OBERON3 and SUPPRESSOR OF MAX2 1-LIKE proteins form a regulatory module driving phloem development
© 2023. The Author(s)..
Spatial specificity of cell fate decisions is central for organismal development. The phloem tissue mediates long-distance transport of energy metabolites along plant bodies and is characterized by an exceptional degree of cellular specialization. How a phloem-specific developmental program is implemented is, however, unknown. Here we reveal that the ubiquitously expressed PHD-finger protein OBE3 forms a central module with the phloem-specific SMXL5 protein for establishing the phloem developmental program in Arabidopsis thaliana. By protein interaction studies and phloem-specific ATAC-seq analyses, we show that OBE3 and SMXL5 proteins form a complex in nuclei of phloem stem cells where they promote a phloem-specific chromatin profile. This profile allows expression of OPS, BRX, BAM3, and CVP2 genes acting as mediators of phloem differentiation. Our findings demonstrate that OBE3/SMXL5 protein complexes establish nuclear features essential for determining phloem cell fate and highlight how a combination of ubiquitous and local regulators generate specificity of developmental decisions in plants.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2023 |
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| Erschienen: |
2023 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:14 |
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| Enthalten in: |
Nature communications - 14(2023), 1 vom: 14. Apr., Seite 2128 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Wallner, Eva-Sophie [VerfasserIn] |
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| Links: |
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| Themen: |
Arabidopsis Proteins |
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| Anmerkungen: |
Date Completed 18.04.2023 Date Revised 21.04.2023 published: Electronic Citation Status MEDLINE |
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| doi: |
10.1038/s41467-023-37790-5 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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NLM355638770 |
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| 520 | |a © 2023. The Author(s). | ||
| 520 | |a Spatial specificity of cell fate decisions is central for organismal development. The phloem tissue mediates long-distance transport of energy metabolites along plant bodies and is characterized by an exceptional degree of cellular specialization. How a phloem-specific developmental program is implemented is, however, unknown. Here we reveal that the ubiquitously expressed PHD-finger protein OBE3 forms a central module with the phloem-specific SMXL5 protein for establishing the phloem developmental program in Arabidopsis thaliana. By protein interaction studies and phloem-specific ATAC-seq analyses, we show that OBE3 and SMXL5 proteins form a complex in nuclei of phloem stem cells where they promote a phloem-specific chromatin profile. This profile allows expression of OPS, BRX, BAM3, and CVP2 genes acting as mediators of phloem differentiation. Our findings demonstrate that OBE3/SMXL5 protein complexes establish nuclear features essential for determining phloem cell fate and highlight how a combination of ubiquitous and local regulators generate specificity of developmental decisions in plants | ||
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| 700 | 1 | |a Tonn, Nina |e verfasserin |4 aut | |
| 700 | 1 | |a Shi, Dongbo |e verfasserin |4 aut | |
| 700 | 1 | |a Luzzietti, Laura |e verfasserin |4 aut | |
| 700 | 1 | |a Wanke, Friederike |e verfasserin |4 aut | |
| 700 | 1 | |a Hunziker, Pascal |e verfasserin |4 aut | |
| 700 | 1 | |a Xu, Yingqiang |e verfasserin |4 aut | |
| 700 | 1 | |a Jung, Ilona |e verfasserin |4 aut | |
| 700 | 1 | |a Lopéz-Salmerón, Vadir |e verfasserin |4 aut | |
| 700 | 1 | |a Gebert, Michael |e verfasserin |4 aut | |
| 700 | 1 | |a Wenzl, Christian |e verfasserin |4 aut | |
| 700 | 1 | |a Lohmann, Jan U |e verfasserin |4 aut | |
| 700 | 1 | |a Harter, Klaus |e verfasserin |4 aut | |
| 700 | 1 | |a Greb, Thomas |e verfasserin |4 aut | |
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