 | 7 | |a HLA-DRB1 Chains |2 NLM | |
| 650 | 7 | |a Pancreatic Hormones |2 NLM | |
| 700 | 1 | |a Martínez, Rosa |e verfasserin |4 aut | |
| 700 | 1 | |a Calvo, Begona |e verfasserin |4 aut | |
| 700 | 1 | |a Saso-Jiménez, Laura |e verfasserin |4 aut | |
| 700 | 1 | |a González, Pedro |e verfasserin |4 aut | |
| 700 | 1 | |a Fernández-Rubio, Elsa |e verfasserin |4 aut | |
| 700 | 1 | |a Martín-Nieto, Alicia |e verfasserin |4 aut | |
| 700 | 1 | |a Aguayo, Anibal |e verfasserin |4 aut | |
| 700 | 1 | |a Rica, Itxaso |e verfasserin |4 aut | |
| 700 | 1 | |a Gaztambide, Sonia |e verfasserin |4 aut | |
| 700 | 1 | |a Castano, Luis |e verfasserin |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t The Journal of clinical endocrinology and metabolism |d 1945 |g 108(2023), 11 vom: 18. Okt., Seite e1341-e1346 |w (DE-627)NLM00001821X |x 1945-7197 |7 nnns |
| 773 | 1 | 8 | |g volume:108 |g year:2023 |g number:11 |g day:18 |g month:10 |g pages:e1341-e1346 |
| 856 | 4 | 0 | |u http://dx.doi.org/10.1210/clinem/dgad277 |3 Volltext |
| 912 | |a GBV_USEFLAG_A | ||
| 912 | |a GBV_NLM | ||
| 951 | |a AR | ||
| 952 | |d 108 |j 2023 |e 11 |b 18 |c 10 |h e1341-e1346 | ||