Prevalence and clinical relevance of VZV lung detection in intensive care unit : A retrospective cohort study
Copyright © 2023 Elsevier B.V. All rights reserved..
OBJECTIVE: To assess the clinical relevance of varicella zoster virus (VZV) lung detection among patients hospitalized in intensive care unit (ICU).
METHODS: We present a monocentric retrospective cohort study from 2012 to 2020. VZV genome was detected in bronchoalveolar lavage (BAL) fluid by real-time PCR.
RESULTS: Twelve of 1389 (0.8%) patients exhibited VZV lung detection, corresponding to an incidence of 13.4 (95% confidence interval [CI] 5.8-21.0) per 100 person-years. Immunosuppression and prolonged ICU stay constituted the main risks factors. VZV detection was not associated with pulmonary deterioration but associated with a risk of shingles occurrence during the following days.
CONCLUSION: VZV lung detection is a rare event among ICU patients, occurring mostly in immunocompromised patients with prolonged ICU stay. Due to its scarcity and the lack of association with pulmonary failure, a targeted approach to the VZV lung detection diagnosis may allow a significant cost saving without affecting the quality of patients care.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2023 |
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| Erschienen: |
2023 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:164 |
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| Enthalten in: |
Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology - 164(2023) vom: 15. Juli, Seite 105470 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Guiraud, Vincent [VerfasserIn] |
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| Links: |
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| Themen: |
Intensive care unit |
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| Anmerkungen: |
Date Completed 09.06.2023 Date Revised 11.06.2023 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1016/j.jcv.2023.105470 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM356243052 |
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| 100 | 1 | |a Guiraud, Vincent |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Prevalence and clinical relevance of VZV lung detection in intensive care unit |b A retrospective cohort study |
| 264 | 1 | |c 2023 | |
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| 500 | |a Date Completed 09.06.2023 | ||
| 500 | |a Date Revised 11.06.2023 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a Copyright © 2023 Elsevier B.V. All rights reserved. | ||
| 520 | |a OBJECTIVE: To assess the clinical relevance of varicella zoster virus (VZV) lung detection among patients hospitalized in intensive care unit (ICU) | ||
| 520 | |a METHODS: We present a monocentric retrospective cohort study from 2012 to 2020. VZV genome was detected in bronchoalveolar lavage (BAL) fluid by real-time PCR | ||
| 520 | |a RESULTS: Twelve of 1389 (0.8%) patients exhibited VZV lung detection, corresponding to an incidence of 13.4 (95% confidence interval [CI] 5.8-21.0) per 100 person-years. Immunosuppression and prolonged ICU stay constituted the main risks factors. VZV detection was not associated with pulmonary deterioration but associated with a risk of shingles occurrence during the following days | ||
| 520 | |a CONCLUSION: VZV lung detection is a rare event among ICU patients, occurring mostly in immunocompromised patients with prolonged ICU stay. Due to its scarcity and the lack of association with pulmonary failure, a targeted approach to the VZV lung detection diagnosis may allow a significant cost saving without affecting the quality of patients care | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Intensive care unit | |
| 650 | 4 | |a Lung | |
| 650 | 4 | |a Pneumonia | |
| 650 | 4 | |a Reactivation | |
| 650 | 4 | |a Varicella zoster virus (VZV) | |
| 700 | 1 | |a Burrel, Sonia |e verfasserin |4 aut | |
| 700 | 1 | |a Luyt, Charles-Edouard |e verfasserin |4 aut | |
| 700 | 1 | |a Boutolleau, David |e verfasserin |4 aut | |
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