Dynamic changes in nocturnal heart rate predict short-term cardiovascular events in patients using the wearable cardioverter-defibrillator : from the WEARIT-France cohort study
© The Author(s) 2023. Published by Oxford University Press on behalf of the European Society of Cardiology..
AIMS: While elevated resting heart rate measured at a single point of time has been associated with cardiovascular outcomes, utility of continuous monitoring of nocturnal heart rate (NHR) has never been evaluated. We hypothesized that dynamic NHR changes may predict, at short term, impending cardiovascular events in patients equipped with a wearable cardioverter-defibrillator (WCD).
METHODS AND RESULTS: The WEARIT-France prospective cohort study enrolled heart failure patients with WCD between 2014 and 2018. Night-time was defined as midnight to 7 a.m. NHR initial trajectories were classified into four categories based on mean NHR in the first week (High/Low) and NHR evolution over the second week (Up/Down) of WCD use. The primary endpoint was a composite of cardiovascular death and heart failure hospitalization. A total of 1013 [61 (interquartile range, IQR 53-68) years, 16% women, left ventricular ejection fraction 26% (IQR 22-30)] were included. During a median WCD wear duration of 68 (IQR 44-90) days, 58 patients (6%) experienced 69 events. After considering potential confounders, High-Up NHR trajectory was significantly associated with the primary endpoint compared to Low-Down [adjusted hazard ratio (HR) 6.08, 95% confidence interval (CI) 2.56-14.45, P < 0.001]. Additionally, a rise of >5 bpm in weekly average NHR from the preceding week was associated with 2.5 higher composite event risk (HR 2.51, 95% CI 1.22-5.18, P = 0.012) as well as total mortality (HR 11.21, 95% CI 3.55-35.37, P < 0.001) and cardiovascular hospitalization (HR 2.70, 95% CI 1.51-4.82, P < 0.001).
CONCLUSION: Dynamic monitoring of NHR may allow timely identification of impending cardiovascular events, with the potential for 'pre-emptive' action.
REGISTRATION NUMBER: Clinical Trials.gov Identifier: NCT03319160.
| Medienart: |
E-Artikel |
|---|
| Erscheinungsjahr: |
2023 |
|---|---|
| Erschienen: |
2023 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:25 |
|---|---|
| Enthalten in: |
Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology - 25(2023), 5 vom: 19. Mai |
| Sprache: |
Englisch |
|---|
| Beteiligte Personen: |
Garcia, Rodrigue [VerfasserIn] |
|---|
| Links: |
|---|
| Themen: |
Heart failure |
|---|
| Anmerkungen: |
Date Completed 31.05.2023 Date Revised 23.08.2023 published: Print ClinicalTrials.gov: NCT03319160 Citation Status MEDLINE |
|---|
| doi: |
10.1093/europace/euad062 |
|---|
| funding: |
|
|---|---|
| Förderinstitution / Projekttitel: |
|
| PPN (Katalog-ID): |
NLM355260484 |
|---|
| LEADER | 01000naa a22002652 4500 | ||
|---|---|---|---|
| 001 | NLM355260484 | ||
| 003 | DE-627 | ||
| 005 | 20231226063957.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 231226s2023 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1093/europace/euad062 |2 doi | |
| 028 | 5 | 2 | |a pubmed24n1184.xml |
| 035 | |a (DE-627)NLM355260484 | ||
| 035 | |a (NLM)37021342 | ||
| 035 | |a (PII)euad062 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
| 041 | |a eng | ||
| 100 | 1 | |a Garcia, Rodrigue |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Dynamic changes in nocturnal heart rate predict short-term cardiovascular events in patients using the wearable cardioverter-defibrillator |b from the WEARIT-France cohort study |
| 264 | 1 | |c 2023 | |
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a ƒaComputermedien |b c |2 rdamedia | ||
| 338 | |a ƒa Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Date Completed 31.05.2023 | ||
| 500 | |a Date Revised 23.08.2023 | ||
| 500 | |a published: Print | ||
| 500 | |a ClinicalTrials.gov: NCT03319160 | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a © The Author(s) 2023. Published by Oxford University Press on behalf of the European Society of Cardiology. | ||
| 520 | |a AIMS: While elevated resting heart rate measured at a single point of time has been associated with cardiovascular outcomes, utility of continuous monitoring of nocturnal heart rate (NHR) has never been evaluated. We hypothesized that dynamic NHR changes may predict, at short term, impending cardiovascular events in patients equipped with a wearable cardioverter-defibrillator (WCD) | ||
