Wnt/β-catenin Signaling in Lung Cancer : Association with Proliferation, Metastasis, and Therapy Resistance
Copyright© Bentham Science Publishers; For any queries, please email at epubbenthamscience.net..
The capacity of cancer cells for abnormal growth and metastasis has made it difficult to find a cure for tumor. Both males and females suffer from lung tumors, and physicians still deem them incurable. The initiation and development of lung tumors can be forced by genomic mutations. Wnt is a critical pathway for regulating growth, differentiation and migration. However, its oncogenic function has been observed in lung cancer. Wnt is able to increase the proliferation of lung tumors. The metastasis potential of lung tumors can be accelerated by Wnt/EMT axis. Overexpression of Wnt/β-catenin prevents chemotherapy-mediated cell death in lung tumors. This pathway promotes cancer stem cell features in lung tumors which induce radioresistance. Anti-cancer agents, such as curcumin, are able to inhibit Wnt in lung tumor treatment. Wnt interaction with other factors in lung tumors is essential in controlling biological behavior, and non-coding RNA transcripts are the most well-known ones. It can be concluded from the current study that Wnt is an important regulator of lung tumorigenesis, and the translation of these findings into the clinic is vital.
| Medienart: |
E-Artikel |
|---|
| Erscheinungsjahr: |
2023 |
|---|---|
| Erschienen: |
2023 |
| Enthalten in: |
Zur Gesamtaufnahme - year:2023 |
|---|---|
| Enthalten in: |
Current cancer drug targets - (2023) vom: 13. Apr. |
| Sprache: |
Englisch |
|---|
| Beteiligte Personen: |
Entezari, Maliheh [VerfasserIn] |
|---|
| Links: |
|---|
| Themen: |
Cancer therapy |
|---|
| Anmerkungen: |
Date Revised 18.04.2023 published: Print-Electronic Citation Status Publisher |
|---|
| doi: |
10.2174/1568009623666230413094317 |
|---|
| funding: |
|
|---|---|
| Förderinstitution / Projekttitel: |
|
| PPN (Katalog-ID): |
NLM35573656X |
|---|
| LEADER | 01000naa a22002652 4500 | ||
|---|---|---|---|
| 001 | NLM35573656X | ||
| 003 | DE-627 | ||
| 005 | 20231226064956.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 231226s2023 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.2174/1568009623666230413094317 |2 doi | |
| 028 | 5 | 2 | |a pubmed24n1185.xml |
| 035 | |a (DE-627)NLM35573656X | ||
| 035 | |a (NLM)37069720 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
| 041 | |a eng | ||
| 100 | 1 | |a Entezari, Maliheh |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Wnt/β-catenin Signaling in Lung Cancer |b Association with Proliferation, Metastasis, and Therapy Resistance |
| 264 | 1 | |c 2023 | |
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a ƒaComputermedien |b c |2 rdamedia | ||
| 338 | |a ƒa Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Date Revised 18.04.2023 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status Publisher | ||
| 520 | |a Copyright© Bentham Science Publishers; For any queries, please email at epubbenthamscience.net. | ||
| 520 | |a The capacity of cancer cells for abnormal growth and metastasis has made it difficult to find a cure for tumor. Both males and females suffer from lung tumors, and physicians still deem them incurable. The initiation and development of lung tumors can be forced by genomic mutations. Wnt is a critical pathway for regulating growth, differentiation and migration. However, its oncogenic function has been observed in lung cancer. Wnt is able to increase the proliferation of lung tumors. The metastasis potential of lung tumors can be accelerated by Wnt/EMT axis. Overexpression of Wnt/β-catenin prevents chemotherapy-mediated cell death in lung tumors. This pathway promotes cancer stem cell features in lung tumors which induce radioresistance. Anti-cancer agents, such as curcumin, are able to inhibit Wnt in lung tumor treatment. Wnt interaction with other factors in lung tumors is essential in controlling biological behavior, and non-coding RNA transcripts are the most well-known ones. It can be concluded from the current study that Wnt is an important regulator of lung tumorigenesis, and the translation of these findings into the clinic is vital | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Cancer therapy | |
| 650 | 4 | |a Chemoresistance | |
| 650 | 4 | |a Lung cancer | |
| 650 | 4 | |a Metastasis | |
| 650 | 4 | |a Wnt/?-catenin | |
| 650 | 4 | |a Wnt/?-catenin signaling | |
| 700 | 1 | |a Deldar Abad Paskeh, Mahshid |e verfasserin |4 aut | |
| 700 | 1 | |a Orouei, Sima |e verfasserin |4 aut | |
| 700 | 1 | |a Kakavand, Amirabbas |e verfasserin |4 aut | |
| 700 | 1 | |a Rezaei, Shamin |e verfasserin |4 aut | |
| 700 | 1 | |a Sadat Hejazi, Elahe |e verfasserin |4 aut | |
| 700 | 1 | |a Pashootan, Parya |e verfasserin |4 aut | |
| 700 | 1 | |a Nazdari, Naghmeh |e verfasserin |4 aut | |
| 700 | 1 | |a Tavakolpournegari, Alireza |e verfasserin |4 aut | |
| 700 | 1 | |a Hashemi, Mehrdad |e verfasserin |4 aut | |
| 700 | 1 | |a Salimimoghadam, Shokooh |e verfasserin |4 aut | |
| 700 | 1 | |a Mirzaei, Sepideh |e verfasserin |4 aut | |
| 700 | 1 | |a Taheriazam, Afshin |e verfasserin |4 aut | |
| 700 | 1 | |a Samarghandian, Saeed |e verfasserin |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Current cancer drug targets |d 2001 |g (2023) vom: 13. Apr. |w (DE-627)NLM120490560 |x 1873-5576 |7 nnns |
| 773 | 1 | 8 | |g year:2023 |g day:13 |g month:04 |
| 856 | 4 | 0 | |u http://dx.doi.org/10.2174/1568009623666230413094317 |3 Volltext |
| 912 | |a GBV_USEFLAG_A | ||
| 912 | |a GBV_NLM | ||
| 951 | |a AR | ||
| 952 | |j 2023 |b 13 |c 04 | ||