A shift in the mechanisms controlling hippocampal engram formation during brain maturation
The ability to form precise, episodic memories develops with age, with young children only able to form gist-like memories that lack precision. The cellular and molecular events in the developing hippocampus that underlie the emergence of precise, episodic-like memory are unclear. In mice, the absence of a competitive neuronal engram allocation process in the immature hippocampus precluded the formation of sparse engrams and precise memories until the fourth postnatal week, when inhibitory circuits in the hippocampus mature. This age-dependent shift in precision of episodic-like memories involved the functional maturation of parvalbumin-expressing interneurons in subfield CA1 through assembly of extracellular perineuronal nets, which is necessary and sufficient for the onset of competitive neuronal allocation, sparse engram formation, and memory precision.
| Medienart: |
E-Artikel |
|---|
| Erscheinungsjahr: |
2023 |
|---|---|
| Erschienen: |
2023 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:380 |
|---|---|
| Enthalten in: |
Science (New York, N.Y.) - 380(2023), 6644 vom: 05. Mai, Seite 543-551 |
| Sprache: |
Englisch |
|---|
| Beteiligte Personen: |
Ramsaran, Adam I [VerfasserIn] |
|---|
| Links: |
|---|
| Themen: |
|---|
| Anmerkungen: |
Date Completed 08.05.2023 Date Revised 25.05.2023 published: Print-Electronic Citation Status MEDLINE |
|---|
| doi: |
10.1126/science.ade6530 |
|---|
| funding: |
|
|---|---|
| Förderinstitution / Projekttitel: |
|
| PPN (Katalog-ID): |
NLM356446387 |
|---|
| LEADER | 01000naa a22002652 4500 | ||
|---|---|---|---|
| 001 | NLM356446387 | ||
| 003 | DE-627 | ||
| 005 | 20231226070459.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 231226s2023 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1126/science.ade6530 |2 doi | |
| 028 | 5 | 2 | |a pubmed24n1188.xml |
| 035 | |a (DE-627)NLM356446387 | ||
| 035 | |a (NLM)37141366 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
| 041 | |a eng | ||
| 100 | 1 | |a Ramsaran, Adam I |e verfasserin |4 aut | |
| 245 | 1 | 2 | |a A shift in the mechanisms controlling hippocampal engram formation during brain maturation |
| 264 | 1 | |c 2023 | |
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a ƒaComputermedien |b c |2 rdamedia | ||
| 338 | |a ƒa Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Date Completed 08.05.2023 | ||
| 500 | |a Date Revised 25.05.2023 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a The ability to form precise, episodic memories develops with age, with young children only able to form gist-like memories that lack precision. The cellular and molecular events in the developing hippocampus that underlie the emergence of precise, episodic-like memory are unclear. In mice, the absence of a competitive neuronal engram allocation process in the immature hippocampus precluded the formation of sparse engrams and precise memories until the fourth postnatal week, when inhibitory circuits in the hippocampus mature. This age-dependent shift in precision of episodic-like memories involved the functional maturation of parvalbumin-expressing interneurons in subfield CA1 through assembly of extracellular perineuronal nets, which is necessary and sufficient for the onset of competitive neuronal allocation, sparse engram formation, and memory precision | ||
| 650 | 4 | |a Journal Article | |
| 700 | 1 | |a Wang, Ying |e verfasserin |4 aut | |
| 700 | 1 | |a Golbabaei, Ali |e verfasserin |4 aut | |
| 700 | 1 | |a Aleshin, Stepan |e verfasserin |4 aut | |
| 700 | 1 | |a de Snoo, Mitchell L |e verfasserin |4 aut | |
| 700 | 1 | |a Yeung, Bi-Ru Amy |e verfasserin |4 aut | |
| 700 | 1 | |a Rashid, Asim J |e verfasserin |4 aut | |
| 700 | 1 | |a Awasthi, Ankit |e verfasserin |4 aut | |
| 700 | 1 | |a Lau, Jocelyn |e verfasserin |4 aut | |
| 700 | 1 | |a Tran, Lina M |e verfasserin |4 aut | |
| 700 | 1 | |a Ko, Sangyoon Y |e verfasserin |4 aut | |
| 700 | 1 | |a Abegg, Andrin |e verfasserin |4 aut | |
| 700 | 1 | |a Duan, Lana Chunan |e verfasserin |4 aut | |
| 700 | 1 | |a McKenzie, Cory |e verfasserin |4 aut | |
| 700 | 1 | |a Gallucci, Julia |e verfasserin |4 aut | |
| 700 | 1 | |a Ahmed, Moriam |e verfasserin |4 aut | |
| 700 | 1 | |a Kaushik, Rahul |e verfasserin |4 aut | |
| 700 | 1 | |a Dityatev, Alexander |e verfasserin |4 aut | |
| 700 | 1 | |a Josselyn, Sheena A |e verfasserin |4 aut | |
| 700 | 1 | |a Frankland, Paul W |e verfasserin |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Science (New York, N.Y.) |d 1880 |g 380(2023), 6644 vom: 05. Mai, Seite 543-551 |w (DE-627)NLM000023450 |x 1095-9203 |7 nnns |
| 773 | 1 | 8 | |g volume:380 |g year:2023 |g number:6644 |g day:05 |g month:05 |g pages:543-551 |
| 856 | 4 | 0 | |u http://dx.doi.org/10.1126/science.ade6530 |3 Volltext |
| 912 | |a GBV_USEFLAG_A | ||
| 912 | |a GBV_NLM | ||
| 951 | |a AR | ||
| 952 | |d 380 |j 2023 |e 6644 |b 05 |c 05 |h 543-551 | ||