A Phenome-Wide Association Study (PheWAS) of Late Onset Alzheimer Disease Genetic Risk in Children of European Ancestry at Middle Childhood : Results from the ABCD Study
© 2023. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature..
Genetic risk for Late Onset Alzheimer Disease (AD) has been associated with lower cognition and smaller hippocampal volume in healthy young adults. However, whether these and other associations are present during childhood remains unclear. Using data from 5556 genomically-confirmed European ancestry youth who completed the baseline session of the ongoing the Adolescent Brain Cognitive DevelopmentSM Study (ABCD Study®), our phenome-wide association study estimating associations between four indices of genetic risk for late-onset AD (i.e., AD polygenic risk scores (PRS), APOE rs429358 genotype, AD PRS with the APOE region removed (ADPRS-APOE), and an interaction between ADPRS-APOE and APOE genotype) and 1687 psychosocial, behavioral, and neural phenotypes revealed no significant associations after correction for multiple testing (all ps > 0.0002; all pfdr > 0.07). These data suggest that AD genetic risk may not phenotypically manifest during middle-childhood or that effects are smaller than this sample is powered to detect.
Medienart: |
E-Artikel |
---|
Erscheinungsjahr: |
2023 |
---|---|
Erschienen: |
2023 |
Enthalten in: |
Zur Gesamtaufnahme - volume:53 |
---|---|
Enthalten in: |
Behavior genetics - 53(2023), 3 vom: 18. Mai, Seite 249-264 |
Sprache: |
Englisch |
---|
Beteiligte Personen: |
Gorelik, Aaron J [VerfasserIn] |
---|
Links: |
---|
Anmerkungen: |
Date Completed 04.05.2023 Date Revised 02.07.2023 published: Print-Electronic Citation Status MEDLINE |
---|
doi: |
10.1007/s10519-023-10140-3 |
---|
funding: |
|
---|---|
Förderinstitution / Projekttitel: |
|
PPN (Katalog-ID): |
NLM355751763 |
---|
LEADER | 01000naa a22002652 4500 | ||
---|---|---|---|
001 | NLM355751763 | ||
003 | DE-627 | ||
005 | 20231226065015.0 | ||
007 | cr uuu---uuuuu | ||
008 | 231226s2023 xx |||||o 00| ||eng c | ||
024 | 7 | |a 10.1007/s10519-023-10140-3 |2 doi | |
028 | 5 | 2 | |a pubmed24n1185.xml |
035 | |a (DE-627)NLM355751763 | ||
035 | |a (NLM)37071275 | ||
040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
041 | |a eng | ||
100 | 1 | |a Gorelik, Aaron J |e verfasserin |4 aut | |
245 | 1 | 2 | |a A Phenome-Wide Association Study (PheWAS) of Late Onset Alzheimer Disease Genetic Risk in Children of European Ancestry at Middle Childhood |b Results from the ABCD Study |
264 | 1 | |c 2023 | |
336 | |a Text |b txt |2 rdacontent | ||
337 | |a ƒaComputermedien |b c |2 rdamedia | ||
338 | |a ƒa Online-Ressource |b cr |2 rdacarrier | ||
500 | |a Date Completed 04.05.2023 | ||
500 | |a Date Revised 02.07.2023 | ||
500 | |a published: Print-Electronic | ||
500 | |a Citation Status MEDLINE | ||
520 | |a © 2023. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature. | ||
520 | |a Genetic risk for Late Onset Alzheimer Disease (AD) has been associated with lower cognition and smaller hippocampal volume in healthy young adults. However, whether these and other associations are present during childhood remains unclear. Using data from 5556 genomically-confirmed European ancestry youth who completed the baseline session of the ongoing the Adolescent Brain Cognitive DevelopmentSM Study (ABCD Study®), our phenome-wide association study estimating associations between four indices of genetic risk for late-onset AD (i.e., AD polygenic risk scores (PRS), APOE rs429358 genotype, AD PRS with the APOE region removed (ADPRS-APOE), and an interaction between ADPRS-APOE and APOE genotype) and 1687 psychosocial, behavioral, and neural phenotypes revealed no significant associations after correction for multiple testing (all ps > 0.0002; all pfdr > 0.07). These data suggest that AD genetic risk may not phenotypically manifest during middle-childhood or that effects are smaller than this sample is powered to detect | ||
650 | 4 | |a Journal Article | |
650 | 4 | |a Research Support, N.I.H., Extramural | |
650 | 4 | |a Research Support, U.S. Gov't, Non-P.H.S. | |
650 | 4 | |a APOE | |
650 | 4 | |a Alzheimer disease | |
650 | 4 | |a Imaging | |
650 | 4 | |a Middle childhood | |
650 | 4 | |a Phenome-wide association study | |
650 | 4 | |a Polygenic risk scores | |
650 | 7 | |a Apolipoproteins E |2 NLM | |
700 | 1 | |a Paul, Sarah E |e verfasserin |4 aut | |
700 | 1 | |a Karcher, Nicole R |e verfasserin |4 aut | |
700 | 1 | |a Johnson, Emma C |e verfasserin |4 aut | |
700 | 1 | |a Nagella, Isha |e verfasserin |4 aut | |
700 | 1 | |a Blaydon, Lauren |e verfasserin |4 aut | |
700 | 1 | |a Modi, Hailey |e verfasserin |4 aut | |
700 | 1 | |a Hansen, Isabella S |e verfasserin |4 aut | |
700 | 1 | |a Colbert, Sarah M C |e verfasserin |4 aut | |
700 | 1 | |a Baranger, David A A |e verfasserin |4 aut | |
700 | 1 | |a Norton, Sara A |e verfasserin |4 aut | |
700 | 1 | |a Spears, Isaiah |e verfasserin |4 aut | |
700 | 1 | |a Gordon, Brian |e verfasserin |4 aut | |
700 | 1 | |a Zhang, Wei |e verfasserin |4 aut | |
700 | 1 | |a Hill, Patrick L |e verfasserin |4 aut | |
700 | 1 | |a Oltmanns, Thomas F |e verfasserin |4 aut | |
700 | 1 | |a Bijsterbosch, Janine D |e verfasserin |4 aut | |
700 | 1 | |a Agrawal, Arpana |e verfasserin |4 aut | |
700 | 1 | |a Hatoum, Alexander S |e verfasserin |4 aut | |
700 | 1 | |a Bogdan, Ryan |e verfasserin |4 aut | |
773 | 0 | 8 | |i Enthalten in |t Behavior genetics |d 1970 |g 53(2023), 3 vom: 18. Mai, Seite 249-264 |w (DE-627)NLM000329533 |x 1573-3297 |7 nnns |
773 | 1 | 8 | |g volume:53 |g year:2023 |g number:3 |g day:18 |g month:05 |g pages:249-264 |
856 | 4 | 0 | |u http://dx.doi.org/10.1007/s10519-023-10140-3 |3 Volltext |
912 | |a GBV_USEFLAG_A | ||
912 | |a GBV_NLM | ||
951 | |a AR | ||
952 | |d 53 |j 2023 |e 3 |b 18 |c 05 |h 249-264 |