Calcium dobesilate attenuates renal ischemia-reperfusion injury in a mouse model
Copyright© Bentham Science Publishers; For any queries, please email at epubbenthamscience.net..
BACKGROUND: Calcium dobesilate (CaD) is a microvascular protective agent that can significantly improve kidney function by reducing urinary protein, serum creatinine, and urea nitrogen levels. The effects of CaD on ischemia-reperfusion-induced acute kidney injury (AKI) were investigated in this study.
METHOD: In this study, The Balb/c mice were randomly divided into (1) sham group, (2) I/R group, (3) I/R group + CaD (50 mg/kg) and (4) I/R group + CaD (500 mg/kg). After treatment, serum creatinine and urea nitrogen were detected. The levels of superoxide dismutase (SOD) and malonaldehyde (MDA) were examined. Then, the effects of CaD H2O2-damaged HK-2 cells were investigated, as reflected by the results of cell viability, reactive oxygen species (ROS) level, apoptosis and markers of kidney injury.
RESULTS: The results showed that CaD treatment effectively attenuated the renal functions, pathological changes, and oxidative stress in I/R-induced AKI mice. It effectively reduced ROS production and improved MMP and apoptosis in H2O2-damaged HK-2 cells. The increased expression of apoptosis-related proteins and kidney injury biomarkers were significantly ameliorated after CaD treatment.
CONCLUSION: Overall, CaD effectively ameliorated renal injury by eliminating ROS and demonstrated in vivo and in vitro for I/R-induced AKI. CaD has been shown to be a promising therapeutic agent for the treatment of I/R-induced AKI.
Medienart: |
E-Artikel |
---|
Erscheinungsjahr: |
2023 |
---|---|
Erschienen: |
2023 |
Enthalten in: |
Zur Gesamtaufnahme - year:2023 |
---|---|
Enthalten in: |
Current molecular medicine - (2023) vom: 16. Mai |
Sprache: |
Englisch |
---|
Beteiligte Personen: |
Yang, Le-Le [VerfasserIn] |
---|
Links: |
---|
Themen: |
Acute kidney injury |
---|
Anmerkungen: |
Date Revised 17.05.2023 published: Print-Electronic Citation Status Publisher |
---|
doi: |
10.2174/1566524023666230516115052 |
---|
funding: |
|
---|---|
Förderinstitution / Projekttitel: |
|
PPN (Katalog-ID): |
NLM35696812X |
---|
LEADER | 01000naa a22002652 4500 | ||
---|---|---|---|
001 | NLM35696812X | ||
003 | DE-627 | ||
005 | 20231226071558.0 | ||
007 | cr uuu---uuuuu | ||
008 | 231226s2023 xx |||||o 00| ||eng c | ||
024 | 7 | |a 10.2174/1566524023666230516115052 |2 doi | |
028 | 5 | 2 | |a pubmed24n1189.xml |
035 | |a (DE-627)NLM35696812X | ||
035 | |a (NLM)37194224 | ||
040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
041 | |a eng | ||
100 | 1 | |a Yang, Le-Le |e verfasserin |4 aut | |
245 | 1 | 0 | |a Calcium dobesilate attenuates renal ischemia-reperfusion injury in a mouse model |
264 | 1 | |c 2023 | |
336 | |a Text |b txt |2 rdacontent | ||
337 | |a ƒaComputermedien |b c |2 rdamedia | ||
338 | |a ƒa Online-Ressource |b cr |2 rdacarrier | ||
500 | |a Date Revised 17.05.2023 | ||
500 | |a published: Print-Electronic | ||
500 | |a Citation Status Publisher | ||
520 | |a Copyright© Bentham Science Publishers; For any queries, please email at epubbenthamscience.net. | ||
520 | |a BACKGROUND: Calcium dobesilate (CaD) is a microvascular protective agent that can significantly improve kidney function by reducing urinary protein, serum creatinine, and urea nitrogen levels. The effects of CaD on ischemia-reperfusion-induced acute kidney injury (AKI) were investigated in this study | ||
520 | |a METHOD: In this study, The Balb/c mice were randomly divided into (1) sham group, (2) I/R group, (3) I/R group + CaD (50 mg/kg) and (4) I/R group + CaD (500 mg/kg). After treatment, serum creatinine and urea nitrogen were detected. The levels of superoxide dismutase (SOD) and malonaldehyde (MDA) were examined. Then, the effects of CaD H2O2-damaged HK-2 cells were investigated, as reflected by the results of cell viability, reactive oxygen species (ROS) level, apoptosis and markers of kidney injury | ||
520 | |a RESULTS: The results showed that CaD treatment effectively attenuated the renal functions, pathological changes, and oxidative stress in I/R-induced AKI mice. It effectively reduced ROS production and improved MMP and apoptosis in H2O2-damaged HK-2 cells. The increased expression of apoptosis-related proteins and kidney injury biomarkers were significantly ameliorated after CaD treatment | ||
520 | |a CONCLUSION: Overall, CaD effectively ameliorated renal injury by eliminating ROS and demonstrated in vivo and in vitro for I/R-induced AKI. CaD has been shown to be a promising therapeutic agent for the treatment of I/R-induced AKI | ||
650 | 4 | |a Journal Article | |
650 | 4 | |a acute kidney injury | |
650 | 4 | |a apoptosis | |
650 | 4 | |a calcium dobesilate | |
650 | 4 | |a ischemia reperfusion | |
650 | 4 | |a oxidative stress | |
700 | 1 | |a Cao, Xiao-Jing |e verfasserin |4 aut | |
773 | 0 | 8 | |i Enthalten in |t Current molecular medicine |d 2001 |g (2023) vom: 16. Mai |w (DE-627)NLM117823937 |x 1875-5666 |7 nnns |
773 | 1 | 8 | |g year:2023 |g day:16 |g month:05 |
856 | 4 | 0 | |u http://dx.doi.org/10.2174/1566524023666230516115052 |3 Volltext |
912 | |a GBV_USEFLAG_A | ||
912 | |a GBV_NLM | ||
951 | |a AR | ||
952 | |j 2023 |b 16 |c 05 |