Gastrectomy reduces pancreatic secretory function via pancreatic atrophy
© 2023. The Author(s)..
PURPOSE: Although reports suggest that the pancreatic volume decreases after gastrectomy for gastric cancer, the relationship between the pancreatic volume and secretory function after gastrectomy remains unclear. In this study, we examined the relationship between the pancreatic volume and exocrine and endocrine functions after total gastrectomy.
METHODS: The pancreatic volumes of 18 distal gastrectomy and 15 total gastrectomy patients were retrospectively measured using computed tomography volumetry up to 5 years postoperatively. Ten low anterior resection patients were selected as controls. In addition, the pancreatic volume and exocrine function evaluated by fecal elastase and the insulin secretory function evaluated by glucagon tolerance testing were prospectively examined before and one year after surgery in nine cases of total gastrectomy.
RESULTS: After low anterior resection, the pancreatic volume did not change, but after distal and total gastrectomy, the pancreatic volume decreased continuously until the fifth year. After total gastrectomy, fecal elastase decreased significantly from 865.8 μg/g to 603.2 μg/g in the first year (p = 0.0316), and the insulin secretion capacity also decreased significantly from 3.83 ng/mL to 2.26 ng/mL (p = 0.0019).
CONCLUSIONS: The pancreatic volume decreases continuously after gastrectomy for gastric cancer, and the pancreatic exocrine and endocrine functions decrease along with pancreatic atrophy after total gastrectomy.
| Medienart: |
E-Artikel |
|---|
| Erscheinungsjahr: |
2023 |
|---|---|
| Erschienen: |
2023 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:53 |
|---|---|
| Enthalten in: |
Surgery today - 53(2023), 12 vom: 21. Dez., Seite 1372-1379 |
| Sprache: |
Englisch |
|---|
| Beteiligte Personen: |
Satoi, Shumpei [VerfasserIn] |
|---|
| Links: |
|---|
| Themen: |
EC 3.4.21.36 |
|---|
| Anmerkungen: |
Date Completed 05.12.2023 Date Revised 05.12.2023 published: Print-Electronic Citation Status MEDLINE |
|---|
| doi: |
10.1007/s00595-023-02685-x |
|---|
| funding: |
|
|---|---|
| Förderinstitution / Projekttitel: |
|
| PPN (Katalog-ID): |
NLM355878658 |
|---|
| LEADER | 01000naa a22002652 4500 | ||
|---|---|---|---|
| 001 | NLM355878658 | ||
| 003 | DE-627 | ||
| 005 | 20231226065258.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 231226s2023 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1007/s00595-023-02685-x |2 doi | |
| 028 | 5 | 2 | |a pubmed24n1186.xml |
| 035 | |a (DE-627)NLM355878658 | ||
| 035 | |a (NLM)37084095 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
| 041 | |a eng | ||
| 100 | 1 | |a Satoi, Shumpei |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Gastrectomy reduces pancreatic secretory function via pancreatic atrophy |
| 264 | 1 | |c 2023 | |
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a ƒaComputermedien |b c |2 rdamedia | ||
| 338 | |a ƒa Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Date Completed 05.12.2023 | ||
| 500 | |a Date Revised 05.12.2023 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a © 2023. The Author(s). | ||
| 520 | |a PURPOSE: Although reports suggest that the pancreatic volume decreases after gastrectomy for gastric cancer, the relationship between the pancreatic volume and secretory function after gastrectomy remains unclear. In this study, we examined the relationship between the pancreatic volume and exocrine and endocrine functions after total gastrectomy | ||
| 520 | |a METHODS: The pancreatic volumes of 18 distal gastrectomy and 15 total gastrectomy patients were retrospectively measured using computed tomography volumetry up to 5 years postoperatively. Ten low anterior resection patients were selected as controls. In addition, the pancreatic volume and exocrine function evaluated by fecal elastase and the insulin secretory function evaluated by glucagon tolerance testing were prospectively examined before and one year after surgery in nine cases of total gastrectomy | ||
| 520 | |a RESULTS: After low anterior resection, the pancreatic volume did not change, but after distal and total gastrectomy, the pancreatic volume decreased continuously until the fifth year. After total gastrectomy, fecal elastase decreased significantly from 865.8 μg/g to 603.2 μg/g in the first year (p = 0.0316), and the insulin secretion capacity also decreased significantly from 3.83 ng/mL to 2.26 ng/mL (p = 0.0019) | ||
| 520 | |a CONCLUSIONS: The pancreatic volume decreases continuously after gastrectomy for gastric cancer, and the pancreatic exocrine and endocrine functions decrease along with pancreatic atrophy after total gastrectomy | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Gastrectomy | |
| 650 | 4 | |a Pancreatic function | |
| 650 | 4 | |a Pancreatic volume | |
| 650 | 7 | |a Pancreatic Elastase |2 NLM | |
| 650 | 7 | |a EC 3.4.21.36 |2 NLM | |
| 700 | 1 | |a Kimura, Yutaka |e verfasserin |4 aut | |
| 700 | 1 | |a Shimizu, Rie |e verfasserin |4 aut | |
| 700 | 1 | |a Matsumoto, Masataka |e verfasserin |4 aut | |
| 700 | 1 | |a Kawaguchi, Kohei |e verfasserin |4 aut | |
| 700 | 1 | |a Yoshida, Yuta |e verfasserin |4 aut | |
| 700 | 1 | |a Murase, Takaaki |e verfasserin |4 aut | |
| 700 | 1 | |a Kamei, Keiko |e verfasserin |4 aut | |
| 700 | 1 | |a Matsumoto, Ippei |e verfasserin |4 aut | |
| 700 | 1 | |a Nakai, Takuya |e verfasserin |4 aut | |
| 700 | 1 | |a Takeyama, Yoshifumi |e verfasserin |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Surgery today |d 1997 |g 53(2023), 12 vom: 21. Dez., Seite 1372-1379 |w (DE-627)NLM012623938 |x 1436-2813 |7 nnns |
| 773 | 1 | 8 | |g volume:53 |g year:2023 |g number:12 |g day:21 |g month:12 |g pages:1372-1379 |
| 856 | 4 | 0 | |u http://dx.doi.org/10.1007/s00595-023-02685-x |3 Volltext |
| 912 | |a GBV_USEFLAG_A | ||
| 912 | |a GBV_NLM | ||
| 951 | |a AR | ||
| 952 | |d 53 |j 2023 |e 12 |b 21 |c 12 |h 1372-1379 | ||