Early SARS-CoV-2 Reinfections Involving the Same or Different Genomic Lineages, Spain
Centers for Disease Control and Prevention guidelines consider SARS-CoV-2 reinfection when sequential COVID-19 episodes occur >90 days apart. However, genomic diversity acquired over recent COVID-19 waves could mean previous infection provides insufficient cross-protection. We used genomic analysis to assess the percentage of early reinfections in a sample of 26 patients with 2 COVID-19 episodes separated by 20-45 days. Among sampled patients, 11 (42%) had reinfections involving different SARS-CoV-2 variants or subvariants. Another 4 cases were probable reinfections; 3 involved different strains from the same lineage or sublineage. Host genomic analysis confirmed the 2 sequential specimens belonged to the same patient. Among all reinfections, 36.4% involved non-Omicron, then Omicron lineages. Early reinfections showed no specific clinical patterns; 45% were among unvaccinated or incompletely vaccinated persons, 27% were among persons <18 years of age, and 64% of patients had no risk factors. Time between sequential positive SARS-CoV-2 PCRs to consider reinfection should be re-evaluated.
| Medienart: |
E-Artikel |
|---|
| Erscheinungsjahr: |
2023 |
|---|---|
| Erschienen: |
2023 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:29 |
|---|---|
| Enthalten in: |
Emerging infectious diseases - 29(2023), 6 vom: 15. Juni, Seite 1154-1161 |
| Sprache: |
Englisch |
|---|
| Beteiligte Personen: |
Rodríguez-Grande, Cristina [VerfasserIn] |
|---|
| Links: |
|---|
| Themen: |
COVID-19 |
|---|
| Anmerkungen: |
Date Completed 22.05.2023 Date Revised 02.06.2023 published: Print-Electronic Citation Status MEDLINE |
|---|
| doi: |
10.3201/eid2906.221696 |
|---|
| funding: |
|
|---|---|
| Förderinstitution / Projekttitel: |
|
| PPN (Katalog-ID): |
NLM356338207 |
|---|
| LEADER | 01000naa a22002652 4500 | ||
|---|---|---|---|
| 001 | NLM356338207 | ||
| 003 | DE-627 | ||
| 005 | 20231226070239.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 231226s2023 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.3201/eid2906.221696 |2 doi | |
| 028 | 5 | 2 | |a pubmed24n1187.xml |
| 035 | |a (DE-627)NLM356338207 | ||
| 035 | |a (NLM)37130503 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
| 041 | |a eng | ||
| 100 | 1 | |a Rodríguez-Grande, Cristina |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Early SARS-CoV-2 Reinfections Involving the Same or Different Genomic Lineages, Spain |
| 264 | 1 | |c 2023 | |
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a ƒaComputermedien |b c |2 rdamedia | ||
| 338 | |a ƒa Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Date Completed 22.05.2023 | ||
| 500 | |a Date Revised 02.06.2023 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a Centers for Disease Control and Prevention guidelines consider SARS-CoV-2 reinfection when sequential COVID-19 episodes occur >90 days apart. However, genomic diversity acquired over recent COVID-19 waves could mean previous infection provides insufficient cross-protection. We used genomic analysis to assess the percentage of early reinfections in a sample of 26 patients with 2 COVID-19 episodes separated by 20-45 days. Among sampled patients, 11 (42%) had reinfections involving different SARS-CoV-2 variants or subvariants. Another 4 cases were probable reinfections; 3 involved different strains from the same lineage or sublineage. Host genomic analysis confirmed the 2 sequential specimens belonged to the same patient. Among all reinfections, 36.4% involved non-Omicron, then Omicron lineages. Early reinfections showed no specific clinical patterns; 45% were among unvaccinated or incompletely vaccinated persons, 27% were among persons <18 years of age, and 64% of patients had no risk factors. Time between sequential positive SARS-CoV-2 PCRs to consider reinfection should be re-evaluated | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Research Support, Non-U.S. Gov't | |
| 650 | 4 | |a COVID-19 | |
| 650 | 4 | |a SARS | |
| 650 | 4 | |a SARS-CoV-2 | |
| 650 | 4 | |a Spain | |
