Effect and mechanism of Magnolia officinalis pharmacopuncture for treating localized fat via network pharmacology and experimental study
© 2023 Korea Institute of Oriental Medicine. Published by Elsevier B.V..
Background: Recently, for various reasons, the need for non-invasive treatment for localized fat has emerged. This study confirmed whether Magnolia officinalis (MO) pharmacopuncture reduces localized fat by promoting lipolysis and inhibiting adipogenesis.
Methods: The network was built using genes related to the active compound of MO and the mode of action of MO was predicted by the functional enrichment analysis. Based on the result from network analysis, 100 µL of 2 mg/mL MO pharmacopuncture was injected into the inguinal fat pad for 6 weeks in obese C57BL/6J mice. Normal saline was injected into the right-side inguinal fat pad as a self-control.
Results: It was expected that the 'AMP-activated protein kinase (AMPK) signaling pathway' would be affected by the MO Network. MO pharmacopuncture reduced the weight and size of inguinal fat in HFD-induced obese mice. The phosphorylation of AMPK along with the increases of lipases was significantly increased by MO injection. Also, the expression levels of fatty acid synthesize-related mediators were suppressed by MO injection.
Conclusion: Our results demonstrated that MO pharmacopuncture promoted the expression of AMPK, which has beneficial effects on activation of lipolysis and inhibition of lipogenesis. Pharmacopuncture of MO can be a non-surgical alternative therapy in the treatment of local fat tissue.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2023 |
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| Erschienen: |
2023 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:12 |
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| Enthalten in: |
Integrative medicine research - 12(2023), 2 vom: 28. Juni, Seite 100948 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Choi, Won Jun [VerfasserIn] |
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| Links: |
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| Themen: |
AMPK signaling pathway |
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| Anmerkungen: |
Date Revised 16.05.2023 published: Print-Electronic Citation Status PubMed-not-MEDLINE |
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| doi: |
10.1016/j.imr.2023.100948 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM356841812 |
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| 100 | 1 | |a Choi, Won Jun |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Effect and mechanism of Magnolia officinalis pharmacopuncture for treating localized fat via network pharmacology and experimental study |
| 264 | 1 | |c 2023 | |
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| 500 | |a Date Revised 16.05.2023 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status PubMed-not-MEDLINE | ||
| 520 | |a © 2023 Korea Institute of Oriental Medicine. Published by Elsevier B.V. | ||
| 520 | |a Background: Recently, for various reasons, the need for non-invasive treatment for localized fat has emerged. This study confirmed whether Magnolia officinalis (MO) pharmacopuncture reduces localized fat by promoting lipolysis and inhibiting adipogenesis | ||
| 520 | |a Methods: The network was built using genes related to the active compound of MO and the mode of action of MO was predicted by the functional enrichment analysis. Based on the result from network analysis, 100 µL of 2 mg/mL MO pharmacopuncture was injected into the inguinal fat pad for 6 weeks in obese C57BL/6J mice. Normal saline was injected into the right-side inguinal fat pad as a self-control | ||
| 520 | |a Results: It was expected that the 'AMP-activated protein kinase (AMPK) signaling pathway' would be affected by the MO Network. MO pharmacopuncture reduced the weight and size of inguinal fat in HFD-induced obese mice. The phosphorylation of AMPK along with the increases of lipases was significantly increased by MO injection. Also, the expression levels of fatty acid synthesize-related mediators were suppressed by MO injection | ||
| 520 | |a Conclusion: Our results demonstrated that MO pharmacopuncture promoted the expression of AMPK, which has beneficial effects on activation of lipolysis and inhibition of lipogenesis. Pharmacopuncture of MO can be a non-surgical alternative therapy in the treatment of local fat tissue | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a AMPK signaling pathway | |
| 650 | 4 | |a Localized fat | |
| 650 | 4 | |a Magnolia officinalis | |
| 650 | 4 | |a Network pharmacology | |
| 650 | 4 | |a Pharmacopuncture | |
| 700 | 1 | |a Kim, Mi Hye |e verfasserin |4 aut | |
| 700 | 1 | |a Park, Nayoung |e verfasserin |4 aut | |
| 700 | 1 | |a Chung, Jae Yoon |e verfasserin |4 aut | |
| 700 | 1 | |a Park, Sang Jun |e verfasserin |4 aut | |
| 700 | 1 | |a Yang, Woong Mo |e verfasserin |4 aut | |
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