Olfactory recovery following omicron variant infection : a psychophysical prospective case-control study with six-month follow up
OBJECTIVE: This study aimed to evaluate the recovery of olfactory function at six months in individuals infected with the coronavirus disease 2019 omicron variant, using psychophysical tests.
METHODS: A prospective case-control study that included severe acute respiratory syndrome coronavirus-2 patients infected in February and March 2022 was conducted. Patients underwent the Sniffin' Sticks test within 10 days of infection and again after at least 6 months. The olfactory scores were compared with those of a control group.
RESULTS: In all, 102 patients and 120 controls were enrolled in the study. At baseline, 26 patients (25.5 per cent) self-reported smell loss. The median threshold, discrimination and identification score was 33.6 (interquartile range, 12.5) for the cases and 36.5 (interquartile range, 4.38) for the controls (p < 0.001). Based on the threshold, discrimination and identification scores, 12 controls and 34 patients reported olfactory dysfunction (p < 0.001). Eighty cases underwent re-evaluation at six months; the median threshold, discrimination and identification score was 37.1 (interquartile range, 4.75) with no significant differences compared with the controls.
CONCLUSION: Six months after infection, the prevalence of olfactory dysfunction in patients did not differ significantly from the control population.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2023 |
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| Erschienen: |
2023 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:137 |
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| Enthalten in: |
The Journal of laryngology and otology - 137(2023), 12 vom: 11. Dez., Seite 1395-1400 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Vaira, Luigi Angelo [VerfasserIn] |
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| Links: |
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| Themen: |
Ageusia |
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| Anmerkungen: |
Date Completed 05.12.2023 Date Revised 05.12.2023 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1017/S0022215123000877 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM356970787 |
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| 100 | 1 | |a Vaira, Luigi Angelo |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Olfactory recovery following omicron variant infection |b a psychophysical prospective case-control study with six-month follow up |
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| 500 | |a Date Revised 05.12.2023 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a OBJECTIVE: This study aimed to evaluate the recovery of olfactory function at six months in individuals infected with the coronavirus disease 2019 omicron variant, using psychophysical tests | ||
| 520 | |a METHODS: A prospective case-control study that included severe acute respiratory syndrome coronavirus-2 patients infected in February and March 2022 was conducted. Patients underwent the Sniffin' Sticks test within 10 days of infection and again after at least 6 months. The olfactory scores were compared with those of a control group | ||
| 520 | |a RESULTS: In all, 102 patients and 120 controls were enrolled in the study. At baseline, 26 patients (25.5 per cent) self-reported smell loss. The median threshold, discrimination and identification score was 33.6 (interquartile range, 12.5) for the cases and 36.5 (interquartile range, 4.38) for the controls (p < 0.001). Based on the threshold, discrimination and identification scores, 12 controls and 34 patients reported olfactory dysfunction (p < 0.001). Eighty cases underwent re-evaluation at six months; the median threshold, discrimination and identification score was 37.1 (interquartile range, 4.75) with no significant differences compared with the controls | ||
| 520 | |a CONCLUSION: Six months after infection, the prevalence of olfactory dysfunction in patients did not differ significantly from the control population | ||
| 650 | 4 | |a Journal Article | |
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| 700 | 1 | |a Lechien, Jerome R |e verfasserin |4 aut | |
| 700 | 1 | |a Mayo-Yáñez, Miguel |e verfasserin |4 aut | |
| 700 | 1 | |a Petrocelli, Marzia |e verfasserin |4 aut | |
| 700 | 1 | |a Pistidda, Laura |e verfasserin |4 aut | |
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| 700 | 1 | |a Hopkins, Claire |e verfasserin |4 aut | |
| 700 | 1 | |a De Riu, Giacomo |e verfasserin |4 aut | |
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