| 650 | 4 | |a coronavirus | |
| 650 | 4 | |a coronavirus disease | |
| 650 | 4 | |a respiratory infections | |
| 650 | 4 | |a severe acute respiratory syndrome coronavirus 2 | |
| 650 | 4 | |a viruses | |
| 650 | 4 | |a zoonoses | |
| 700 | 1 | |a Estévez, Agustín |e verfasserin |4 aut | |
| 700 | 1 | |a Palomino-Cabrera, Rosalía |e verfasserin |4 aut | |
| 700 | 1 | |a Molero-Salinas, Andrea |e verfasserin |4 aut | |
| 700 | 1 | |a Peñas-Utrilla, Daniel |e verfasserin |4 aut | |
| 700 | 1 | |a Herranz, Marta |e verfasserin |4 aut | |
| 700 | 1 | |a Sanz-Pérez, Amadeo |e verfasserin |4 aut | |
| 700 | 1 | |a Alcalá, Luis |e verfasserin |4 aut | |
| 700 | 1 | |a Veintimilla, Cristina |e verfasserin |4 aut | |
| 700 | 1 | |a Catalán, Pilar |e verfasserin |4 aut | |
| 700 | 1 | |a Martínez-Laperche, Carolina |e verfasserin |4 aut | |
| 700 | 1 | |a Alonso, Roberto |e verfasserin |4 aut | |
| 700 | 1 | |a Muñoz, Patricia |e verfasserin |4 aut | |
| 700 | 1 | |a Pérez-Lago, Laura |e verfasserin |4 aut | |
| 700 | 1 | |a de Viedma, Darío García |e verfasserin |4 aut | |
| 700 | 0 | |a Gregorio Marañón Microbiology-ID COVID 19 Study Group |e verfasserin |4 aut | |
| 700 | 1 | |a Aldámiz, Teresa |e investigator |4 oth | |
| 700 | 1 | |a Álvarez-Uría, Ana |e investigator |4 oth | |
| 700 | 1 | |a Bermúdez, Elena |e investigator |4 oth | |
| 700 | 1 | |a Bouza, Emilio |e investigator |4 oth | |
| 700 | 1 | |a Buenestado-Serrano, Sergio |e investigator |4 oth | |
| 700 | 1 | |a Burillo, Almudena |e investigator |4 oth | |
| 700 | 1 | |a Carrillo, Raquel |e investigator |4 oth | |
| 700 | 1 | |a Cercenado, Emilia |e investigator |4 oth | |
| 700 | 1 | |a Cobos, Alejandro |e investigator |4 oth | |
| 700 | 1 | |a Díez, Cristina |e investigator |4 oth | |
| 700 | 1 | |a Escribano, Pilar |e investigator |4 oth | |
| 700 | 1 | |a Fanciulli, Chiara |e investigator |4 oth | |
| 700 | 1 | |a Galar, Alicia |e investigator |4 oth | |
| 700 | 1 | |a García, Mᵃ Dolores |e investigator |4 oth | |
| 700 | 1 | |a Gijón, Paloma |e investigator |4 oth | |
| 700 | 1 | |a Guillén, Helmuth |e investigator |4 oth | |
| 700 | 1 | |a Guinea, Jesús |e investigator |4 oth | |
| 700 | 1 | |a Irigoyen, Álvaro |e investigator |4 oth | |
| 700 | 1 | |a Kestler, Martha |e investigator |4 oth | |
| 700 | 1 | |a López, Juan Carlos |e investigator |4 oth | |
| 700 | 1 | |a Machado, Marina |e investigator |4 oth | |
| 700 | 1 | |a Marín, Mercedes |e investigator |4 oth | |
| 700 | 1 | |a Martín-Rabadán, Pablo |e investigator |4 oth | |
| 700 | 1 | |a Montilla, Pedro |e investigator |4 oth | |
| 700 | 1 | |a Padilla, Belén |e investigator |4 oth | |
| 700 | 1 | |a Palomo, María |e investigator |4 oth | |
| 700 | 1 | |a Pérez-Granda, María Jesús |e investigator |4 oth | |
| 700 | 1 | |a Pérez, Leire |e investigator |4 oth | |
| 700 | 1 | |a Reigadas, Elena |e investigator |4 oth | |
| 700 | 1 | |a Rincón, Cristina |e investigator |4 oth | |
| 700 | 1 | |a Rodríguez, Belén |e investigator |4 oth | |
| 700 | 1 | |a Rodríguez, Sara |e investigator |4 oth | |
| 700 | 1 | |a Rojas, Adriana |e investigator |4 oth | |
| 700 | 1 | |a Ruiz-Serrano, María Jesús |e investigator |4 oth | |
| 700 | 1 | |a Sánchez, Carlos |e investigator |4 oth | |
| 700 | 1 | |a Sánchez, Mar |e investigator |4 oth | |
| 700 | 1 | |a Serrano, Julia |e investigator |4 oth | |
| 700 | 1 | |a Tejerina, Francisco |e investigator |4 oth | |
| 700 | 1 | |a Valerio, Maricela |e investigator |4 oth | |
| 700 | 1 | |a Vesperinas, Lara |e investigator |4 oth | |
| 700 | 1 | |a Vicente, Teresa |e investigator |4 oth | |
| 700 | 1 | |a de la Villa, Sofía |e investigator |4 oth | |
| 773 | 0 | 8 | |i Enthalten in |t Emerging infectious diseases |d 1995 |g 29(2023), 6 vom: 15. Juni, Seite 1154-1161 |w (DE-627)NLM088704254 |x 1080-6059 |7 nnns |
| 773 | 1 | 8 | |g volume:29 |g year:2023 |g number:6 |g day:15 |g month:06 |g pages:1154-1161 |
| 856 | 4 | 0 | |u http://dx.doi.org/10.3201/eid2906.221696 |3 Volltext |
| 912 | |a GBV_USEFLAG_A | ||
| 912 | |a GBV_NLM | ||
| 951 | |a AR | ||
| 952 | |d 29 |j 2023 |e 6 |b 15 |c 06 |h 1154-1161 | ||