Details der Publikation - Controversy and Consensus on Indications for Sperm DNA Fragmentation Testing in Male Infertility

Controversy and Consensus on Indications for Sperm DNA Fragmentation Testing in Male Infertility : A Global Survey, Current Guidelines, and Expert Recommendations

Copyright © 2023 Korean Society for Sexual Medicine and Andrology..

PURPOSE: Sperm DNA fragmentation (SDF) testing was recently added to the sixth edition of the World Health Organization laboratory manual for the examination and processing of human semen. Many conditions and risk factors have been associated with elevated SDF; therefore, it is important to identify the population of infertile men who might benefit from this test. The purpose of this study was to investigate global practices related to indications for SDF testing, compare the relevant professional society guideline recommendations, and provide expert recommendations.

MATERIALS AND METHODS: Clinicians managing male infertility were invited to take part in a global online survey on SDF clinical practices. This was conducted following the CHERRIES checklist criteria. The responses were compared to professional society guideline recommendations related to SDF and the appropriate available evidence. Expert recommendations on indications for SDF testing were then formulated, and the Delphi method was used to reach consensus.

RESULTS: The survey was completed by 436 experts from 55 countries. Almost 75% of respondents test for SDF in all or some men with unexplained or idiopathic infertility, 39% order it routinely in the work-up of recurrent pregnancy loss (RPL), and 62.2% investigate SDF in smokers. While 47% of reproductive urologists test SDF to support the decision for varicocele repair surgery when conventional semen parameters are normal, significantly fewer general urologists (23%; p=0.008) do the same. Nearly 70% would assess SDF before assisted reproductive technologies (ART), either always or for certain conditions. Recurrent ART failure is a common indication for SDF testing. Very few society recommendations were found regarding SDF testing.

CONCLUSIONS: This article presents the largest global survey on the indications for SDF testing in infertile men, and demonstrates diverse practices. Furthermore, it highlights the paucity of professional society guideline recommendations. Expert recommendations are proposed to help guide clinicians.

Medienart:	E-Artikel

Erscheinungsjahr:	2023
Erschienen:	2023

Enthalten in:	Zur Gesamtaufnahme - volume:41
Enthalten in:	The world journal of men's health - 41(2023), 3 vom: 20. Juli, Seite 575-602

Sprache:	Englisch

Beteiligte Personen:	Agarwal, Ashok [VerfasserIn] Farkouh, Ala'a [VerfasserIn] Saleh, Ramadan [VerfasserIn] Abdel-Meguid Hamoda, Taha Abo-Almagd [VerfasserIn] Harraz, Ahmed M [VerfasserIn] Kavoussi, Parviz [VerfasserIn] Arafa, Mohamed [VerfasserIn] Salvio, Gianmaria [VerfasserIn] Rambhatla, Amarnath [VerfasserIn] Toprak, Tuncay [VerfasserIn] Gül, Murat [VerfasserIn] Phuoc, Nguyen Ho Vinh [VerfasserIn] Boitrelle, Florence [VerfasserIn] Birowo, Ponco [VerfasserIn] Ghayda, Ramy Abou [VerfasserIn] Cannarella, Rossella [VerfasserIn] Kuroda, Shinnosuke [VerfasserIn] Durairajanayagam, Damayanthi [VerfasserIn] Zini, Armand [VerfasserIn] Wyns, Christine [VerfasserIn] Sarikaya, Selcuk [VerfasserIn] Tremellen, Kelton [VerfasserIn] Mostafa, Taymour [VerfasserIn] Sokolakis, Ioannis [VerfasserIn] Evenson, Donald P [VerfasserIn] Henkel, Ralf [VerfasserIn] Zohdy, Wael [VerfasserIn] Chung, Eric [VerfasserIn] Ziouziou, Imad [VerfasserIn] Falcone, Marco [VerfasserIn] Russo, Giorgio I [VerfasserIn] Al-Hashimi, Manaf [VerfasserIn] Calogero, Aldo E [VerfasserIn] Ko, Edmund [VerfasserIn] Colpi, Giovanni [VerfasserIn] Lewis, Sheena [VerfasserIn] Serefoglu, Ege Can [VerfasserIn] Bahar, Fahmi [VerfasserIn] Martinez, Marlon [VerfasserIn] Nguyen, Quang [VerfasserIn] Ambar, Rafael F [VerfasserIn] Bakircioglu, Mustafa Emre [VerfasserIn] Kandil, Hussein [VerfasserIn] Mogharabian, Nasser [VerfasserIn] Sabbaghian, Marjan [VerfasserIn] Taniguchi, Hisanori [VerfasserIn] Tsujimura, Akira [VerfasserIn] Sajadi, Hesamoddin [VerfasserIn] Ibrahim, Wael [VerfasserIn] Atmoko, Widi [VerfasserIn] Vogiatzi, Paraskevi [VerfasserIn] Gunes, Sezgin [VerfasserIn] Sadighi Gilani, Mohammad Ali [VerfasserIn] Roychoudhury, Shubhadeep [VerfasserIn] Güngör, Nur Dokuzeylül [VerfasserIn] Hakim, Lukman [VerfasserIn] Adriansjah, Ricky [VerfasserIn] Kothari, Priyank [VerfasserIn] Jindal, Sunil [VerfasserIn] Amar, Edouard [VerfasserIn] Park, Hyun Jun [VerfasserIn] Long, Tran Quang Tien [VerfasserIn] Homa, Sheryl [VerfasserIn] Karthikeyan, Vilvapathy Senguttuvan [VerfasserIn] Zilaitiene, Birute [VerfasserIn] Maldonado Rosas, Israel [VerfasserIn] Marino, Angelo [VerfasserIn] Pescatori, Edoardo [VerfasserIn] Ozer, Cevahir [VerfasserIn] Akhavizadegan, Hamed [VerfasserIn] Garrido, Nicolas [VerfasserIn] Busetto, Gian Maria [VerfasserIn] Adamyan, Aram [VerfasserIn] Al-Marhoon, Mohamed [VerfasserIn] Elbardisi, Haitham [VerfasserIn] Dolati, Parisa [VerfasserIn] Darbandi, Mahsa [VerfasserIn] Darbandi, Sara [VerfasserIn] Balercia, Giancarlo [VerfasserIn] Pinggera, Germar-Michael [VerfasserIn] Micic, Sava [VerfasserIn] Ho, Christopher Chee Kong [VerfasserIn] Moussa, Mohamad [VerfasserIn] Preto, Mirko [VerfasserIn] Zenoaga-Barbăroșie, Cătălina [VerfasserIn] Smith, Ryan P [VerfasserIn] Kosgi, Raghavender [VerfasserIn] de la Rosette, Jean [VerfasserIn] El-Sakka, Ahmed I [VerfasserIn] Abumelha, Saad Mohammed [VerfasserIn] Mierzwa, Tiago Cesar [VerfasserIn] Ong, Teng Aik [VerfasserIn] Banihani, Saleem A [VerfasserIn] Bowa, Kasonde [VerfasserIn] Fukuhara, Shinichiro [VerfasserIn] Boeri, Luca [VerfasserIn] Danacıoğlu, Yavuz Onur [VerfasserIn] Gokalp, Fatih [VerfasserIn] Selim, Osama Mohamed [VerfasserIn] Cho, Chak-Lam [VerfasserIn] Global Andrology Forum [VerfasserIn] et al [Sonstige Person]

