Subclinical markers of liver damage in patients with arterial hypertension and obesity
AIM: To investigate the possibility of preclinical detection of liver damage in patients with hypertension and obesity.
MATERIALS AND METHODS: The study included 168 patients with hypertension aged 30 to 60 years. All patients underwent general clinical and laboratory-instrumental examination, including ultrasound of the abdominal organs with Doppler assessment of blood flow and determination of markers such as ALT, AST, TG, lipid profile indicators at inclusion, after a month, three months and nine months.
RESULTS: Depending on the presence of obesity, all patients with hypertension were divided into two groups. Obese patients had a statistically significant increase in office blood pressure, FSI, the ratio of TG and LDL-C to HDL-C, a more significant higher average levels of glucose, TG and ALT levels, as well as impaired hepatic blood flow according to ultrasound.
CONCLUSION: Indicators of FSI, ALT/AST ratio, ratio of TG and LDL-С to HDL-C as well as assessment of hepatic blood flow indicators can be used for early diagnosis of nonalcoholic fatty liver disease, as they predict liver steatosis.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2023 |
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| Erschienen: |
2023 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:94 |
|---|---|
| Enthalten in: |
Terapevticheskii arkhiv - 94(2023), 12 vom: 16. Jan., Seite 1367-1373 |
| Sprache: |
Russisch |
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| Beteiligte Personen: |
Sadulaeva, I A [VerfasserIn] |
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| Links: |
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| Themen: |
Arterial hypertension |
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| Anmerkungen: |
Date Completed 15.05.2023 Date Revised 15.05.2023 published: Electronic Citation Status MEDLINE |
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| doi: |
10.26442/00403660.2022.12.201993 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM356700666 |
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| 500 | |a Date Completed 15.05.2023 | ||
| 500 | |a Date Revised 15.05.2023 | ||
| 500 | |a published: Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a AIM: To investigate the possibility of preclinical detection of liver damage in patients with hypertension and obesity | ||
| 520 | |a MATERIALS AND METHODS: The study included 168 patients with hypertension aged 30 to 60 years. All patients underwent general clinical and laboratory-instrumental examination, including ultrasound of the abdominal organs with Doppler assessment of blood flow and determination of markers such as ALT, AST, TG, lipid profile indicators at inclusion, after a month, three months and nine months | ||
| 520 | |a RESULTS: Depending on the presence of obesity, all patients with hypertension were divided into two groups. Obese patients had a statistically significant increase in office blood pressure, FSI, the ratio of TG and LDL-C to HDL-C, a more significant higher average levels of glucose, TG and ALT levels, as well as impaired hepatic blood flow according to ultrasound | ||
| 520 | |a CONCLUSION: Indicators of FSI, ALT/AST ratio, ratio of TG and LDL-С to HDL-C as well as assessment of hepatic blood flow indicators can be used for early diagnosis of nonalcoholic fatty liver disease, as they predict liver steatosis | ||
| 650 | 4 | |a English Abstract | |
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Framingham steatosis index | |
| 650 | 4 | |a arterial hypertension | |
| 650 | 4 | |a diabetes mellitus | |
| 650 | 4 | |a liver steatosis | |
| 650 | 4 | |a nonalcoholic fatty liver disease | |
| 650 | 4 | |a obesity | |
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| 700 | 1 | |a Yushchuk, E N |e verfasserin |4 aut | |
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| 700 | 1 | |a Trofimenko, O S |e verfasserin |4 aut | |
| 700 | 1 | |a Medvedeva, E G |e verfasserin |4 aut | |
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