Protein-rich yeast extract (®fermgard) has potential antioxidant and anti-aging activities
Copyright © 2023 Elsevier Inc. All rights reserved..
There existed a deficiency in the research on the nutritional activities of microbial (yeast) active substances in antioxidant and anti-aging activities, although the research objects were concentrated in animals and plants in recent years. In this study, the anti-oxidant and anti-aging activities of protein-rich yeast extract (®fermgard) (YE) were investigated through Caenorhabditis elegans (C. elegans). The results indicated that YE could improve the lifespan and anti-stress ability by up-regulating the activities of antioxidant enzymes in C. elegans. Meanwhile, the mRNA transcriptional level of daf-16, skn-1 and sod-3 was significantly up-regulated. In addition, the composition and level of the gut microbiota and metabolite were modulated. YE exerts antioxidant and anti-aging activities by regulating the expression of anti-oxidation-related mRNA, gut microbiota and metabolites in C. elegans, providing a basis for exploring the deep mechanism of YE improving health. At the same time, it provides new ideas for the development of functional foods.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2023 |
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| Erschienen: |
2023 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:270 |
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| Enthalten in: |
Comparative biochemistry and physiology. Toxicology & pharmacology : CBP - 270(2023) vom: 10. Aug., Seite 109656 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Li, Quancen [VerfasserIn] |
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| Links: |
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| Anmerkungen: |
Date Completed 02.06.2023 Date Revised 02.06.2023 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1016/j.cbpc.2023.109656 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| 520 | |a Copyright © 2023 Elsevier Inc. All rights reserved. | ||
| 520 | |a There existed a deficiency in the research on the nutritional activities of microbial (yeast) active substances in antioxidant and anti-aging activities, although the research objects were concentrated in animals and plants in recent years. In this study, the anti-oxidant and anti-aging activities of protein-rich yeast extract (®fermgard) (YE) were investigated through Caenorhabditis elegans (C. elegans). The results indicated that YE could improve the lifespan and anti-stress ability by up-regulating the activities of antioxidant enzymes in C. elegans. Meanwhile, the mRNA transcriptional level of daf-16, skn-1 and sod-3 was significantly up-regulated. In addition, the composition and level of the gut microbiota and metabolite were modulated. YE exerts antioxidant and anti-aging activities by regulating the expression of anti-oxidation-related mRNA, gut microbiota and metabolites in C. elegans, providing a basis for exploring the deep mechanism of YE improving health. At the same time, it provides new ideas for the development of functional foods | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Anti-oxidative and anti-aging effects | |
| 650 | 4 | |a Caenorhabditis elegans | |
| 650 | 4 | |a Gut microbiota | |
| 650 | 4 | |a Metabolites | |
| 650 | 4 | |a Protein-rich yeast extract | |
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| 700 | 1 | |a Li, Na |e verfasserin |4 aut | |
| 700 | 1 | |a Su, Weibin |e verfasserin |4 aut | |
| 700 | 1 | |a Li, Haicheng |e verfasserin |4 aut | |
| 700 | 1 | |a Zhang, Haibo |e verfasserin |4 aut | |
| 700 | 1 | |a Chen, Zhixian |e verfasserin |4 aut | |
| 700 | 1 | |a Gong, Shiyu |e verfasserin |4 aut | |
| 700 | 1 | |a Ge, Xiaodong |e verfasserin |4 aut | |
| 700 | 1 | |a Liu, Bin |e verfasserin |4 aut | |
| 700 | 1 | |a Zeng, Feng |e verfasserin |4 aut | |
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