Evaluation of functional warm ischemia time during controlled donation after circulatory determination of death using normothermic regional perfusion (ECMO-TT) : A prospective multicenter cohort study
© 2023 The Authors. Artificial Organs published by International Center for Artificial Organ and Transplantation (ICAOT) and Wiley Periodicals LLC..
BACKGROUND: Controlled donation after circulatory determination of death (cDCD) seems an effective way to mitigate the critical shortage of available organs for transplant worldwide. As a recently developed procedure for organ retrieval, some questions remain unsolved such as the uncertainty regarding the effect of functional warm ischemia time (FWIT) on organs´ viability.
METHODS: We developed a multicenter prospective cohort study collecting all data from evaluated organs during cDCD from 2017 to 2020. All the procedures related to cDCD were performed with normothermic regional perfusion. The analysis included organ retrieval as endpoint and FWIT as exposure of interest. The effect of FWIT on the likelihood for organ retrieval was evaluated with Relative distribution analysis.
RESULTS: A total amount of 507 organs´ related information was analyzed from 95 organ donors. Median donor age was 62 years, and 63% of donors were male. Stroke was the most common diagnosis before withdrawal of life-sustaining therapy (61%), followed by anoxic encephalopathy (21%). This analysis showed that length of FWIT was inversely associated with organ retrieval rates for liver, kidneys, and pancreas. No statistically significant association was found for lungs.
CONCLUSIONS: Results showed an inverse association between functional warm ischemia time (FWIT) and retrieval rate. We also have postulated optimal FWIT's thresholds for organ retrieval. FWIT for liver retrieval remained between 6 and less than 11 min and in case of kidneys and pancreas, the optimal FWIT for retrieval was 6 to 12 min. These results could be valuable to improve organ utilization and for future analysis.
Medienart: |
E-Artikel |
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Erscheinungsjahr: |
2023 |
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Erschienen: |
2023 |
Enthalten in: |
Zur Gesamtaufnahme - volume:47 |
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Enthalten in: |
Artificial organs - 47(2023), 8 vom: 21. Aug., Seite 1371-1385 |
Sprache: |
Englisch |
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Beteiligte Personen: |
Martínez-Castro, Sara [VerfasserIn] |
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Links: |
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Anmerkungen: |
Date Completed 05.09.2023 Date Revised 05.09.2023 published: Print-Electronic Citation Status MEDLINE |
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doi: |
10.1111/aor.14539 |
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funding: |
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Förderinstitution / Projekttitel: |
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PPN (Katalog-ID): |
NLM355470608 |
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245 | 1 | 0 | |a Evaluation of functional warm ischemia time during controlled donation after circulatory determination of death using normothermic regional perfusion (ECMO-TT) |b A prospective multicenter cohort study |
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520 | |a © 2023 The Authors. Artificial Organs published by International Center for Artificial Organ and Transplantation (ICAOT) and Wiley Periodicals LLC. | ||
520 | |a BACKGROUND: Controlled donation after circulatory determination of death (cDCD) seems an effective way to mitigate the critical shortage of available organs for transplant worldwide. As a recently developed procedure for organ retrieval, some questions remain unsolved such as the uncertainty regarding the effect of functional warm ischemia time (FWIT) on organs´ viability | ||
520 | |a METHODS: We developed a multicenter prospective cohort study collecting all data from evaluated organs during cDCD from 2017 to 2020. All the procedures related to cDCD were performed with normothermic regional perfusion. The analysis included organ retrieval as endpoint and FWIT as exposure of interest. The effect of FWIT on the likelihood for organ retrieval was evaluated with Relative distribution analysis | ||
520 | |a RESULTS: A total amount of 507 organs´ related information was analyzed from 95 organ donors. Median donor age was 62 years, and 63% of donors were male. Stroke was the most common diagnosis before withdrawal of life-sustaining therapy (61%), followed by anoxic encephalopathy (21%). This analysis showed that length of FWIT was inversely associated with organ retrieval rates for liver, kidneys, and pancreas. No statistically significant association was found for lungs | ||
520 | |a CONCLUSIONS: Results showed an inverse association between functional warm ischemia time (FWIT) and retrieval rate. We also have postulated optimal FWIT's thresholds for organ retrieval. FWIT for liver retrieval remained between 6 and less than 11 min and in case of kidneys and pancreas, the optimal FWIT for retrieval was 6 to 12 min. These results could be valuable to improve organ utilization and for future analysis | ||
650 | 4 | |a Multicenter Study | |
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650 | 4 | |a controlled donation after circulatory determination of death | |
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650 | 4 | |a organ transplantation | |
650 | 4 | |a withdrawal of life-sustaining therapy | |
700 | 1 | |a Navarro, Rosalía |e verfasserin |4 aut | |
700 | 1 | |a García-Pérez, María Luisa |e verfasserin |4 aut | |
700 | 1 | |a Segura, José Manuel |e verfasserin |4 aut | |
700 | 1 | |a Carbonell, José A |e verfasserin |4 aut | |
700 | 1 | |a Hornero, Fernando |e verfasserin |4 aut | |
700 | 1 | |a Guijarro, Jorge |e verfasserin |4 aut | |
700 | 1 | |a Zaplana, Marta |e verfasserin |4 aut | |
700 | 1 | |a Bruño, María Ángeles |e verfasserin |4 aut | |
700 | 1 | |a Tur, Ana |e verfasserin |4 aut | |
700 | 1 | |a Martínez-León, Juan Bautista |e verfasserin |4 aut | |
700 | 1 | |a Zaragoza, Rafael |e verfasserin |4 aut | |
700 | 1 | |a Núñez, Julio |e verfasserin |4 aut | |
700 | 1 | |a Domínguez-Gil, Beatriz |e verfasserin |4 aut | |
700 | 1 | |a Badenes, Rafael |e verfasserin |4 aut | |
700 | 0 | |a ECMO TRANSPLANT TEAM Study Group |e verfasserin |4 aut | |
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700 | 1 | |a Guillen, Antonio |e investigator |4 oth | |
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700 | 1 | |a Gracia, Juan Manuel |e investigator |4 oth | |
700 | 1 | |a Domenech, Alberto |e investigator |4 oth | |
700 | 1 | |a Rengel-Ruiz, Marcelo |e investigator |4 oth | |
700 | 1 | |a Schröer, Volker |e investigator |4 oth | |
700 | 1 | |a Casula, Elisabetta |e investigator |4 oth | |
700 | 1 | |a Sanchis, Juan Manuel |e investigator |4 oth | |
700 | 1 | |a Sala-Almonacil, Vicente A |e investigator |4 oth | |
700 | 1 | |a Altable, Mario |e investigator |4 oth | |
700 | 1 | |a Esteller, Joan |e investigator |4 oth | |
700 | 1 | |a Palau, Rocío |e investigator |4 oth | |
700 | 1 | |a Alabau, José |e investigator |4 oth | |
700 | 1 | |a Guevara, Audelio |e investigator |4 oth | |
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