Chitooligosaccharide-catechin conjugate loaded liposome using different stabilising agents : characteristics, stability, and bioactivities
AIM: To determine the optimum condition for preparing chitooligosaccharide-catechin conjugate (COS-CAT) liposomes using different stabilising agents.
METHODS: COS-CAT liposomes (0.1-1%, w/v) were prepared using soy phosphatidylcholine (SPC) (50-200 mM) and glycerol or cholesterol (25-100 mg). Encapsulation efficiency (EE), loading capacity (LC), physicochemical characteristics, FTIR spectra, thermal stability, and structure of COS-CAT liposomes were assessed.
RESULTS: COS-CAT loaded liposome stabilised by cholesterol (COS-CAT-CHO) showed higher stability as shown by the highest EE (76.81%) and LC (4.57%) and the lowest zeta potential (ZP) (-76.51 mV), polydispersity index (PDI) (0.2674) and releasing efficiency (RE) (53.54%) (p < 0.05). COS-CAT-CHO showed the highest retention and relative remaining bioactivities of COS-CAT under various conditions (p < 0.05). FTIR spectra revealed the interaction between the choline group of SPC and -OH groups of COS-CAT. Phase transition temperature of COS-CAT-CHO was shifted to 184 °C, which was higher than others (p < 0.05).
CONCLUSION: SPC and cholesterol-based liposome could be used as a promising vesicle for maintaining bioactivities of COS-CAT.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2023 |
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| Erschienen: |
2023 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:40 |
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| Enthalten in: |
Journal of microencapsulation - 40(2023), 6 vom: 12. Sept., Seite 385-401 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Mittal, Ajay [VerfasserIn] |
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| Links: |
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| Themen: |
1398-61-4 |
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| Anmerkungen: |
Date Completed 15.08.2023 Date Revised 15.08.2023 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1080/02652048.2023.2209658 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM356334031 |
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| 100 | 1 | |a Mittal, Ajay |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Chitooligosaccharide-catechin conjugate loaded liposome using different stabilising agents |b characteristics, stability, and bioactivities |
| 264 | 1 | |c 2023 | |
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| 500 | |a Date Completed 15.08.2023 | ||
| 500 | |a Date Revised 15.08.2023 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a AIM: To determine the optimum condition for preparing chitooligosaccharide-catechin conjugate (COS-CAT) liposomes using different stabilising agents | ||
| 520 | |a METHODS: COS-CAT liposomes (0.1-1%, w/v) were prepared using soy phosphatidylcholine (SPC) (50-200 mM) and glycerol or cholesterol (25-100 mg). Encapsulation efficiency (EE), loading capacity (LC), physicochemical characteristics, FTIR spectra, thermal stability, and structure of COS-CAT liposomes were assessed | ||
| 520 | |a RESULTS: COS-CAT loaded liposome stabilised by cholesterol (COS-CAT-CHO) showed higher stability as shown by the highest EE (76.81%) and LC (4.57%) and the lowest zeta potential (ZP) (-76.51 mV), polydispersity index (PDI) (0.2674) and releasing efficiency (RE) (53.54%) (p < 0.05). COS-CAT-CHO showed the highest retention and relative remaining bioactivities of COS-CAT under various conditions (p < 0.05). FTIR spectra revealed the interaction between the choline group of SPC and -OH groups of COS-CAT. Phase transition temperature of COS-CAT-CHO was shifted to 184 °C, which was higher than others (p < 0.05) | ||
| 520 | |a CONCLUSION: SPC and cholesterol-based liposome could be used as a promising vesicle for maintaining bioactivities of COS-CAT | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Chitooligosaccharide | |
| 650 | 4 | |a antioxidant | |
| 650 | 4 | |a bioactivity | |
| 650 | 4 | |a catechin | |
| 650 | 4 | |a conjugate | |
| 650 | 4 | |a in vitro digestion | |
| 650 | 4 | |a liposome | |
| 650 | 4 | |a stability | |
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| 700 | 1 | |a Hong, Hui |e verfasserin |4 aut | |
| 700 | 1 | |a Benjakul, Soottawat |e verfasserin |4 aut | |
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