Hyperfunctioning papillary thyroid carcinoma - a case report and literature review
BACKGROUND: Malignant hyperfunctioning thyroid nodules are rare and more likely to occur in follicular cancer types rather than papillary variants. The authors present a case of a papillary thyroid carcinoma associated with a hyperfunctioning nodule.
METHODS: A single adult patient submitted to total thyroidectomy with the presence of thyroid carcinoma within hyperfunctioning nodules was selected. Additionally, brief literature was conducted.
RESULTS: An asymptomatic 58-year-old male was subjected to routine blood analysis and a TSH level of <0.003 mIU/L was found. Ultrasonography revealed a 21 mm solid, hypoechoic, and heterogenous nodule with microcalcifications in the right lobe. A fine needle aspiration guided by ultrasound resulted in a follicular lesion of undetermined significance. A 99mTc thyroid scintigram was followed and identified a right-sided hyperfunctioning nodule. Another cytology was performed and a papillary thyroid carcinoma was derived as a result. The patient underwent a total thyroidectomy. Postoperative histology confirmed the diagnosis and a tumor-free margin with no vascular or capsular invasions.
CONCLUSION: Hyperfunctioning malignant nodules are a rare association, although a careful approach should be led since major clinical implications arise. Selective fine needle aspiration in all suspicious ≥1 cm nodules should be considered.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2024 |
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| Erschienen: |
2024 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:124 |
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| Enthalten in: |
Acta chirurgica Belgica - 124(2024), 2 vom: 19. März, Seite 147-152 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Pereira-Macedo, Juliana [VerfasserIn] |
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| Links: |
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| Themen: |
Case Reports |
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| Anmerkungen: |
Date Completed 12.03.2024 Date Revised 12.03.2024 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1080/00015458.2023.2210699 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM356366502 |
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| 500 | |a Date Revised 12.03.2024 | ||
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| 500 | |a Citation Status MEDLINE | ||
| 520 | |a BACKGROUND: Malignant hyperfunctioning thyroid nodules are rare and more likely to occur in follicular cancer types rather than papillary variants. The authors present a case of a papillary thyroid carcinoma associated with a hyperfunctioning nodule | ||
| 520 | |a METHODS: A single adult patient submitted to total thyroidectomy with the presence of thyroid carcinoma within hyperfunctioning nodules was selected. Additionally, brief literature was conducted | ||
| 520 | |a RESULTS: An asymptomatic 58-year-old male was subjected to routine blood analysis and a TSH level of <0.003 mIU/L was found. Ultrasonography revealed a 21 mm solid, hypoechoic, and heterogenous nodule with microcalcifications in the right lobe. A fine needle aspiration guided by ultrasound resulted in a follicular lesion of undetermined significance. A 99mTc thyroid scintigram was followed and identified a right-sided hyperfunctioning nodule. Another cytology was performed and a papillary thyroid carcinoma was derived as a result. The patient underwent a total thyroidectomy. Postoperative histology confirmed the diagnosis and a tumor-free margin with no vascular or capsular invasions | ||
| 520 | |a CONCLUSION: Hyperfunctioning malignant nodules are a rare association, although a careful approach should be led since major clinical implications arise. Selective fine needle aspiration in all suspicious ≥1 cm nodules should be considered | ||
| 650 | 4 | |a Review | |
| 650 | 4 | |a Case Reports | |
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Thyroid nodule | |
| 650 | 4 | |a hot nodule | |
| 650 | 4 | |a hyperthyroidism | |
| 650 | 4 | |a malignant nodule | |
| 650 | 4 | |a thyroid tumor | |
| 700 | 1 | |a Freire, Bárbara |e verfasserin |4 aut | |
| 700 | 1 | |a Macedo-Oliveira, Carlos |e verfasserin |4 aut | |
| 700 | 1 | |a Mendes, João |e verfasserin |4 aut | |
| 700 | 1 | |a Carvalho, Márcia |e verfasserin |4 aut | |
| 700 | 1 | |a Rocha-Neves, João |e verfasserin |4 aut | |
| 700 | 1 | |a Fonseca, Sofia |e verfasserin |4 aut | |
| 700 | 1 | |a Vinagreiro, Margarida |e verfasserin |4 aut | |
| 700 | 1 | |a Lemos, Ricardo |e verfasserin |4 aut | |
| 700 | 1 | |a Silva, Nair |e verfasserin |4 aut | |
| 700 | 1 | |a Sampaio, Francisco |e verfasserin |4 aut | |
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