Long-Term Quality of Life in Congenital Heart Disease Surgical Survivors : Multicenter Retrospective Study of Surgical and ICU Explanatory Factors
Copyright © 2023 by the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies..
OBJECTIVES: Greater congenital heart disease (CHD) complexity is associated with lower health-related quality of life (HRQOL). There are no data on the association between surgical and ICU factors and HRQOL in CHD survivors. This study assess the association between surgical and ICU factors and HRQOL in child and adolescent CHD survivors.
DESIGN: This was a corollary study of the Pediatric Cardiac Quality of Life Inventory (PCQLI) Testing Study.
SETTING: Eight pediatric hospitals participating in the PCQLI Study.
PATIENTS: Patients in the study had the Fontan procedure, surgery for tetralogy of Fallot (TOF), and transposition of the great arteries (TGAs).
MEASUREMENTS AND MAIN RESULTS: Surgical/ICU explanatory variables were collected by reviewing the medical records. Primary outcome variables (PCQLI Total patient and parent scores) and covariates were obtained from the Data Registry. General linear modeling was used to create the multivariable models. There were 572 patients included: mean ± sd of age 11.7 ± 2.9 years; CHD Fontan 45%, TOF/TGA 55%; number of cardiac surgeries 2 (1-9); and number of ICU admissions 3 (1-9). In multivariable models, lowest body temperature on cardiopulmonary bypass (CPB) was negatively associated with patient total score (p < 0.05). The total number of CPB runs was negatively associated with parent-reported PCQLI Total score (p < 0.02). Cumulative days on an inotropic/vasoactive drug in the ICU was negatively associated with all patient-/parent-reported PCQLI scores (p < 0.04). Neurological deficit at discharge was negatively associated with parent-reported PCQLI total score (p < 0.02). The variance explained by these factors ranged from 24% to 29%.
CONCLUSIONS: Surgical/ICU factors, demographic, and medical care utilization variables explain a low-to-moderate amount of variation in HRQOL. Research is needed to determine whether modification of these surgical and ICU factors improves HRQOL, and to identify other factors that contribute to unexplained variability.
| Medienart: |
E-Artikel |
|---|
| Erscheinungsjahr: |
2023 |
|---|---|
| Erschienen: |
2023 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:24 |
|---|---|
| Enthalten in: |
Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies - 24(2023), 5 vom: 01. Mai, Seite 391-398 |
| Sprache: |
Englisch |
|---|
| Beteiligte Personen: |
Marino, Bradley S [VerfasserIn] |
|---|
| Links: |
|---|
| Themen: |
Journal Article |
|---|
| Anmerkungen: |
Date Completed 08.05.2023 Date Revised 15.05.2023 published: Print-Electronic Citation Status MEDLINE |
|---|
| doi: |
10.1097/PCC.0000000000003190 |
|---|
| funding: |
|
|---|---|
| Förderinstitution / Projekttitel: |
|
| PPN (Katalog-ID): |
NLM356436101 |
|---|
| LEADER | 01000naa a22002652 4500 | ||
|---|---|---|---|
| 001 | NLM356436101 | ||
| 003 | DE-627 | ||
| 005 | 20231226070446.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 231226s2023 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1097/PCC.0000000000003190 |2 doi | |
| 028 | 5 | 2 | |a pubmed24n1188.xml |
| 035 | |a (DE-627)NLM356436101 | ||
| 035 | |a (NLM)37140331 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
| 041 | |a eng | ||
| 100 | 1 | |a Marino, Bradley S |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Long-Term Quality of Life in Congenital Heart Disease Surgical Survivors |b Multicenter Retrospective Study of Surgical and ICU Explanatory Factors |
| 264 | 1 | |c 2023 | |
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a ƒaComputermedien |b c |2 rdamedia | ||
| 338 | |a ƒa Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Date Completed 08.05.2023 | ||
