Early atrial remodeling predicts the risk of cardiovascular events in patients with metabolic syndrome : a retrospective cohort study
© 2023 Wali, Wang, Li, Yang, Liu, Sama, Bai, Lee, Hidru, Yang and Xia..
Background: This study aims to assess the prevalence of atrial cardiomyopathy (ACM) in patients with new-onset metabolic syndrome (MetS) and investigate whether ACM could be a predictor of hospital admission for cardiovascular (CV) events.
Methods: Patients with MetS who were free of clinically proven atrial fibrillation and other CV diseases (CVDs) at baseline were included in the present study. The prevalence of ACM was compared between MetS patients with and without left ventricular hypertrophy (LVH). The time to first hospital admission for a CV event between subgroups was assessed using the Cox proportional hazard model.
Results: A total of 15,528 MetS patients were included in the final analysis. Overall, LVH patients accounted for 25.6% of all newly diagnosed MetS patients. ACM occurred in 52.9% of the cohort and involved 74.8% of LVH patients. Interestingly, a significant percentage of ACM patients (45.4%) experienced MetS without LVH. After 33.2 ± 20.6 months of follow-up, 7,468 (48.1%) patients had a history of readmission due to CV events. Multivariable Cox regression analysis revealed that ACM was associated with an increased risk of admission for CVDs in the MetS patients with LVH [hazard ratio (HR), 1.29; 95% confidence interval (CI), 1.142-1.458; P < 0.001]. Likewise, ACM was found to be independently associated with hospital readmission due to CVD-related events in MetS patients without LVH (HR, 1.175; 95% CI, 1.105-1.250; P < 0.001).
Conclusion: ACM is a marker of early myocardial remodeling and predicts hospitalization for CV events in patients with MetS.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2023 |
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| Erschienen: |
2023 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:10 |
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| Enthalten in: |
Frontiers in cardiovascular medicine - 10(2023) vom: 27., Seite 1162886 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Wali, Rohbaiz [VerfasserIn] |
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| Links: |
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| Themen: |
Atrial myopathy |
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| Anmerkungen: |
Date Revised 22.05.2023 published: Electronic-eCollection Citation Status PubMed-not-MEDLINE |
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| doi: |
10.3389/fcvm.2023.1162886 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM357086090 |
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| 245 | 1 | 0 | |a Early atrial remodeling predicts the risk of cardiovascular events in patients with metabolic syndrome |b a retrospective cohort study |
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| 520 | |a © 2023 Wali, Wang, Li, Yang, Liu, Sama, Bai, Lee, Hidru, Yang and Xia. | ||
| 520 | |a Background: This study aims to assess the prevalence of atrial cardiomyopathy (ACM) in patients with new-onset metabolic syndrome (MetS) and investigate whether ACM could be a predictor of hospital admission for cardiovascular (CV) events | ||
| 520 | |a Methods: Patients with MetS who were free of clinically proven atrial fibrillation and other CV diseases (CVDs) at baseline were included in the present study. The prevalence of ACM was compared between MetS patients with and without left ventricular hypertrophy (LVH). The time to first hospital admission for a CV event between subgroups was assessed using the Cox proportional hazard model | ||
| 520 | |a Results: A total of 15,528 MetS patients were included in the final analysis. Overall, LVH patients accounted for 25.6% of all newly diagnosed MetS patients. ACM occurred in 52.9% of the cohort and involved 74.8% of LVH patients. Interestingly, a significant percentage of ACM patients (45.4%) experienced MetS without LVH. After 33.2 ± 20.6 months of follow-up, 7,468 (48.1%) patients had a history of readmission due to CV events. Multivariable Cox regression analysis revealed that ACM was associated with an increased risk of admission for CVDs in the MetS patients with LVH [hazard ratio (HR), 1.29; 95% confidence interval (CI), 1.142-1.458; P < 0.001]. Likewise, ACM was found to be independently associated with hospital readmission due to CVD-related events in MetS patients without LVH (HR, 1.175; 95% CI, 1.105-1.250; P < 0.001) | ||
| 520 | |a Conclusion: ACM is a marker of early myocardial remodeling and predicts hospitalization for CV events in patients with MetS | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a atrial myopathy | |
| 650 | 4 | |a atrial remodeling | |
| 650 | 4 | |a cardiovascular diseases | |
| 650 | 4 | |a left ventricular hypertrophy | |
| 650 | 4 | |a metabolic syndrome | |
| 700 | 1 | |a Wang, Xinying |e verfasserin |4 aut | |
| 700 | 1 | |a Li, Chenglin |e verfasserin |4 aut | |
| 700 | 1 | |a Yang, Heng |e verfasserin |4 aut | |
| 700 | 1 | |a Liu, Fei |e verfasserin |4 aut | |
| 700 | 1 | |a Sama, Salah D |e verfasserin |4 aut | |
| 700 | 1 | |a Bai, Lan |e verfasserin |4 aut | |
| 700 | 1 | |a Lee, Sharen |e verfasserin |4 aut | |
| 700 | 1 | |a Hidru, Tesfaldet H |e verfasserin |4 aut | |
| 700 | 1 | |a Yang, Xiaolei |e verfasserin |4 aut | |
| 700 | 1 | |a Xia, Yunlong |e verfasserin |4 aut | |
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