Iron deficiency and its epigenetic effects on iron homeostasis
Copyright © 2023 Elsevier GmbH. All rights reserved..
Iron deficiency is a common micronutrient deficiency associated with metabolic changes in the levels of iron regulatory proteins, hepcidin and ferroportin. Studies have associated dysregulation of iron homeostasis to other secondary and life-threatening diseases including anaemia, neurodegeneration and metabolic diseases. Iron deficiency plays a critical role in epigenetic regulation by affecting the Fe2+/α-ketoglutarate-dependent demethylating enzymes, Ten Eleven Translocase 1-3 (TET 1-3) and Jumonji-C (JmjC) histone demethylase, which are involved in epigenetic erasure of the methylation marks on both DNA and histone tails, respectively. In this review, studies involving epigenetic effects of iron deficiency associated with dysregulation of TET 1-3 and JmjC histone demethylase enzyme activities on hepcidin/ferroportin axis are discussed.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2023 |
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| Erschienen: |
2023 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:78 |
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| Enthalten in: |
Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS) - 78(2023) vom: 25. Juli, Seite 127203 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Farida, Bashar [VerfasserIn] |
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| Links: |
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| Themen: |
E1UOL152H7 |
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| Anmerkungen: |
Date Completed 31.05.2023 Date Revised 31.05.2023 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1016/j.jtemb.2023.127203 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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NLM357039068 |
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| 520 | |a Copyright © 2023 Elsevier GmbH. All rights reserved. | ||
| 520 | |a Iron deficiency is a common micronutrient deficiency associated with metabolic changes in the levels of iron regulatory proteins, hepcidin and ferroportin. Studies have associated dysregulation of iron homeostasis to other secondary and life-threatening diseases including anaemia, neurodegeneration and metabolic diseases. Iron deficiency plays a critical role in epigenetic regulation by affecting the Fe2+/α-ketoglutarate-dependent demethylating enzymes, Ten Eleven Translocase 1-3 (TET 1-3) and Jumonji-C (JmjC) histone demethylase, which are involved in epigenetic erasure of the methylation marks on both DNA and histone tails, respectively. In this review, studies involving epigenetic effects of iron deficiency associated with dysregulation of TET 1-3 and JmjC histone demethylase enzyme activities on hepcidin/ferroportin axis are discussed | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Review | |
| 650 | 4 | |a Epigenetics | |
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| 650 | 4 | |a Hepcidin | |
| 650 | 4 | |a Iron deficiency | |
| 650 | 4 | |a Iron homeostasis | |
| 650 | 4 | |a JmjC histone demethylase | |
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| 700 | 1 | |a Bello, Muhammad B |e verfasserin |4 aut | |
| 700 | 1 | |a Abubakar, Murtala B |e verfasserin |4 aut | |
| 700 | 1 | |a Abbas, Abdullahi Y |e verfasserin |4 aut | |
| 700 | 1 | |a Imam, Mustapha U |e verfasserin |4 aut | |
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