SARS-CoV-2 variants and mutational patterns : relationship with risk of ventilator-associated pneumonia in critically ill COVID-19 patients in the era of dexamethasone
© 2023. The Author(s)..
We aimed to explore the relationships between specific viral mutations/mutational patterns and ventilator-associated pneumonia (VAP) occurrence in COVID-19 patients admitted in intensive care units between October 1, 2020, and May 30, 2021. Full-length SARS-CoV-2 genomes were sequenced by means of next-generation sequencing. In this prospective multicentre cohort study, 259 patients were included. 222 patients (47%) had been infected with pre-existing ancestral variants, 116 (45%) with variant α, and 21 (8%) with other variants. 153 patients (59%) developed at least one VAP. There was no significant relationship between VAP occurrence and a specific SARS CoV-2 lineage/sublineage or mutational pattern.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2023 |
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| Erschienen: |
2023 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:13 |
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| Enthalten in: |
Scientific reports - 13(2023), 1 vom: 24. Apr., Seite 6658 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Razazi, Keyvan [VerfasserIn] |
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| Links: |
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| Themen: |
7S5I7G3JQL |
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| Anmerkungen: |
Date Completed 26.04.2023 Date Revised 10.05.2023 published: Electronic Citation Status MEDLINE |
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| doi: |
10.1038/s41598-023-33639-5 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM355988224 |
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| 520 | |a © 2023. The Author(s). | ||
| 520 | |a We aimed to explore the relationships between specific viral mutations/mutational patterns and ventilator-associated pneumonia (VAP) occurrence in COVID-19 patients admitted in intensive care units between October 1, 2020, and May 30, 2021. Full-length SARS-CoV-2 genomes were sequenced by means of next-generation sequencing. In this prospective multicentre cohort study, 259 patients were included. 222 patients (47%) had been infected with pre-existing ancestral variants, 116 (45%) with variant α, and 21 (8%) with other variants. 153 patients (59%) developed at least one VAP. There was no significant relationship between VAP occurrence and a specific SARS CoV-2 lineage/sublineage or mutational pattern | ||
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| 700 | 1 | |a Peiffer, Bastien |e verfasserin |4 aut | |
| 700 | 1 | |a Voiriot, Guillaume |e verfasserin |4 aut | |
| 700 | 1 | |a Luyt, Charles-Edouard |e verfasserin |4 aut | |
| 700 | 1 | |a Urbina, Tomas |e verfasserin |4 aut | |
| 700 | 1 | |a Mayaux, Julien |e verfasserin |4 aut | |
| 700 | 1 | |a Pham, Tài |e verfasserin |4 aut | |
| 700 | 1 | |a Roux, Damien |e verfasserin |4 aut | |
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| 700 | 1 | |a Rodriguez, Christophe |e verfasserin |4 aut | |
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| 700 | 1 | |a Fourati, Slim |e verfasserin |4 aut | |
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