Biological age is increased by stress and restored upon recovery
Copyright © 2023 Elsevier Inc. All rights reserved..
Aging is classically conceptualized as an ever-increasing trajectory of damage accumulation and loss of function, leading to increases in morbidity and mortality. However, recent in vitro studies have raised the possibility of age reversal. Here, we report that biological age is fluid and exhibits rapid changes in both directions. At epigenetic, transcriptomic, and metabolomic levels, we find that the biological age of young mice is increased by heterochronic parabiosis and restored following surgical detachment. We also identify transient changes in biological age during major surgery, pregnancy, and severe COVID-19 in humans and/or mice. Together, these data show that biological age undergoes a rapid increase in response to diverse forms of stress, which is reversed following recovery from stress. Our study uncovers a new layer of aging dynamics that should be considered in future studies. The elevation of biological age by stress may be a quantifiable and actionable target for future interventions.
| Medienart: |
E-Artikel |
|---|
| Erscheinungsjahr: |
2023 |
|---|---|
| Erschienen: |
2023 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:35 |
|---|---|
| Enthalten in: |
Cell metabolism - 35(2023), 5 vom: 02. Mai, Seite 807-820.e5 |
| Sprache: |
Englisch |
|---|
| Beteiligte Personen: |
Poganik, Jesse R [VerfasserIn] |
|---|
| Links: |
|---|
| Themen: |
Aging |
|---|
| Anmerkungen: |
Date Completed 05.05.2023 Date Revised 28.04.2024 published: Print-Electronic Citation Status MEDLINE |
|---|
| doi: |
10.1016/j.cmet.2023.03.015 |
|---|
| funding: |
|
|---|---|
| Förderinstitution / Projekttitel: |
|
| PPN (Katalog-ID): |
NLM355904497 |
|---|
| LEADER | 01000caa a22002652 4500 | ||
|---|---|---|---|
| 001 | NLM355904497 | ||
| 003 | DE-627 | ||
| 005 | 20240428231844.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 231226s2023 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1016/j.cmet.2023.03.015 |2 doi | |
| 028 | 5 | 2 | |a pubmed24n1391.xml |
| 035 | |a (DE-627)NLM355904497 | ||
| 035 | |a (NLM)37086720 | ||
| 035 | |a (PII)S1550-4131(23)00093-1 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
| 041 | |a eng | ||
| 100 | 1 | |a Poganik, Jesse R |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Biological age is increased by stress and restored upon recovery |
| 264 | 1 | |c 2023 | |
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a ƒaComputermedien |b c |2 rdamedia | ||
| 338 | |a ƒa Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Date Completed 05.05.2023 | ||
| 500 | |a Date Revised 28.04.2024 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a Copyright © 2023 Elsevier Inc. All rights reserved. | ||
| 520 | |a Aging is classically conceptualized as an ever-increasing trajectory of damage accumulation and loss of function, leading to increases in morbidity and mortality. However, recent in vitro studies have raised the possibility of age reversal. Here, we report that biological age is fluid and exhibits rapid changes in both directions. At epigenetic, transcriptomic, and metabolomic levels, we find that the biological age of young mice is increased by heterochronic parabiosis and restored following surgical detachment. We also identify transient changes in biological age during major surgery, pregnancy, and severe COVID-19 in humans and/or mice. Together, these data show that biological age undergoes a rapid increase in response to diverse forms of stress, which is reversed following recovery from stress. Our study uncovers a new layer of aging dynamics that should be considered in future studies. The elevation of biological age by stress may be a quantifiable and actionable target for future interventions | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Research Support, N.I.H., Extramural | |
| 650 | 4 | |a Research Support, Non-U.S. Gov't | |
| 650 | 4 | |a aging | |
| 650 | 4 | |a biological age | |
| 650 | 4 | |a dynamics | |
| 650 | 4 | |a epigenetic aging clocks | |
| 650 | 4 | |a recovery | |
| 650 | 4 | |a stress | |
| 700 | 1 | |a Zhang, Bohan |e verfasserin |4 aut | |
| 700 | 1 | |a Baht, Gurpreet S |e verfasserin |4 aut | |
| 700 | 1 | |a Tyshkovskiy, Alexander |e verfasserin |4 aut | |
| 700 | 1 | |a Deik, Amy |e verfasserin |4 aut | |
| 700 | 1 | |a Kerepesi, Csaba |e verfasserin |4 aut | |
| 700 | 1 | |a Yim, Sun Hee |e verfasserin |4 aut | |
| 700 | 1 | |a Lu, Ake T |e verfasserin |4 aut | |
| 700 | 1 | |a Haghani, Amin |e verfasserin |4 aut | |
| 700 | 1 | |a Gong, Tong |e verfasserin |4 aut | |
| 700 | 1 | |a Hedman, Anna M |e verfasserin |4 aut | |
| 700 | 1 | |a Andolf, Ellika |e verfasserin |4 aut | |
| 700 | 1 | |a Pershagen, Göran |e verfasserin |4 aut | |
| 700 | 1 | |a Almqvist, Catarina |e verfasserin |4 aut | |
| 700 | 1 | |a Clish, Clary B |e verfasserin |4 aut | |
| 700 | 1 | |a Horvath, Steve |e verfasserin |4 aut | |
| 700 | 1 | |a White, James P |e verfasserin |4 aut | |
| 700 | 1 | |a Gladyshev, Vadim N |e verfasserin |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Cell metabolism |d 2005 |g 35(2023), 5 vom: 02. Mai, Seite 807-820.e5 |w (DE-627)NLM156885433 |x 1932-7420 |7 nnns |
| 773 | 1 | 8 | |g volume:35 |g year:2023 |g number:5 |g day:02 |g month:05 |g pages:807-820.e5 |
| 856 | 4 | 0 | |u http://dx.doi.org/10.1016/j.cmet.2023.03.015 |3 Volltext |
| 912 | |a GBV_USEFLAG_A | ||
| 912 | |a GBV_NLM | ||
| 951 | |a AR | ||
| 952 | |d 35 |j 2023 |e 5 |b 02 |c 05 |h 807-820.e5 | ||