Two new pregnane glycosides from the root of Cynanchum auriculatum
Two new pregnane glycosides (1 and 2), together with four known ones (3- 6), were isolated from the roots of Cynanchum auriculatum Royle ex Wight (Asclepiadaceae). On the basis of detailed spectroscopic analysis and chemical method, the structures of new compounds were characterized to be metaplexigenin 3-O-β-D-cymaropyranosyl- (1→4)-α-L-diginopyranosyl-(1→4)-β-D-cymaropyranoside (1), metaplexigenin 3-O-α-L-diginopyranosyl-(1→4)-β-D-cymaropyranoside (2). All the isolated compounds (1-6) were tested for their in vitro inhibitory activity against the growth of human colon cancer cell lines HCT-116. Compounds 5 and 6 showed significant cytoxicities with IC50 values of 43.58 µM and 52.21 µM.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2023 |
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| Erschienen: |
2023 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:25 |
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| Enthalten in: |
Journal of Asian natural products research - 25(2023), 12 vom: 11. Dez., Seite 1184-1190 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Hu, Bo [VerfasserIn] |
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| Links: |
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| Themen: |
Asclepiadaceae |
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| Anmerkungen: |
Date Completed 19.12.2023 Date Revised 19.12.2023 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1080/10286020.2023.2211550 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM356809005 |
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| 520 | |a Two new pregnane glycosides (1 and 2), together with four known ones (3- 6), were isolated from the roots of Cynanchum auriculatum Royle ex Wight (Asclepiadaceae). On the basis of detailed spectroscopic analysis and chemical method, the structures of new compounds were characterized to be metaplexigenin 3-O-β-D-cymaropyranosyl- (1→4)-α-L-diginopyranosyl-(1→4)-β-D-cymaropyranoside (1), metaplexigenin 3-O-α-L-diginopyranosyl-(1→4)-β-D-cymaropyranoside (2). All the isolated compounds (1-6) were tested for their in vitro inhibitory activity against the growth of human colon cancer cell lines HCT-116. Compounds 5 and 6 showed significant cytoxicities with IC50 values of 43.58 µM and 52.21 µM | ||
| 650 | 4 | |a Journal Article | |
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| 650 | 4 | |a cytotoxic activity | |
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| 650 | 7 | |a Glycosides |2 NLM | |
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| 700 | 1 | |a Liu, Ting |e verfasserin |4 aut | |
| 700 | 1 | |a Liu, Yin |e verfasserin |4 aut | |
| 700 | 1 | |a Xu, Tian-Qi |e verfasserin |4 aut | |
| 700 | 1 | |a Shu, Qing |e verfasserin |4 aut | |
| 700 | 1 | |a Zhou, Guang-Xiong |e verfasserin |4 aut | |
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