Copper-Catalyzed Hydroxyperfluoroalkylation of Unactivated Alkenes : Access to β-Perfluoroalkyl Alcohols
An expeditious copper-catalyzed three-component hydroxyperfluoroalkylation of unactivated alkenes starting from commercially available perfluoroalkyl iodides and an O2 molecule from air as the oxygen source was developed. The Cu/B2pin2 catalytic system offered a novel pattern for the generation of perfluoroalkyl radicals and overcame the previous limitations in the hydroxyperfluoroalkylation of unactivated alkenes. This catalytic protocol features high regioselectivity and broad substrate scope to access valuable β-perfluoroalkyl alcohols expediently. 18O-labeling experiments demonstrated that the oxygen atom of the OH group stems from O2 in air.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2023 |
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| Erschienen: |
2023 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:25 |
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| Enthalten in: |
Organic letters - 25(2023), 16 vom: 28. Apr., Seite 2782-2787 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Tang, Luqing [VerfasserIn] |
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| Links: |
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| Themen: |
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| Anmerkungen: |
Date Completed 30.04.2023 Date Revised 30.04.2023 published: Print-Electronic Citation Status PubMed-not-MEDLINE |
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| doi: |
10.1021/acs.orglett.3c00651 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM355660393 |
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| 500 | |a Date Revised 30.04.2023 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status PubMed-not-MEDLINE | ||
| 520 | |a An expeditious copper-catalyzed three-component hydroxyperfluoroalkylation of unactivated alkenes starting from commercially available perfluoroalkyl iodides and an O2 molecule from air as the oxygen source was developed. The Cu/B2pin2 catalytic system offered a novel pattern for the generation of perfluoroalkyl radicals and overcame the previous limitations in the hydroxyperfluoroalkylation of unactivated alkenes. This catalytic protocol features high regioselectivity and broad substrate scope to access valuable β-perfluoroalkyl alcohols expediently. 18O-labeling experiments demonstrated that the oxygen atom of the OH group stems from O2 in air | ||
| 650 | 4 | |a Journal Article | |
| 700 | 1 | |a Feng, Cancan |e verfasserin |4 aut | |
| 700 | 1 | |a Yang, Fan |e verfasserin |4 aut | |
| 700 | 1 | |a Wu, Yangjie |e verfasserin |4 aut | |
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