Fluorescence-guided and molecularly-guided debridement : identifying devitalized and infected tissue in orthopaedic trauma
Following orthopaedic trauma, bone devitalization is a critical determinant of complications such as infection or nonunion. Intraoperative assessment of bone perfusion has thus far been limited. Furthermore, treatment failure for infected fractures is unreasonably high, owing to the propensity of biofilm to form and become entrenched in poorly vascularized bone. Fluorescence-guided surgery and molecularly-guided surgery could be used to evaluate the viability of bone and soft tissue and detect the presence of planktonic and biofilm-forming bacteria. This proceedings paper discusses the motivation behind developing this technology and our most recent preclinical and clinical results.
| Medienart: |
E-Artikel |
|---|
| Erscheinungsjahr: |
2023 |
|---|---|
| Erschienen: |
2023 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:12361 |
|---|---|
| Enthalten in: |
Proceedings of SPIE--the International Society for Optical Engineering - 12361(2023) vom: 11. Jan. |
| Sprache: |
Englisch |
|---|
| Beteiligte Personen: |
Elliott, Jonathan Thomas [VerfasserIn] |
|---|
| Links: |
|---|
| Themen: |
Dynamic contrast-enhanced fluorescence imaging |
|---|
| Anmerkungen: |
Date Revised 31.10.2023 published: Print-Electronic Citation Status PubMed-not-MEDLINE |
|---|
| doi: |
10.1117/12.2661243 |
|---|
| funding: |
|
|---|---|
| Förderinstitution / Projekttitel: |
|
| PPN (Katalog-ID): |
NLM355612968 |
|---|
| LEADER | 01000naa a22002652 4500 | ||
|---|---|---|---|
| 001 | NLM355612968 | ||
| 003 | DE-627 | ||
| 005 | 20231226064719.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 231226s2023 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1117/12.2661243 |2 doi | |
| 028 | 5 | 2 | |a pubmed24n1185.xml |
| 035 | |a (DE-627)NLM355612968 | ||
| 035 | |a (NLM)37056956 | ||
| 035 | |a (PII)1236108 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
| 041 | |a eng | ||
| 100 | 1 | |a Elliott, Jonathan Thomas |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Fluorescence-guided and molecularly-guided debridement |b identifying devitalized and infected tissue in orthopaedic trauma |
| 264 | 1 | |c 2023 | |
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a ƒaComputermedien |b c |2 rdamedia | ||
| 338 | |a ƒa Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Date Revised 31.10.2023 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status PubMed-not-MEDLINE | ||
| 520 | |a Following orthopaedic trauma, bone devitalization is a critical determinant of complications such as infection or nonunion. Intraoperative assessment of bone perfusion has thus far been limited. Furthermore, treatment failure for infected fractures is unreasonably high, owing to the propensity of biofilm to form and become entrenched in poorly vascularized bone. Fluorescence-guided surgery and molecularly-guided surgery could be used to evaluate the viability of bone and soft tissue and detect the presence of planktonic and biofilm-forming bacteria. This proceedings paper discusses the motivation behind developing this technology and our most recent preclinical and clinical results | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Fluorescence-guided surgery | |
| 650 | 4 | |a dynamic contrast-enhanced fluorescence imaging | |
| 650 | 4 | |a indocyanine green imaging | |
| 650 | 4 | |a necrotizing soft-tissue infections | |
| 650 | 4 | |a orthopaedic surgery | |
| 700 | 1 | |a Henderson, Eric |e verfasserin |4 aut | |
| 700 | 1 | |a Streeter, Samuel S |e verfasserin |4 aut | |
| 700 | 1 | |a Demidov, Valentin |e verfasserin |4 aut | |
| 700 | 1 | |a Han, Xinyue |e verfasserin |4 aut | |
| 700 | 1 | |a Tang, Yue |e verfasserin |4 aut | |
| 700 | 1 | |a Sottosanti, J Scott |e verfasserin |4 aut | |
| 700 | 1 | |a Bateman, Logan |e verfasserin |4 aut | |
| 700 | 1 | |a Brůža, Petr |e verfasserin |4 aut | |
| 700 | 1 | |a Jiang, Shudong |e verfasserin |4 aut | |
| 700 | 1 | |a Gitajn, I Leah |e verfasserin |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Proceedings of SPIE--the International Society for Optical Engineering |d 1984 |g 12361(2023) vom: 11. Jan. |w (DE-627)NLM166567531 |x 0277-786X |7 nnns |
| 773 | 1 | 8 | |g volume:12361 |g year:2023 |g day:11 |g month:01 |
| 856 | 4 | 0 | |u http://dx.doi.org/10.1117/12.2661243 |3 Volltext |
| 912 | |a GBV_USEFLAG_A | ||
| 912 | |a GBV_NLM | ||
| 951 | |a AR | ||
| 952 | |d 12361 |j 2023 |b 11 |c 01 | ||