Effect of High-Intensity Statin Therapy on Atherosclerosis (IBIS-4) : Manual Versus Automated Methods of IVUS Analysis
Copyright © 2023 Elsevier Inc. All rights reserved..
AIMS: Standard manual analysis of IVUS to study the impact of anti-atherosclerotic therapies on the coronary vessel wall is done by a core laboratory (CL), the ground truth (GT). Automatic segmentation of IVUS with a machine learning (ML) algorithm has the potential to replace manual readings with an unbiased and reproducible method. The aim is to determine if results from a CL can be replicated with ML methods.
METHODS: This is a post-hoc, comparative analysis of the IBIS-4 (Integrated Biomarkers and Imaging Study-4) study (NCT00962416). The GT baseline and 13-month follow-up measurements of lumen and vessel area and percent atheroma volume (PAV) after statin induction were repeated by the ML algorithm.
RESULTS: The primary endpoint was change in PAV. PAV as measured by GT was 43.95 % at baseline and 43.02 % at follow-up with a change of -0.90 % (p = 0.007) while the ML algorithm measured 43.69 % and 42.41 % for baseline and follow-up, respectively, with a change of -1.28 % (p < 0.001). Along the most diseased 10 mm segments, GT-PAV was 52.31 % at baseline and 49.42 % at follow-up, with a change of -2.94 % (p < 0.001). The same segments measured by the ML algorithm resulted in PAV of 51.55 % at baseline and 47.81 % at follow-up with a change of -3.74 % (p < 0.001).
CONCLUSIONS: PAV, the most used endpoint in clinical trials, analyzed by the CL is closely replicated by the ML algorithm. ML automatic segmentation of lumen, vessel and plaque effectively reproduces GT and may be used in future clinical trials as the standard.
| Errataetall: |
CommentIn: Cardiovasc Revasc Med. 2023 Sep;54:39-40. - PMID 37302953 |
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| Medienart: |
E-Artikel |
| Erscheinungsjahr: |
2023 |
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| Erschienen: |
2023 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:54 |
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| Enthalten in: |
Cardiovascular revascularization medicine : including molecular interventions - 54(2023) vom: 01. Sept., Seite 33-38 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Bass, Ronald D [VerfasserIn] |
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| Links: |
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| Themen: |
Comparative Study |
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| Anmerkungen: |
Date Completed 25.10.2023 Date Revised 25.10.2023 published: Print-Electronic ClinicalTrials.gov: NCT00962416 CommentIn: Cardiovasc Revasc Med. 2023 Sep;54:39-40. - PMID 37302953 Citation Status MEDLINE |
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| doi: |
10.1016/j.carrev.2023.04.007 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| 100 | 1 | |a Bass, Ronald D |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Effect of High-Intensity Statin Therapy on Atherosclerosis (IBIS-4) |b Manual Versus Automated Methods of IVUS Analysis |
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| 500 | |a Date Completed 25.10.2023 | ||
| 500 | |a Date Revised 25.10.2023 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a ClinicalTrials.gov: NCT00962416 | ||
| 500 | |a CommentIn: Cardiovasc Revasc Med. 2023 Sep;54:39-40. - PMID 37302953 | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a Copyright © 2023 Elsevier Inc. All rights reserved. | ||
| 520 | |a AIMS: Standard manual analysis of IVUS to study the impact of anti-atherosclerotic therapies on the coronary vessel wall is done by a core laboratory (CL), the ground truth (GT). Automatic segmentation of IVUS with a machine learning (ML) algorithm has the potential to replace manual readings with an unbiased and reproducible method. The aim is to determine if results from a CL can be replicated with ML methods | ||
| 520 | |a METHODS: This is a post-hoc, comparative analysis of the IBIS-4 (Integrated Biomarkers and Imaging Study-4) study (NCT00962416). The GT baseline and 13-month follow-up measurements of lumen and vessel area and percent atheroma volume (PAV) after statin induction were repeated by the ML algorithm | ||
| 520 | |a RESULTS: The primary endpoint was change in PAV. PAV as measured by GT was 43.95 % at baseline and 43.02 % at follow-up with a change of -0.90 % (p = 0.007) while the ML algorithm measured 43.69 % and 42.41 % for baseline and follow-up, respectively, with a change of -1.28 % (p < 0.001). Along the most diseased 10 mm segments, GT-PAV was 52.31 % at baseline and 49.42 % at follow-up, with a change of -2.94 % (p < 0.001). The same segments measured by the ML algorithm resulted in PAV of 51.55 % at baseline and 47.81 % at follow-up with a change of -3.74 % (p < 0.001) | ||
| 520 | |a CONCLUSIONS: PAV, the most used endpoint in clinical trials, analyzed by the CL is closely replicated by the ML algorithm. ML automatic segmentation of lumen, vessel and plaque effectively reproduces GT and may be used in future clinical trials as the standard | ||
| 650 | 4 | |a Comparative Study | |
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Coronary artery disease | |
| 650 | 4 | |a Intravascular ultrasound | |
| 650 | 4 | |a Lumen segmentation | |
| 650 | 4 | |a Machine learning | |
| 650 | 4 | |a Vessel segmentation | |
| 650 | 7 | |a Hydroxymethylglutaryl-CoA Reductase Inhibitors |2 NLM | |
| 700 | 1 | |a García-García, Héctor M |e verfasserin |4 aut | |
| 700 | 1 | |a Ueki, Yasushi |e verfasserin |4 aut | |
| 700 | 1 | |a Holmvang, Lene |e verfasserin |4 aut | |
| 700 | 1 | |a Pedrazzini, Giovanni |e verfasserin |4 aut | |
| 700 | 1 | |a Roffi, Marco |e verfasserin |4 aut | |
| 700 | 1 | |a Koskinas, Konstantinos C |e verfasserin |4 aut | |
| 700 | 1 | |a Shibutani, Hiroki |e verfasserin |4 aut | |
| 700 | 1 | |a Losdat, Sylvain |e verfasserin |4 aut | |
| 700 | 1 | |a Ziemer, Paulo G P |e verfasserin |4 aut | |
| 700 | 1 | |a Blanco, Pablo J |e verfasserin |4 aut | |
| 700 | 1 | |a Levine, Molly B |e verfasserin |4 aut | |
| 700 | 1 | |a Bourantas, Christos V |e verfasserin |4 aut | |
| 700 | 1 | |a Räber, Lorenz |e verfasserin |4 aut | |
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