Clinical course and features of persistent polyclonal B-cell lymphocytosis with BCL-6 amplification during pregnancy
BACKGROUND: Persistent polyclonal B-cell lymphocytosis is a rare nonmalignant disorder characterized by mild persistent lymphocyte proliferation with possible evolution to aggressive lymphoma. Its biology is not well known, but it is characterized by a specific immunophenotype with rearrangement of the BCL-2/IGH gene, whereas amplification of the BCL-6 gene has rarely been reported. Given the paucity of reports, it has been hypothesized that this disorder is associated with poor pregnancy outcomes.
CASE REPORT: To our knowledge, only two successful pregnancies have been described in women with this condition. We report the third successful pregnancy in a patient with PPBL and the first with amplification of the BCL-6 gene.
CONCLUSIONS: PPBL is still a poorly understood clinical condition with insufficient data to demonstrate an adverse effect on pregnancy. The role of BCL-6 dysregulation in the pathogenesis of PPBL and its prognostic significance are still unknown. Evolution into aggressive clonal lymphoproliferative disorders is possible and prolonged hematologic follow-up is warranted in patients with this rare clinical disorder.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2023 |
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| Erschienen: |
2023 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:27 |
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| Enthalten in: |
European review for medical and pharmacological sciences - 27(2023), 8 vom: 28. Apr., Seite 3514-3518 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Galitzia, A [VerfasserIn] |
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| Anmerkungen: |
Date Completed 11.05.2023 Date Revised 18.08.2023 published: Print Citation Status MEDLINE |
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| doi: |
10.26355/eurrev_202304_32124 |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM356435792 |
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| 245 | 1 | 0 | |a Clinical course and features of persistent polyclonal B-cell lymphocytosis with BCL-6 amplification during pregnancy |
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| 500 | |a Date Completed 11.05.2023 | ||
| 500 | |a Date Revised 18.08.2023 | ||
| 500 | |a published: Print | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a BACKGROUND: Persistent polyclonal B-cell lymphocytosis is a rare nonmalignant disorder characterized by mild persistent lymphocyte proliferation with possible evolution to aggressive lymphoma. Its biology is not well known, but it is characterized by a specific immunophenotype with rearrangement of the BCL-2/IGH gene, whereas amplification of the BCL-6 gene has rarely been reported. Given the paucity of reports, it has been hypothesized that this disorder is associated with poor pregnancy outcomes | ||
| 520 | |a CASE REPORT: To our knowledge, only two successful pregnancies have been described in women with this condition. We report the third successful pregnancy in a patient with PPBL and the first with amplification of the BCL-6 gene | ||
| 520 | |a CONCLUSIONS: PPBL is still a poorly understood clinical condition with insufficient data to demonstrate an adverse effect on pregnancy. The role of BCL-6 dysregulation in the pathogenesis of PPBL and its prognostic significance are still unknown. Evolution into aggressive clonal lymphoproliferative disorders is possible and prolonged hematologic follow-up is warranted in patients with this rare clinical disorder | ||
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| 700 | 1 | |a Barabino, L |e verfasserin |4 aut | |
| 700 | 1 | |a Azzena, A |e verfasserin |4 aut | |
| 700 | 1 | |a Licheri, V M |e verfasserin |4 aut | |
| 700 | 1 | |a Greco, M |e verfasserin |4 aut | |
| 700 | 1 | |a La Nasa, G |e verfasserin |4 aut | |
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