Euterpe oleracea Mart. (Açai) seed extract improves physical performance in old rats by restoring vascular function and oxidative status and activating mitochondrial muscle biogenesis
© The Author(s) 2023. Published by Oxford University Press on behalf of the Royal Pharmaceutical Society. All rights reserved. For permissions, please e-mail: journals.permissionsoup.com..
OBJECTIVES: Alterations in cardiovascular and skeletal muscle function are hallmarks of ageing that lead to exercise intolerance. We aimed to examine whether the treatment with Euterpe oleracea Mart. seed extract (ASE) associated with exercise training improves aerobic exercise performance by promoting healthy ageing in the elderly.
METHODS: Male Wistar rats were divided into five groups: Young (3 months), Old (18 months), Old+ASE (ASE 200 mg/kg/day), Old+Training (exercise training 30 min/day; 5 days/week) and Old+Training+ASE, for 4 weeks.
KEY FINDINGS: ASE treatment increased the exercise time and the running distance concerning the initial maximal treadmill stress test (MTST) in the Old+Training+ASE group. Exercise training or ASE treatment restored the aorta oxidative damage and antioxidant defence. It reduced the acetylcholine (ACh)-induced vasodilation in the aorta of old animals to the same values as the young and improved hypertension. Only the association of both strategies restored the ACh-induced vasodilation in mesentery arteries. Remarkably, exercise training associated with ASE increased the antioxidant defence, nitrite levels and expression of the mitochondrial SIRT-1, PGC1α in soleus muscle homogenates.
CONCLUSIONS: ASE treatment associated with exercise training contributes to better exercise performance and tolerance in ageing by improving vascular function, oxidative stress and activating the muscle SIRT-1/PGC-1α pathway.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2023 |
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| Erschienen: |
2023 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:75 |
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| Enthalten in: |
The Journal of pharmacy and pharmacology - 75(2023), 7 vom: 05. Juli, Seite 969-984 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
de Andrade Soares, Ricardo [VerfasserIn] |
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| Links: |
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| Themen: |
Ageing |
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| Anmerkungen: |
Date Completed 07.07.2023 Date Revised 18.07.2023 published: Print Citation Status MEDLINE |
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| doi: |
10.1093/jpp/rgad040 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM356666808 |
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| 100 | 1 | |a de Andrade Soares, Ricardo |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Euterpe oleracea Mart. (Açai) seed extract improves physical performance in old rats by restoring vascular function and oxidative status and activating mitochondrial muscle biogenesis |
| 264 | 1 | |c 2023 | |
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| 500 | |a Date Revised 18.07.2023 | ||
| 500 | |a published: Print | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a © The Author(s) 2023. Published by Oxford University Press on behalf of the Royal Pharmaceutical Society. All rights reserved. For permissions, please e-mail: journals.permissionsoup.com. | ||
| 520 | |a OBJECTIVES: Alterations in cardiovascular and skeletal muscle function are hallmarks of ageing that lead to exercise intolerance. We aimed to examine whether the treatment with Euterpe oleracea Mart. seed extract (ASE) associated with exercise training improves aerobic exercise performance by promoting healthy ageing in the elderly | ||
| 520 | |a METHODS: Male Wistar rats were divided into five groups: Young (3 months), Old (18 months), Old+ASE (ASE 200 mg/kg/day), Old+Training (exercise training 30 min/day; 5 days/week) and Old+Training+ASE, for 4 weeks | ||
| 520 | |a KEY FINDINGS: ASE treatment increased the exercise time and the running distance concerning the initial maximal treadmill stress test (MTST) in the Old+Training+ASE group. Exercise training or ASE treatment restored the aorta oxidative damage and antioxidant defence. It reduced the acetylcholine (ACh)-induced vasodilation in the aorta of old animals to the same values as the young and improved hypertension. Only the association of both strategies restored the ACh-induced vasodilation in mesentery arteries. Remarkably, exercise training associated with ASE increased the antioxidant defence, nitrite levels and expression of the mitochondrial SIRT-1, PGC1α in soleus muscle homogenates | ||
| 520 | |a CONCLUSIONS: ASE treatment associated with exercise training contributes to better exercise performance and tolerance in ageing by improving vascular function, oxidative stress and activating the muscle SIRT-1/PGC-1α pathway | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Euterpe oleracea Mart | |
| 650 | 4 | |a ageing | |
| 650 | 4 | |a antioxidant | |
| 650 | 4 | |a exercise | |
| 650 | 4 | |a mitochondrial biogenesis | |
| 650 | 4 | |a vascular dysfunction | |
| 650 | 7 | |a Antioxidants |2 NLM | |
| 650 | 7 | |a Plant Extracts |2 NLM | |
| 700 | 1 | |a Cardoso de Oliveira, Beatriz |e verfasserin |4 aut | |
| 700 | 1 | |a Dos Santos Ferreira, Flávia |e verfasserin |4 aut | |
| 700 | 1 | |a Pontes de Menezes, Matheus |e verfasserin |4 aut | |
| 700 | 1 | |a Henrique Romão, Matheus |e verfasserin |4 aut | |
| 700 | 1 | |a Freitas de Bem, Graziele |e verfasserin |4 aut | |
| 700 | 1 | |a Nascimento, Ana Lúcia Rosa |e verfasserin |4 aut | |
| 700 | 1 | |a José de Carvalho, Jorge |e verfasserin |4 aut | |
| 700 | 1 | |a Aguiar da Costa, Cristiane |e verfasserin |4 aut | |
| 700 | 1 | |a Teixeira Ognibene, Dayane |e verfasserin |4 aut | |
| 700 | 1 | |a Soares de Moura, Roberto |e verfasserin |4 aut | |
| 700 | 1 | |a Castro Resende, Angela |e verfasserin |4 aut | |
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