Sensitivity to change of generic preference-based instruments (EQ-5D-3L, EQ-5D-5L, and HUI3) in the context of treatment for people with prescription-type opioid use disorder in Canada
© 2023. The Author(s)..
PURPOSE: Using data from a randomized controlled trial for treatment of prescription-type opioid use disorder in Canada, this study examines sensitivity to change in three preference-based instruments [EQ-5D-3L, EQ-5D-5L, and the Health Utilities Index Mark 3 (HUI3)] and explores an oft-overlooked consideration when working with contemporaneous responses for similar questions-data quality.
METHODS: Analyses focused on the relative abilities of three instruments to capture change in health status. Distributional methods were used to categorize individuals as 'improved' or 'not improved' for eight anchors (seven clinical, one generic). Sensitivity to change was assessed using area under the ROC (receiver operating characteristics) curve (AUC) analysis and comparisons of mean change scores for three time periods. A 'strict' data quality criteria, defined a priori, was applied. Analyses were replicated using 'soft' and 'no' criteria.
RESULTS: Data from 160 individuals were used in the analysis; 30% had at least one data quality violation at baseline. Despite mean index scores being significantly lower for the HUI3 compared with EQ-5D instruments at each time point, the magnitudes of change scores were similar. No instrument demonstrated superior sensitivity to change. While six of the 10 highest AUC estimates were for the HUI3, 'moderate' classifications of discriminative ability were identified in 12 (of 22) analyses for each EQ-5D instrument, compared with eight for the HUI3.
CONCLUSION: Negligible differences were observed between the EQ-5D-3L, EQ-5D-5L, and HUI3 regarding the ability to measure change. The prevalence of data quality violations-which differed by ethnicity-requires further investigation.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2023 |
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| Erschienen: |
2023 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:32 |
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| Enthalten in: |
Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation - 32(2023), 8 vom: 07. Aug., Seite 2209-2221 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Whitehurst, David G T [VerfasserIn] |
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| Links: |
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| Themen: |
EQ-5D |
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| Anmerkungen: |
Date Completed 10.07.2023 Date Revised 26.07.2023 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1007/s11136-023-03381-6 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM355317478 |
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| 100 | 1 | |a Whitehurst, David G T |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Sensitivity to change of generic preference-based instruments (EQ-5D-3L, EQ-5D-5L, and HUI3) in the context of treatment for people with prescription-type opioid use disorder in Canada |
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| 500 | |a Date Revised 26.07.2023 | ||
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| 500 | |a Citation Status MEDLINE | ||
| 520 | |a © 2023. The Author(s). | ||
| 520 | |a PURPOSE: Using data from a randomized controlled trial for treatment of prescription-type opioid use disorder in Canada, this study examines sensitivity to change in three preference-based instruments [EQ-5D-3L, EQ-5D-5L, and the Health Utilities Index Mark 3 (HUI3)] and explores an oft-overlooked consideration when working with contemporaneous responses for similar questions-data quality | ||
| 520 | |a METHODS: Analyses focused on the relative abilities of three instruments to capture change in health status. Distributional methods were used to categorize individuals as 'improved' or 'not improved' for eight anchors (seven clinical, one generic). Sensitivity to change was assessed using area under the ROC (receiver operating characteristics) curve (AUC) analysis and comparisons of mean change scores for three time periods. A 'strict' data quality criteria, defined a priori, was applied. Analyses were replicated using 'soft' and 'no' criteria | ||
| 520 | |a RESULTS: Data from 160 individuals were used in the analysis; 30% had at least one data quality violation at baseline. Despite mean index scores being significantly lower for the HUI3 compared with EQ-5D instruments at each time point, the magnitudes of change scores were similar. No instrument demonstrated superior sensitivity to change. While six of the 10 highest AUC estimates were for the HUI3, 'moderate' classifications of discriminative ability were identified in 12 (of 22) analyses for each EQ-5D instrument, compared with eight for the HUI3 | ||
| 520 | |a CONCLUSION: Negligible differences were observed between the EQ-5D-3L, EQ-5D-5L, and HUI3 regarding the ability to measure change. The prevalence of data quality violations-which differed by ethnicity-requires further investigation | ||
| 650 | 4 | |a Randomized Controlled Trial | |
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a EQ-5D | |
| 650 | 4 | |a Health Utilities Index | |
| 650 | 4 | |a Opioid use disorder | |
| 650 | 4 | |a Quality-adjusted life years | |
| 650 | 4 | |a Responsiveness | |
| 650 | 4 | |a Sensitivity to change | |
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| 700 | 1 | |a Krebs, Emanuel |e verfasserin |4 aut | |
| 700 | 1 | |a Enns, Benjamin |e verfasserin |4 aut | |
| 700 | 1 | |a Socias, M Eugenia |e verfasserin |4 aut | |
| 700 | 1 | |a Jutras-Aswad, Didier |e verfasserin |4 aut | |
| 700 | 1 | |a Le Foll, Bernard |e verfasserin |4 aut | |
| 700 | 1 | |a Nosyk, Bohdan |e verfasserin |4 aut | |
| 700 | 0 | |a OPTIMA Research Group within the Canadian Research Initiative in Substance Misuse |e verfasserin |4 aut | |
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