Role of latent tuberculosis infection on elevated risk of cardiovascular disease : a population-based cohort study of immigrants in British Columbia, Canada, 1985-2019
We investigated cardiovascular disease (CVD) risk associated with latent tuberculosis infection (LTBI) (Aim-1) and LTBI therapy (Aim-2) in British Columbia, a low-tuberculosis-incidence setting. 49,197 participants had valid LTBI test results. Cox proportional hazards model was fitted, adjusting for potential confounders. Compared with the participants who tested LTBI negative, LTBI positive was associated with an 8% higher CVD risk in complete case data (adjusted hazard ratio (HR): 1.08, 95% CI: 0.99-1.18), a statistically significant 11% higher risk when missing confounder values were imputed using multiple imputation (HR: 1.11, 95% CI: 1.02-1.20), and 10% higher risk when additional proxy variables supplementing known unmeasured confounders were incorporated in the highdimensional disease risk score technique to reduce residual confounding (HR: 1.10, 95% CI: 1.01-1.20). Also, compared with participants who tested negative, CVD risk was 27% higher among people who were LTBI positive but incomplete LTBI therapy (HR: 1.27, 95% CI: 1.04-1.55), whereas the risk was similar in people who completed LTBI therapy (HR: 1.04, 95% CI: 0.87-1.24). Findings were consistent in different sensitivity analyses. We concluded that LTBI is associated with an increased CVD risk in low-tuberculosis-incidence settings, with a higher risk associated with incomplete LTBI therapy and attenuated risk when therapy is completed.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2023 |
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| Erschienen: |
2023 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:151 |
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| Enthalten in: |
Epidemiology and infection - 151(2023) vom: 17. Apr., Seite e68 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Hossain, Md Belal [VerfasserIn] |
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| Links: |
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| Themen: |
British Columbia |
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| Anmerkungen: |
Date Completed 06.05.2023 Date Revised 26.05.2023 published: Electronic Citation Status MEDLINE |
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| doi: |
10.1017/S0950268823000559 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM355709988 |
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| 520 | |a We investigated cardiovascular disease (CVD) risk associated with latent tuberculosis infection (LTBI) (Aim-1) and LTBI therapy (Aim-2) in British Columbia, a low-tuberculosis-incidence setting. 49,197 participants had valid LTBI test results. Cox proportional hazards model was fitted, adjusting for potential confounders. Compared with the participants who tested LTBI negative, LTBI positive was associated with an 8% higher CVD risk in complete case data (adjusted hazard ratio (HR): 1.08, 95% CI: 0.99-1.18), a statistically significant 11% higher risk when missing confounder values were imputed using multiple imputation (HR: 1.11, 95% CI: 1.02-1.20), and 10% higher risk when additional proxy variables supplementing known unmeasured confounders were incorporated in the highdimensional disease risk score technique to reduce residual confounding (HR: 1.10, 95% CI: 1.01-1.20). Also, compared with participants who tested negative, CVD risk was 27% higher among people who were LTBI positive but incomplete LTBI therapy (HR: 1.27, 95% CI: 1.04-1.55), whereas the risk was similar in people who completed LTBI therapy (HR: 1.04, 95% CI: 0.87-1.24). Findings were consistent in different sensitivity analyses. We concluded that LTBI is associated with an increased CVD risk in low-tuberculosis-incidence settings, with a higher risk associated with incomplete LTBI therapy and attenuated risk when therapy is completed | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a British Columbia | |
| 650 | 4 | |a cardiovascular disease | |
| 650 | 4 | |a health administrative databases | |
| 650 | 4 | |a latent tuberculosis infection | |
| 650 | 4 | |a low tuberculosis incidence | |
| 700 | 1 | |a Johnston, James C |e verfasserin |4 aut | |
| 700 | 1 | |a Cook, Victoria J |e verfasserin |4 aut | |
| 700 | 1 | |a Sadatsafavi, Mohsen |e verfasserin |4 aut | |
| 700 | 1 | |a Wong, Hubert |e verfasserin |4 aut | |
| 700 | 1 | |a Romanowski, Kamila |e verfasserin |4 aut | |
| 700 | 1 | |a Karim, Mohammad Ehsanul |e verfasserin |4 aut | |
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