Molecular Engineering of pH-Responsive Anchoring Systems onto Poly(ethylene glycol) Corona
An adaptive surface that can sense and respond to environmental stimuli is integral to smart functional materials. Here, we report pH-responsive anchoring systems onto the poly(ethylene glycol) (PEG) corona of polymer vesicles. The hydrophobic anchor, pyrene, is reversibly inserted into the PEG corona through the reversible protonation of its covalently linked pH-sensing group. Depending on the pKa of the sensor, the pH-responsive region is engineered from acidic to neutral and basic conditions. The switchable electrostatic repulsion between the sensors contributes to the responsive anchoring behavior. Our findings provide a new responsive binding chemistry for the creation of smart nanomedicine and a nanoreactor.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2023 |
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| Erschienen: |
2023 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:145 |
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| Enthalten in: |
Journal of the American Chemical Society - 145(2023), 19 vom: 17. Mai, Seite 10458-10462 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Zhang, Shaohua [VerfasserIn] |
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| Links: |
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| Anmerkungen: |
Date Completed 17.05.2023 Date Revised 22.05.2023 published: Print-Electronic Citation Status PubMed-not-MEDLINE |
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| doi: |
10.1021/jacs.3c00986 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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NLM355785323 |
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| 520 | |a An adaptive surface that can sense and respond to environmental stimuli is integral to smart functional materials. Here, we report pH-responsive anchoring systems onto the poly(ethylene glycol) (PEG) corona of polymer vesicles. The hydrophobic anchor, pyrene, is reversibly inserted into the PEG corona through the reversible protonation of its covalently linked pH-sensing group. Depending on the pKa of the sensor, the pH-responsive region is engineered from acidic to neutral and basic conditions. The switchable electrostatic repulsion between the sensors contributes to the responsive anchoring behavior. Our findings provide a new responsive binding chemistry for the creation of smart nanomedicine and a nanoreactor | ||
| 650 | 4 | |a Journal Article | |
| 700 | 1 | |a Srivastava, Abhinav |e verfasserin |4 aut | |
| 700 | 1 | |a Li, Wei |e verfasserin |4 aut | |
| 700 | 1 | |a Rijpkema, Sjoerd J |e verfasserin |4 aut | |
| 700 | 1 | |a Carnevale, Vincenzo |e verfasserin |4 aut | |
| 700 | 1 | |a Klein, Michael L |e verfasserin |4 aut | |
| 700 | 1 | |a Wilson, Daniela A |e verfasserin |4 aut | |
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