Efficient dispersive solid-phase extraction of methylprednisolone from exhaled breath of COVID-19 patients
This journal is © The Royal Society of Chemistry..
In the current study, bismuth ferrite nano-sorbent was synthesized and utilized as a sorbent for the dispersive solid-phase extraction of methylprednisolone from exhaled breath samples. The size and morphology of the nano-sorbent were characterized by X-ray diffraction analysis and scanning electron microscopy. Following its desorption with acetonitrile, methylprednisolone was quantified by a high-performance liquid chromatography-ultraviolet detector. Factors affecting the extraction of methylprednisolone were optimized. Under optimized experimental conditions, a linear relationship between the analytical signals and methylprednisolone concentration was obtained in the range of 0.001-0.2 μg mL-1 for exhaled breath condensate samples and 0.002-0.4 μg per filter for filter samples. A pre-concentration factor of 6.4-fold, corresponding to an extraction recovery of 96.0%, was achieved. The validated method was applied for the determination of methylprednisolone in real samples taken from the exhaled breath of COVID-19 patients under mechanical ventilation.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2023 |
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| Erschienen: |
2023 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:13 |
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| Enthalten in: |
RSC advances - 13(2023), 17 vom: 11. Apr., Seite 11457-11463 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Sefid-Sefidehkhan, Yasaman [VerfasserIn] |
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| Links: |
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| Anmerkungen: |
Date Revised 18.04.2023 published: Electronic-eCollection Citation Status PubMed-not-MEDLINE |
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| doi: |
10.1039/d2ra07902j |
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| funding: |
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| Förderinstitution / Projekttitel: |
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NLM355677652 |
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| 520 | |a In the current study, bismuth ferrite nano-sorbent was synthesized and utilized as a sorbent for the dispersive solid-phase extraction of methylprednisolone from exhaled breath samples. The size and morphology of the nano-sorbent were characterized by X-ray diffraction analysis and scanning electron microscopy. Following its desorption with acetonitrile, methylprednisolone was quantified by a high-performance liquid chromatography-ultraviolet detector. Factors affecting the extraction of methylprednisolone were optimized. Under optimized experimental conditions, a linear relationship between the analytical signals and methylprednisolone concentration was obtained in the range of 0.001-0.2 μg mL-1 for exhaled breath condensate samples and 0.002-0.4 μg per filter for filter samples. A pre-concentration factor of 6.4-fold, corresponding to an extraction recovery of 96.0%, was achieved. The validated method was applied for the determination of methylprednisolone in real samples taken from the exhaled breath of COVID-19 patients under mechanical ventilation | ||
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| 700 | 1 | |a Mahmoodpoor, Ata |e verfasserin |4 aut | |
| 700 | 1 | |a Vaez-Gharamaleki, Yosra |e verfasserin |4 aut | |
| 700 | 1 | |a Khoubnasabjafari, Maryam |e verfasserin |4 aut | |
| 700 | 1 | |a Afshar Moghaddam, Mohammad Reza |e verfasserin |4 aut | |
| 700 | 1 | |a Jouyban-Gharamaleki, Vahid |e verfasserin |4 aut | |
| 700 | 1 | |a Dastmalchi, Siavoush |e verfasserin |4 aut | |
| 700 | 1 | |a Rahimpour, Elaheh |e verfasserin |4 aut | |
| 700 | 1 | |a Jouyban, Abolghasem |e verfasserin |4 aut | |
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