Links:	Volltext

Themen:	DNA fragmentation Delphi method Journal Article Male infertility Practice guidelines Sperm Survey

Anmerkungen:	Date Revised 20.09.2023 published: Print-Electronic Citation Status PubMed-not-MEDLINE

doi:	10.5534/wjmh.220282

funding:
Förderinstitution / Projekttitel:

PPN (Katalog-ID):	NLM356223612

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100	1		\|a Agarwal, Ashok \|e verfasserin \|4 aut
245	1	0	\|a Controversy and Consensus on Indications for Sperm DNA Fragmentation Testing in Male Infertility \|b A Global Survey, Current Guidelines, and Expert Recommendations
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500			\|a Date Revised 20.09.2023
500			\|a published: Print-Electronic
500			\|a Citation Status PubMed-not-MEDLINE
520			\|a Copyright © 2023 Korean Society for Sexual Medicine and Andrology.
520			\|a PURPOSE: Sperm DNA fragmentation (SDF) testing was recently added to the sixth edition of the World Health Organization laboratory manual for the examination and processing of human semen. Many conditions and risk factors have been associated with elevated SDF; therefore, it is important to identify the population of infertile men who might benefit from this test. The purpose of this study was to investigate global practices related to indications for SDF testing, compare the relevant professional society guideline recommendations, and provide expert recommendations
520			\|a MATERIALS AND METHODS: Clinicians managing male infertility were invited to take part in a global online survey on SDF clinical practices. This was conducted following the CHERRIES checklist criteria. The responses were compared to professional society guideline recommendations related to SDF and the appropriate available evidence. Expert recommendations on indications for SDF testing were then formulated, and the Delphi method was used to reach consensus
520			\|a RESULTS: The survey was completed by 436 experts from 55 countries. Almost 75% of respondents test for SDF in all or some men with unexplained or idiopathic infertility, 39% order it routinely in the work-up of recurrent pregnancy loss (RPL), and 62.2% investigate SDF in smokers. While 47% of reproductive urologists test SDF to support the decision for varicocele repair surgery when conventional semen parameters are normal, significantly fewer general urologists (23%; p=0.008) do the same. Nearly 70% would assess SDF before assisted reproductive technologies (ART), either always or for certain conditions. Recurrent ART failure is a common indication for SDF testing. Very few society recommendations were found regarding SDF testing
520			\|a CONCLUSIONS: This article presents the largest global survey on the indications for SDF testing in infertile men, and demonstrates diverse practices. Furthermore, it highlights the paucity of professional society guideline recommendations. Expert recommendations are proposed to help guide clinicians
650		4	\|a Journal Article
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650		4	\|a Practice guidelines
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Controversy and Consensus on Indications for Sperm DNA Fragmentation Testing in Male Infertility : A Global Survey, Current Guidelines, and Expert Recommendations

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