DNA immunization with in silico predicted T-cell epitopes protects against lethal SARS-CoV-2 infection in K18-hACE2 mice
Copyright © 2023 Persson, Restori, Emdrup, Schussek, Klausen, Nicol, Katkere, Rønø, Kirimanjeswara and Sørensen..
The global SARS-CoV-2 pandemic caused significant social and economic disruption worldwide, despite highly effective vaccines being developed at an unprecedented speed. Because the first licensed vaccines target only single B-cell antigens, antigenic drift could lead to loss of efficacy against emerging SARS-CoV-2 variants. Improving B-cell vaccines by including multiple T-cell epitopes could solve this problem. Here, we show that in silico predicted MHC class I/II ligands induce robust T-cell responses and protect against severe disease in genetically modified K18-hACE2/BL6 mice susceptible to SARS-CoV-2 infection.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2023 |
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| Erschienen: |
2023 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:14 |
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| Enthalten in: |
Frontiers in immunology - 14(2023) vom: 24., Seite 1166546 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Persson, Gry [VerfasserIn] |
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| Links: |
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| Anmerkungen: |
Date Completed 03.05.2023 Date Revised 03.05.2023 published: Electronic-eCollection Citation Status MEDLINE |
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| doi: |
10.3389/fimmu.2023.1166546 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM356176258 |
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| 520 | |a Copyright © 2023 Persson, Restori, Emdrup, Schussek, Klausen, Nicol, Katkere, Rønø, Kirimanjeswara and Sørensen. | ||
| 520 | |a The global SARS-CoV-2 pandemic caused significant social and economic disruption worldwide, despite highly effective vaccines being developed at an unprecedented speed. Because the first licensed vaccines target only single B-cell antigens, antigenic drift could lead to loss of efficacy against emerging SARS-CoV-2 variants. Improving B-cell vaccines by including multiple T-cell epitopes could solve this problem. Here, we show that in silico predicted MHC class I/II ligands induce robust T-cell responses and protect against severe disease in genetically modified K18-hACE2/BL6 mice susceptible to SARS-CoV-2 infection | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Research Support, Non-U.S. Gov't | |
| 650 | 4 | |a COVID-19 | |
| 650 | 4 | |a SARS-CoV-2 | |
| 650 | 4 | |a T-cell vaccine | |
| 650 | 4 | |a machine learning | |
| 650 | 4 | |a viral challenge model | |
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| 650 | 7 | |a Epitopes, T-Lymphocyte |2 NLM | |
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| 700 | 1 | |a Restori, Katherine H |e verfasserin |4 aut | |
| 700 | 1 | |a Emdrup, Julie Hincheli |e verfasserin |4 aut | |
| 700 | 1 | |a Schussek, Sophie |e verfasserin |4 aut | |
| 700 | 1 | |a Klausen, Michael Schantz |e verfasserin |4 aut | |
| 700 | 1 | |a Nicol, McKayla J |e verfasserin |4 aut | |
| 700 | 1 | |a Katkere, Bhuvana |e verfasserin |4 aut | |
| 700 | 1 | |a Rønø, Birgitte |e verfasserin |4 aut | |
| 700 | 1 | |a Kirimanjeswara, Girish |e verfasserin |4 aut | |
| 700 | 1 | |a Sørensen, Anders Bundgaard |e verfasserin |4 aut | |
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