Biomarkers of collagen turnover and wound healing in chronic thromboembolic pulmonary hypertension patients before and after pulmonary endarterectomy
Copyright © 2023 The Author(s). Published by Elsevier B.V. All rights reserved..
BACKGROUND: In chronic thromboembolic pulmonary hypertension (CTEPH), fibrotic remodeling of tissue and thrombi contributes to disease progression. Removal of the thromboembolic mass by pulmonary endarterectomy (PEA) improves hemodynamics and right ventricular function, but the roles of different collagens before as well as after PEA are not well understood.
METHODS: In this study, hemodynamics and 15 different biomarkers of collagen turnover and wound healing were evaluated in 40 CTEPH patients at diagnosis (baseline) and 6 and 18 months after PEA. Baseline biomarker levels were compared with a historical cohort of 40 healthy subjects.
RESULTS: Biomarkers of collagen turnover and wound healing were increased in CTEPH patients compared with healthy controls, including a 35-fold increase in the PRO-C4 marker of type IV collagen formation and a 55-fold increase in the C3M marker of type III collagen degradation. PEA reduced pulmonary pressures to almost normal levels 6 months after the procedure, with no further improvement at 18 months. There were no changes in any of the measured biomarkers after PEA.
CONCLUSIONS: Biomarkers of collagen formation and degradation are increased in CTEPH suggesting a high collagen turnover. While PEA effectively reduces pulmonary pressures, collagen turnover is not significantly modified by surgical PEA.
| Errataetall: |
CommentIn: Int J Cardiol. 2023 Dec 1;392:131304. - PMID 37652276 |
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| Medienart: |
E-Artikel |
| Erscheinungsjahr: |
2023 |
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| Erschienen: |
2023 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:384 |
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| Enthalten in: |
International journal of cardiology - 384(2023) vom: 01. Aug., Seite 82-88 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Andersen, Stine [VerfasserIn] |
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| Links: |
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| Themen: |
9007-34-5 |
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| Anmerkungen: |
Date Completed 09.06.2023 Date Revised 09.11.2023 published: Print-Electronic CommentIn: Int J Cardiol. 2023 Dec 1;392:131304. - PMID 37652276 Citation Status MEDLINE |
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| doi: |
10.1016/j.ijcard.2023.05.016 |
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| PPN (Katalog-ID): |
NLM356815692 |
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| 500 | |a CommentIn: Int J Cardiol. 2023 Dec 1;392:131304. - PMID 37652276 | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a Copyright © 2023 The Author(s). Published by Elsevier B.V. All rights reserved. | ||
| 520 | |a BACKGROUND: In chronic thromboembolic pulmonary hypertension (CTEPH), fibrotic remodeling of tissue and thrombi contributes to disease progression. Removal of the thromboembolic mass by pulmonary endarterectomy (PEA) improves hemodynamics and right ventricular function, but the roles of different collagens before as well as after PEA are not well understood | ||
| 520 | |a METHODS: In this study, hemodynamics and 15 different biomarkers of collagen turnover and wound healing were evaluated in 40 CTEPH patients at diagnosis (baseline) and 6 and 18 months after PEA. Baseline biomarker levels were compared with a historical cohort of 40 healthy subjects | ||
| 520 | |a RESULTS: Biomarkers of collagen turnover and wound healing were increased in CTEPH patients compared with healthy controls, including a 35-fold increase in the PRO-C4 marker of type IV collagen formation and a 55-fold increase in the C3M marker of type III collagen degradation. PEA reduced pulmonary pressures to almost normal levels 6 months after the procedure, with no further improvement at 18 months. There were no changes in any of the measured biomarkers after PEA | ||
| 520 | |a CONCLUSIONS: Biomarkers of collagen formation and degradation are increased in CTEPH suggesting a high collagen turnover. While PEA effectively reduces pulmonary pressures, collagen turnover is not significantly modified by surgical PEA | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Biomarkers | |
| 650 | 4 | |a Chronic thromboembolic pulmonary hypertension | |
| 650 | 4 | |a Collagen | |
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| 700 | 1 | |a Reese-Petersen, Alexander Lynge |e verfasserin |4 aut | |
| 700 | 1 | |a Braams, Natalia |e verfasserin |4 aut | |
| 700 | 1 | |a Andersen, Mads Jønsson |e verfasserin |4 aut | |
| 700 | 1 | |a Mellemkjær, Søren |e verfasserin |4 aut | |
| 700 | 1 | |a Andersen, Asger |e verfasserin |4 aut | |
| 700 | 1 | |a Bogaard, Harm Jan |e verfasserin |4 aut | |
| 700 | 1 | |a Genovese, Federica |e verfasserin |4 aut | |
| 700 | 1 | |a Nielsen-Kudsk, Jens Erik |e verfasserin |4 aut | |
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