Ratio between right ventricular longitudinal strain and pulmonary arterial systolic pressure : A novel prognostic parameter in patients with severe tricuspid regurgitation
Copyright © 2023 Elsevier B.V. All rights reserved..
BACKGROUND: In terms of pathophysiology, tricuspid regurgitation (TR), right ventricular function and pulmonary artery pressure are linked to each other. Our aim was to analyze whether the echocardiography-derived right ventricular free wall longitudinal strain/pulmonary artery systolic pressures (RVFWLS/PASP) ratio can improve risk stratification in patients with severe tricuspid regurgitation (TR).
METHODS: In this single-center retrospective study, 250 consecutive patients with severe TR were enrolled from December 2015 to December 2018. Baseline clinical and echocardiographic parameters were collected. Echocardiography-derived TAPSE/PASP and RVFWLS/PASP were evaluated. The primary endpoint was all-cause mortality.
RESULTS: Out of 250 consecutive patients, 171 meet inclusion criteria. Patients were predominantly female, with several cardiovascular risk factors and comorbidities. RVFWLS/PASP ≤0.34%/mmHg (AUC 0.68, p < 0.001, sensitivity 70%, specificity 67%) was associated with baseline clinical RV heart failure (p = 0.03). After univariate and multivariate analyses, RVFWLS/PASP, but not TAPSE/PASP, independently correlated with all-cause mortality (HR 0.004, p = 0.02). Patients with RVFWLS/PASP >0.26%/mmHg (AUC 0.74, p < 0.001, sensitivity 77%, specificity 52%) showed higher survival rates (p = 0.02). In addition at 24 months follow-up, the Kaplan-Meyer curves showed patients with RVFWLS >14% & RVFWLS/PASP >0.26%/mmHg had the best survival rate compared to patients without.
CONCLUSION: RVFWLS/PASP is independently associated with baseline RV heart failure and poor long-term prognosis in patients with severe TR.
| Errataetall: |
CommentIn: Int J Cardiol. 2023 Oct 1;388:131114. - PMID 37315740 |
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| Medienart: |
E-Artikel |
| Erscheinungsjahr: |
2023 |
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| Erschienen: |
2023 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:384 |
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| Enthalten in: |
International journal of cardiology - 384(2023) vom: 01. Aug., Seite 55-61 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Ancona, Francesco [VerfasserIn] |
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| Links: |
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| Themen: |
Echocardiography-derived pulmonary artery systolic pressure |
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| Anmerkungen: |
Date Completed 09.06.2023 Date Revised 14.09.2023 published: Print-Electronic CommentIn: Int J Cardiol. 2023 Oct 1;388:131114. - PMID 37315740 Citation Status MEDLINE |
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| doi: |
10.1016/j.ijcard.2023.04.056 |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM356521672 |
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| 100 | 1 | |a Ancona, Francesco |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Ratio between right ventricular longitudinal strain and pulmonary arterial systolic pressure |b A novel prognostic parameter in patients with severe tricuspid regurgitation |
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| 500 | |a Date Completed 09.06.2023 | ||
| 500 | |a Date Revised 14.09.2023 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a CommentIn: Int J Cardiol. 2023 Oct 1;388:131114. - PMID 37315740 | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a Copyright © 2023 Elsevier B.V. All rights reserved. | ||
| 520 | |a BACKGROUND: In terms of pathophysiology, tricuspid regurgitation (TR), right ventricular function and pulmonary artery pressure are linked to each other. Our aim was to analyze whether the echocardiography-derived right ventricular free wall longitudinal strain/pulmonary artery systolic pressures (RVFWLS/PASP) ratio can improve risk stratification in patients with severe tricuspid regurgitation (TR) | ||
| 520 | |a METHODS: In this single-center retrospective study, 250 consecutive patients with severe TR were enrolled from December 2015 to December 2018. Baseline clinical and echocardiographic parameters were collected. Echocardiography-derived TAPSE/PASP and RVFWLS/PASP were evaluated. The primary endpoint was all-cause mortality | ||
| 520 | |a RESULTS: Out of 250 consecutive patients, 171 meet inclusion criteria. Patients were predominantly female, with several cardiovascular risk factors and comorbidities. RVFWLS/PASP ≤0.34%/mmHg (AUC 0.68, p < 0.001, sensitivity 70%, specificity 67%) was associated with baseline clinical RV heart failure (p = 0.03). After univariate and multivariate analyses, RVFWLS/PASP, but not TAPSE/PASP, independently correlated with all-cause mortality (HR 0.004, p = 0.02). Patients with RVFWLS/PASP >0.26%/mmHg (AUC 0.74, p < 0.001, sensitivity 77%, specificity 52%) showed higher survival rates (p = 0.02). In addition at 24 months follow-up, the Kaplan-Meyer curves showed patients with RVFWLS >14% & RVFWLS/PASP >0.26%/mmHg had the best survival rate compared to patients without | ||
| 520 | |a CONCLUSION: RVFWLS/PASP is independently associated with baseline RV heart failure and poor long-term prognosis in patients with severe TR | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Echocardiography-derived pulmonary artery systolic pressure | |
| 650 | 4 | |a Longitudinal strain | |
| 650 | 4 | |a Right ventricle | |
| 650 | 4 | |a Tricuspid regurgitation | |
| 700 | 1 | |a Margonato, Davide |e verfasserin |4 aut | |
| 700 | 1 | |a Menzà, Gregorio |e verfasserin |4 aut | |
| 700 | 1 | |a Bellettini, Matteo |e verfasserin |4 aut | |
| 700 | 1 | |a Melillo, Francesco |e verfasserin |4 aut | |
| 700 | 1 | |a Stella, Stefano |e verfasserin |4 aut | |
| 700 | 1 | |a Capogrosso, Cristina |e verfasserin |4 aut | |
| 700 | 1 | |a Ingallina, Giacomo |e verfasserin |4 aut | |
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| 700 | 1 | |a Boccellino, Antonio |e verfasserin |4 aut | |
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