Mesenchymal Stromal Cells Facilitate Tip Cell Fusion Downstream of BMP-Mediated Venous Angiogenesis-Brief Report
BACKGROUND: The goal of this study was to identify and characterize cell-cell interactions that facilitate endothelial tip cell fusion downstream of BMP (bone morphogenic protein)-mediated venous plexus formation.
METHODS: High resolution and time-lapse imaging of transgenic reporter lines and loss-of-function studies were carried out to study the involvement of mesenchymal stromal cells during venous angiogenesis.
RESULTS: BMP-responsive stromal cells facilitate timely and precise fusion of venous tip cells during developmental angiogenesis.
CONCLUSIONS: Stromal cells are required for anastomosis of venous tip cells in the embryonic caudal hematopoietic tissue.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2023 |
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| Erschienen: |
2023 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:43 |
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| Enthalten in: |
Arteriosclerosis, thrombosis, and vascular biology - 43(2023), 7 vom: 04. Juli, Seite e231-e237 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Eisa-Beygi, Shahram [VerfasserIn] |
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| Links: |
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| Themen: |
Anastomosis |
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| Anmerkungen: |
Date Completed 23.06.2023 Date Revised 11.07.2023 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1161/ATVBAHA.122.318622 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM356322548 |
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| 245 | 1 | 0 | |a Mesenchymal Stromal Cells Facilitate Tip Cell Fusion Downstream of BMP-Mediated Venous Angiogenesis-Brief Report |
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| 500 | |a Date Completed 23.06.2023 | ||
| 500 | |a Date Revised 11.07.2023 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a BACKGROUND: The goal of this study was to identify and characterize cell-cell interactions that facilitate endothelial tip cell fusion downstream of BMP (bone morphogenic protein)-mediated venous plexus formation | ||
| 520 | |a METHODS: High resolution and time-lapse imaging of transgenic reporter lines and loss-of-function studies were carried out to study the involvement of mesenchymal stromal cells during venous angiogenesis | ||
| 520 | |a RESULTS: BMP-responsive stromal cells facilitate timely and precise fusion of venous tip cells during developmental angiogenesis | ||
| 520 | |a CONCLUSIONS: Stromal cells are required for anastomosis of venous tip cells in the embryonic caudal hematopoietic tissue | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Research Support, N.I.H., Extramural | |
| 650 | 4 | |a anastomosis | |
| 650 | 4 | |a angiogenesis | |
| 650 | 4 | |a arteriovenous development | |
| 650 | 4 | |a mesenchymal stromal cells | |
| 650 | 4 | |a zebrafish | |
| 650 | 7 | |a Bone Morphogenetic Proteins |2 NLM | |
| 700 | 1 | |a Hu, Meng-Ming |e verfasserin |4 aut | |
| 700 | 1 | |a Kumar, Suresh N |e verfasserin |4 aut | |
| 700 | 1 | |a Jeffery, Brooke E |e verfasserin |4 aut | |
| 700 | 1 | |a Collery, Ross F |e verfasserin |4 aut | |
| 700 | 1 | |a Vo, Nghia Jack |e verfasserin |4 aut | |
| 700 | 1 | |a Lamichanne, Bhawika S |e verfasserin |4 aut | |
| 700 | 1 | |a Yost, H Joseph |e verfasserin |4 aut | |
| 700 | 1 | |a Veldman, Matthew B |e verfasserin |4 aut | |
| 700 | 1 | |a Link, Brian A |e verfasserin |4 aut | |
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