Solid-state characterization of ibuprofen-isonicotinamide cocrystals prepared by electrospraying and solvent evaporation
Aim: Electrospraying (ELS) was used to prepare micronized ibuprofen-isonicotinamide cocrystal (IBU-INA-ELS) and its properties were compared with the solvent evaporated cocrystal (IBU-INA-SE). Methods: Solid-state characterization of crystalline phase, production yield, particle size, powder flow, wettability, solution mediated phase transformation (SMPT), and dissolution rate were measured. Results: The ELS produced phase pure particles of IBU-INA with a size of 1.46 μm and yield of 72.3%. This cocrystal improved the intrinsic dissolution rate and powder dissolution rate of IBU by 3.6- and 1.7-fold, respectively. Our experiments showed that the dissolution of IBU-INA was affected by particle size, solubility, SMPT and wettability. Conclusion: ELS produced micronized cocrystals for improving dissolution of ibuprofen with a high yield in a single step and mild conditions.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2023 |
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| Erschienen: |
2023 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:14 |
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| Enthalten in: |
Therapeutic delivery - 14(2023), 2 vom: 22. Feb., Seite 121-138 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Ghafari, Reza [VerfasserIn] |
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| Links: |
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| Anmerkungen: |
Date Completed 12.05.2023 Date Revised 04.06.2023 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.4155/tde-2022-0072 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM356023281 |
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| 245 | 1 | 0 | |a Solid-state characterization of ibuprofen-isonicotinamide cocrystals prepared by electrospraying and solvent evaporation |
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| 500 | |a Date Revised 04.06.2023 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a Aim: Electrospraying (ELS) was used to prepare micronized ibuprofen-isonicotinamide cocrystal (IBU-INA-ELS) and its properties were compared with the solvent evaporated cocrystal (IBU-INA-SE). Methods: Solid-state characterization of crystalline phase, production yield, particle size, powder flow, wettability, solution mediated phase transformation (SMPT), and dissolution rate were measured. Results: The ELS produced phase pure particles of IBU-INA with a size of 1.46 μm and yield of 72.3%. This cocrystal improved the intrinsic dissolution rate and powder dissolution rate of IBU by 3.6- and 1.7-fold, respectively. Our experiments showed that the dissolution of IBU-INA was affected by particle size, solubility, SMPT and wettability. Conclusion: ELS produced micronized cocrystals for improving dissolution of ibuprofen with a high yield in a single step and mild conditions | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Research Support, Non-U.S. Gov't | |
| 650 | 4 | |a cocrystal | |
| 650 | 4 | |a dissolution | |
| 650 | 4 | |a electrospraying | |
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