Moderate white light exposure enhanced spatial memory retrieval by activating a central amygdala-involved circuit in mice
© 2023. The Author(s)..
Light exposure can profoundly affect neurological functions and behaviors. Here, we show that short-term exposure to moderate (400 lux) white light during Y-maze test promoted spatial memory retrieval and induced only mild anxiety in mice. This beneficial effect involves the activation of a circuit including neurons in the central amygdala (CeA), locus coeruleus (LC), and dentate gyrus (DG). Specifically, moderate light activated corticotropin-releasing hormone (CRH) positive (+) CeA neurons and induced the release of corticotropin-releasing factor (CRF) from their axon terminals ending in the LC. CRF then activated tyrosine hydroxylase-expressing LC neurons, which send projections to DG and release norepinephrine (NE). NE activated β-adrenergic receptors on CaMKIIα-expressing DG neurons, ultimately promoting spatial memory retrieval. Our study thus demonstrated a specific light scheme that can promote spatial memory without excessive stress, and unraveled the underlying CeA-LC-DG circuit and associated neurochemical mechanisms.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2023 |
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| Erschienen: |
2023 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:6 |
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| Enthalten in: |
Communications biology - 6(2023), 1 vom: 14. Apr., Seite 414 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Shang, MengJuan [VerfasserIn] |
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| Links: |
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| Themen: |
9015-71-8 |
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| Anmerkungen: |
Date Completed 18.04.2023 Date Revised 21.04.2023 published: Electronic Citation Status MEDLINE |
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| doi: |
10.1038/s42003-023-04765-7 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM355638789 |
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| 520 | |a © 2023. The Author(s). | ||
| 520 | |a Light exposure can profoundly affect neurological functions and behaviors. Here, we show that short-term exposure to moderate (400 lux) white light during Y-maze test promoted spatial memory retrieval and induced only mild anxiety in mice. This beneficial effect involves the activation of a circuit including neurons in the central amygdala (CeA), locus coeruleus (LC), and dentate gyrus (DG). Specifically, moderate light activated corticotropin-releasing hormone (CRH) positive (+) CeA neurons and induced the release of corticotropin-releasing factor (CRF) from their axon terminals ending in the LC. CRF then activated tyrosine hydroxylase-expressing LC neurons, which send projections to DG and release norepinephrine (NE). NE activated β-adrenergic receptors on CaMKIIα-expressing DG neurons, ultimately promoting spatial memory retrieval. Our study thus demonstrated a specific light scheme that can promote spatial memory without excessive stress, and unraveled the underlying CeA-LC-DG circuit and associated neurochemical mechanisms | ||
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| 700 | 1 | |a Xu, RuoTong |e verfasserin |4 aut | |
| 700 | 1 | |a Du, JingYu |e verfasserin |4 aut | |
| 700 | 1 | |a Zhang, JiMeng |e verfasserin |4 aut | |
| 700 | 1 | |a OuYang, Ding |e verfasserin |4 aut | |
| 700 | 1 | |a Du, JunZe |e verfasserin |4 aut | |
| 700 | 1 | |a Hu, JunFeng |e verfasserin |4 aut | |
| 700 | 1 | |a Sun, ZhiChuan |e verfasserin |4 aut | |
| 700 | 1 | |a Wang, BingXia |e verfasserin |4 aut | |
| 700 | 1 | |a Han, Qian |e verfasserin |4 aut | |
| 700 | 1 | |a Hu, Yang |e verfasserin |4 aut | |
| 700 | 1 | |a Liu, YiHong |e verfasserin |4 aut | |
| 700 | 1 | |a Guan, Yun |e verfasserin |4 aut | |
| 700 | 1 | |a Li, Jing |e verfasserin |4 aut | |
| 700 | 1 | |a Guo, GuoZhen |e verfasserin |4 aut | |
| 700 | 1 | |a Xing, JunLing |e verfasserin |4 aut | |
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