High adherence to Western dietary pattern and prostate cancer risk : findings from the EPIC-Spain cohort
© 2023 BJU International..
OBJECTIVE: To explore the association between three previously identified dietary patterns (Western, Prudent and Mediterranean) and prostate cancer (PCa) risk by tumour aggressiveness.
SUBJECTS AND METHODS: The Spanish cohort of the European Prospective Investigation into Cancer and Nutrition study provided dietary and epidemiological information from 15 296 men recruited during the period 1992-1996. The associations between the adherence to the three dietary patterns and PCa risk (global, for Gleason grade groups 6 and >6, and for International Society of Urological Pathology [ISUP] grade 1 + 2 and ISUP grade 3 + 4 + 5) was explored with multivariable Cox proportional hazards regression models stratified by centre and age.
RESULTS: While no effect on PCa risk was detected for the Prudent and Mediterranean dietary patterns, a suggestion of a detrimental effect of the Western dietary pattern was found (hazard ratio [HR]Q4vsQ1 1.29 [95% confidence interval {CI} 0.96;1.72]). This effect was only observed for Gleason grade group >6 (HRQ3vsQ1 1.61 [95% CI 1.00; 2.59] and HRQ4vsQ1 1.60 [95% CI 0.96; 2.67]) and in particular ISUP grade 3 + 4 + 5 tumours (HRQ2vsQ1 1.97 [95% CI 0.98; 3.93]; HRQ3vsQ1 2.72 (95% CI 1.35; 5.51); HRQ4vsQ1 2.29 [95% CI 1.07; 4.92]).
CONCLUSIONS: Our results suggest that a high adherence to a healthy diet such as that represented by the Prudent and Mediterranean dietary patterns is not enough to prevent prostate cancer. Additionally, reducing adherence to a Western-type diet seems to be necessary.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2023 |
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| Erschienen: |
2023 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:132 |
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| Enthalten in: |
BJU international - 132(2023), 3 vom: 19. Sept., Seite 272-282 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Castelló, Adela [VerfasserIn] |
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| Links: |
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| Themen: |
#PCSM |
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| Anmerkungen: |
Date Completed 16.08.2023 Date Revised 16.08.2023 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1111/bju.16001 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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NLM355774712 |
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| 100 | 1 | |a Castelló, Adela |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a High adherence to Western dietary pattern and prostate cancer risk |b findings from the EPIC-Spain cohort |
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| 500 | |a Date Revised 16.08.2023 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a © 2023 BJU International. | ||
| 520 | |a OBJECTIVE: To explore the association between three previously identified dietary patterns (Western, Prudent and Mediterranean) and prostate cancer (PCa) risk by tumour aggressiveness | ||
| 520 | |a SUBJECTS AND METHODS: The Spanish cohort of the European Prospective Investigation into Cancer and Nutrition study provided dietary and epidemiological information from 15 296 men recruited during the period 1992-1996. The associations between the adherence to the three dietary patterns and PCa risk (global, for Gleason grade groups 6 and >6, and for International Society of Urological Pathology [ISUP] grade 1 + 2 and ISUP grade 3 + 4 + 5) was explored with multivariable Cox proportional hazards regression models stratified by centre and age | ||
| 520 | |a RESULTS: While no effect on PCa risk was detected for the Prudent and Mediterranean dietary patterns, a suggestion of a detrimental effect of the Western dietary pattern was found (hazard ratio [HR]Q4vsQ1 1.29 [95% confidence interval {CI} 0.96;1.72]). This effect was only observed for Gleason grade group >6 (HRQ3vsQ1 1.61 [95% CI 1.00; 2.59] and HRQ4vsQ1 1.60 [95% CI 0.96; 2.67]) and in particular ISUP grade 3 + 4 + 5 tumours (HRQ2vsQ1 1.97 [95% CI 0.98; 3.93]; HRQ3vsQ1 2.72 (95% CI 1.35; 5.51); HRQ4vsQ1 2.29 [95% CI 1.07; 4.92]) | ||
| 520 | |a CONCLUSIONS: Our results suggest that a high adherence to a healthy diet such as that represented by the Prudent and Mediterranean dietary patterns is not enough to prevent prostate cancer. Additionally, reducing adherence to a Western-type diet seems to be necessary | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Research Support, Non-U.S. Gov't | |
| 650 | 4 | |a #PCSM | |
| 650 | 4 | |a #ProstateCancer | |
| 650 | 4 | |a #uroonc | |
| 650 | 4 | |a EPIC-Spain | |
| 650 | 4 | |a Mediterranean | |
| 650 | 4 | |a cancer | |
| 650 | 4 | |a diet | |
| 650 | 4 | |a dietary patterns | |
| 650 | 4 | |a prostate neoplasms | |
| 700 | 1 | |a Rodríguez-Barranco, Miguel |e verfasserin |4 aut | |
| 700 | 1 | |a Pérez-Gómez, Beatriz |e verfasserin |4 aut | |
| 700 | 1 | |a Chirlaque, Maria Dolores |e verfasserin |4 aut | |
| 700 | 1 | |a Bonet, Catalina |e verfasserin |4 aut | |
| 700 | 1 | |a Amiano, Pilar |e verfasserin |4 aut | |
| 700 | 1 | |a Ardanaz, Eva |e verfasserin |4 aut | |
| 700 | 1 | |a Huerta, José María |e verfasserin |4 aut | |
| 700 | 1 | |a Zamora-Ros, Raúl |e verfasserin |4 aut | |
| 700 | 1 | |a Quirós, José Ramon |e verfasserin |4 aut | |
| 700 | 1 | |a Barricarte-Gurrea, Aurelio |e verfasserin |4 aut | |
| 700 | 1 | |a Pollán, Marina |e verfasserin |4 aut | |
| 700 | 1 | |a Sanchez, María-José |e verfasserin |4 aut | |
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