| 500 | |a Date Revised 15.05.2023 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a Copyright © 2023 by the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies. | ||
| 520 | |a OBJECTIVES: Greater congenital heart disease (CHD) complexity is associated with lower health-related quality of life (HRQOL). There are no data on the association between surgical and ICU factors and HRQOL in CHD survivors. This study assess the association between surgical and ICU factors and HRQOL in child and adolescent CHD survivors | ||
| 520 | |a DESIGN: This was a corollary study of the Pediatric Cardiac Quality of Life Inventory (PCQLI) Testing Study | ||
| 520 | |a SETTING: Eight pediatric hospitals participating in the PCQLI Study | ||
| 520 | |a PATIENTS: Patients in the study had the Fontan procedure, surgery for tetralogy of Fallot (TOF), and transposition of the great arteries (TGAs) | ||
| 520 | |a MEASUREMENTS AND MAIN RESULTS: Surgical/ICU explanatory variables were collected by reviewing the medical records. Primary outcome variables (PCQLI Total patient and parent scores) and covariates were obtained from the Data Registry. General linear modeling was used to create the multivariable models. There were 572 patients included: mean ± sd of age 11.7 ± 2.9 years; CHD Fontan 45%, TOF/TGA 55%; number of cardiac surgeries 2 (1-9); and number of ICU admissions 3 (1-9). In multivariable models, lowest body temperature on cardiopulmonary bypass (CPB) was negatively associated with patient total score (p < 0.05). The total number of CPB runs was negatively associated with parent-reported PCQLI Total score (p < 0.02). Cumulative days on an inotropic/vasoactive drug in the ICU was negatively associated with all patient-/parent-reported PCQLI scores (p < 0.04). Neurological deficit at discharge was negatively associated with parent-reported PCQLI total score (p < 0.02). The variance explained by these factors ranged from 24% to 29% | ||
| 520 | |a CONCLUSIONS: Surgical/ICU factors, demographic, and medical care utilization variables explain a low-to-moderate amount of variation in HRQOL. Research is needed to determine whether modification of these surgical and ICU factors improves HRQOL, and to identify other factors that contribute to unexplained variability | ||
| 650 | 4 | |a Multicenter Study | |
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Research Support, N.I.H., Extramural | |
| 650 | 4 | |a Research Support, Non-U.S. Gov't | |
| 700 | 1 | |a Cassedy, Amy |e verfasserin |4 aut | |
| 700 | 1 | |a Brown, Katherine L |e verfasserin |4 aut | |
| 700 | 1 | |a Franklin, Rodney |e verfasserin |4 aut | |
| 700 | 1 | |a Gaynor, J William |e verfasserin |4 aut | |
| 700 | 1 | |a Cvetkovic, Mirjana |e verfasserin |4 aut | |
| 700 | 1 | |a Laker, Simon |e verfasserin |4 aut | |
| 700 | 1 | |a Levinson, Katherine |e verfasserin |4 aut | |
| 700 | 1 | |a MacGloin, Helen |e verfasserin |4 aut | |
| 700 | 1 | |a Mahony, Lynn |e verfasserin |4 aut | |
| 700 | 1 | |a McQuillan, Annette |e verfasserin |4 aut | |
| 700 | 1 | |a Mussatto, Kathleen |e verfasserin |4 aut | |
| 700 | 1 | |a O'Shea, Deirdre |e verfasserin |4 aut | |
| 700 | 1 | |a Newburger, Jane |e verfasserin |4 aut | |
| 700 | 1 | |a Sykes, Michelle |e verfasserin |4 aut | |
| 700 | 1 | |a Teele, Sarah A |e verfasserin |4 aut | |
| 700 | 1 | |a Wernovsky, Gil |e verfasserin |4 aut | |
| 700 | 1 | |a Wray, Jo |e verfasserin |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies |d 2000 |g 24(2023), 5 vom: 01. Mai, Seite 391-398 |w (DE-627)NLM124299717 |x 1529-7535 |7 nnns |
| 773 | 1 | 8 | |g volume:24 |g year:2023 |g number:5 |g day:01 |g month:05 |g pages:391-398 |
| 856 | 4 | 0 | |u http://dx.doi.org/10.1097/PCC.0000000000003190 |3 Volltext |
| 912 | |a GBV_USEFLAG_A | ||
| 912 | |a GBV_NLM | ||
| 951 | |a AR | ||
| 952 | |d 24 |j 2023 |e 5 |b 01 |c 05 |h 391-398 | ||