Association of TLR4 and TLR9 gene polymorphisms with the risk and progression of cervical lesions in HPV-infected women
Aim: Toll-like receptors involved in tumor-associated inflammatory response, this study aimed to investigate the role of TLR4 and TLR9 gene polymorphisms in the risk and progression of HPV-related cervical lesions. Materials & methods: A total of 220 cervical lesion patients and 227 healthy controls were enrolled. Single-nucleotide polymorphisms were genotyped using PCR-restriction fragment length polymorphism. Results: A significantly decreased risk of cervical lesions was observed to be associated with the TLR4 rs10116253 (C), rs1927911 (T) and rs10759931 (G) mutant alleles. rs187084-rs1927911-HPV-16/18 was the best interaction model to affect cervical lesion risk. Conclusion: TLR4 rs10116253, rs1927911 and rs10759931 were potential biomarkers for cervical lesion susceptibility.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2023 |
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| Erschienen: |
2023 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:17 |
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| Enthalten in: |
Biomarkers in medicine - 17(2023), 3 vom: 27. Feb., Seite 133-142 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Zhang, Chunlin [VerfasserIn] |
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| Links: |
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| Anmerkungen: |
Date Completed 28.04.2023 Date Revised 30.05.2023 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.2217/bmm-2022-0702 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM356006956 |
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| 100 | 1 | |a Zhang, Chunlin |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Association of TLR4 and TLR9 gene polymorphisms with the risk and progression of cervical lesions in HPV-infected women |
| 264 | 1 | |c 2023 | |
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| 500 | |a Date Completed 28.04.2023 | ||
| 500 | |a Date Revised 30.05.2023 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a Aim: Toll-like receptors involved in tumor-associated inflammatory response, this study aimed to investigate the role of TLR4 and TLR9 gene polymorphisms in the risk and progression of HPV-related cervical lesions. Materials & methods: A total of 220 cervical lesion patients and 227 healthy controls were enrolled. Single-nucleotide polymorphisms were genotyped using PCR-restriction fragment length polymorphism. Results: A significantly decreased risk of cervical lesions was observed to be associated with the TLR4 rs10116253 (C), rs1927911 (T) and rs10759931 (G) mutant alleles. rs187084-rs1927911-HPV-16/18 was the best interaction model to affect cervical lesion risk. Conclusion: TLR4 rs10116253, rs1927911 and rs10759931 were potential biomarkers for cervical lesion susceptibility | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Research Support, Non-U.S. Gov't | |
| 650 | 4 | |a HPV | |
| 650 | 4 | |a Toll-like receptors | |
| 650 | 4 | |a cervical lesions | |
| 650 | 4 | |a single-nucleotide polymorphisms | |
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| 650 | 7 | |a Toll-Like Receptor 9 |2 NLM | |
| 650 | 7 | |a TLR9 protein, human |2 NLM | |
| 650 | 7 | |a TLR4 protein, human |2 NLM | |
| 700 | 1 | |a Yang, Zhiping |e verfasserin |4 aut | |
| 700 | 1 | |a Luo, Ping |e verfasserin |4 aut | |
| 700 | 1 | |a Ye, Mengxia |e verfasserin |4 aut | |
| 700 | 1 | |a Gong, Ping |e verfasserin |4 aut | |
| 700 | 1 | |a Gong, Quan |e verfasserin |4 aut | |
| 700 | 1 | |a Mei, Bing |e verfasserin |4 aut | |
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