| 520 | |a METHODS AND RESULTS: The WEARIT-France prospective cohort study enrolled heart failure patients with WCD between 2014 and 2018. Night-time was defined as midnight to 7 a.m. NHR initial trajectories were classified into four categories based on mean NHR in the first week (High/Low) and NHR evolution over the second week (Up/Down) of WCD use. The primary endpoint was a composite of cardiovascular death and heart failure hospitalization. A total of 1013 [61 (interquartile range, IQR 53-68) years, 16% women, left ventricular ejection fraction 26% (IQR 22-30)] were included. During a median WCD wear duration of 68 (IQR 44-90) days, 58 patients (6%) experienced 69 events. After considering potential confounders, High-Up NHR trajectory was significantly associated with the primary endpoint compared to Low-Down [adjusted hazard ratio (HR) 6.08, 95% confidence interval (CI) 2.56-14.45, P < 0.001]. Additionally, a rise of >5 bpm in weekly average NHR from the preceding week was associated with 2.5 higher composite event risk (HR 2.51, 95% CI 1.22-5.18, P = 0.012) as well as total mortality (HR 11.21, 95% CI 3.55-35.37, P < 0.001) and cardiovascular hospitalization (HR 2.70, 95% CI 1.51-4.82, P < 0.001) | ||
| 520 | |a CONCLUSION: Dynamic monitoring of NHR may allow timely identification of impending cardiovascular events, with the potential for 'pre-emptive' action | ||
| 520 | |a REGISTRATION NUMBER: Clinical Trials.gov Identifier: NCT03319160 | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Heart failure | |
| 650 | 4 | |a Heart rate | |
| 650 | 4 | |a Pre-emptive action | |
| 650 | 4 | |a Remote monitoring | |
| 650 | 4 | |a Wearable cardioverter-defibrillator | |
| 700 | 1 | |a Warming, Peder Emil |e verfasserin |4 aut | |
| 700 | 1 | |a Narayanan, Kumar |e verfasserin |4 aut | |
| 700 | 1 | |a Defaye, Pascal |e verfasserin |4 aut | |
| 700 | 1 | |a Guedon-Moreau, Laurence |e verfasserin |4 aut | |
| 700 | 1 | |a Blangy, Hugues |e verfasserin |4 aut | |
| 700 | 1 | |a Piot, Olivier |e verfasserin |4 aut | |
| 700 | 1 | |a Leclercq, Christophe |e verfasserin |4 aut | |
| 700 | 1 | |a Marijon, Eloi |e verfasserin |4 aut | |
| 700 | 0 | |a WEARIT-France Investigators |e verfasserin |4 aut | |
| 700 | 1 | |a Moreau, Laurence Guedon |e investigator |4 oth | |
| 700 | 1 | |a Mahfoud, Mohanad |e investigator |4 oth | |
| 700 | 1 | |a Ritter, Philippe |e investigator |4 oth | |
| 700 | 1 | |a Dupuis, Jean Marc |e investigator |4 oth | |
| 700 | 1 | |a Yalioua, Arab |e investigator |4 oth | |
| 700 | 1 | |a Dompnier, Antoine |e investigator |4 oth | |
| 700 | 1 | |a Goralski, Marc |e investigator |4 oth | |
| 700 | 1 | |a Cheggour, Saïda |e investigator |4 oth | |
| 700 | 1 | |a Leclercq, Christophe |e investigator |4 oth | |
| 700 | 1 | |a Marijon, Eloi |e investigator |4 oth | |
| 700 | 1 | |a Bouet, Jérôme |e investigator |4 oth | |
| 700 | 1 | |a André, Clémentine |e investigator |4 oth | |
| 700 | 1 | |a Extramiana, Fabrice |e investigator |4 oth | |
| 700 | 1 | |a Briand, Florent |e investigator |4 oth | |
| 700 | 1 | |a Rollin, Anne |e investigator |4 oth | |
| 700 | 1 | |a Lande, Gilles |e investigator |4 oth | |
| 700 | 1 | |a Chevalier, Philippe |e investigator |4 oth | |
| 700 | 1 | |a Pasquié, Jean-Luc |e investigator |4 oth | |
| 700 | 1 | |a Lellouche, Nicolas |e investigator |4 oth | |
| 700 | 1 | |a Degand, Bruno |e investigator |4 oth | |
| 700 | 1 | |a Cottin, Yves |e investigator |4 oth | |
| 700 | 1 | |a Jourda, François |e investigator |4 oth | |
| 700 | 1 | |a Mansourati, Jacques |e investigator |4 oth | |
| 700 | 1 | |a Martin, Angeline |e investigator |4 oth | |
| 700 | 1 | |a Da Costa, Antoine |e investigator |4 oth | |
| 700 | 1 | |a Billon, Olivier |e investigator |4 oth | |
| 700 | 1 | |a Cheradame, Isabelle |e investigator |4 oth | |
| 700 | 1 | |a Hermida, Jean-Sylvain |e investigator |4 oth | |
| 700 | 1 | |a Bayard, Julien |e investigator |4 oth | |
| 700 | 1 | |a Eschalier, Romain |e investigator |4 oth | |
| 700 | 1 | |a Moyat, Benoit Guy |e investigator |4 oth | |
| 700 | 1 | |a Manenti, Vladimir |e investigator |4 oth | |
| 700 | 1 | |a Gorka, Hervé |e investigator |4 oth | |
| 700 | 1 | |a Combes, Nicolas |e investigator |4 oth | |
| 700 | 1 | |a Milhem, Antoine |e investigator |4 oth | |
| 700 | 1 | |a Piot, Olivier |e investigator |4 oth | |
| 700 | 1 | |a Guyomar, Yves |e investigator |4 oth | |
| 700 | 1 | |a Fouché, Renaud |e investigator |4 oth | |
| 700 | 1 | |a Litoux, Elisabeth Somody |e investigator |4 oth | |
| 700 | 1 | |a Quentin, Anne |e investigator |4 oth | |
| 700 | 1 | |a Berneau, Jean Baptiste |e investigator |4 oth | |
| 700 | 1 | |a Tibi, Thierry |e investigator |4 oth | |
| 700 | 1 | |a Miralles, Aurélien |e investigator |4 oth | |
| 700 | 1 | |a Salerno, Fiorella |e investigator |4 oth | |
| 700 | 1 | |a Jacon, Peggy |e investigator |4 oth | |
| 700 | 1 | |a Nitu, Laurentin |e investigator |4 oth | |
| 700 | 1 | |a Brunet, Damien |e investigator |4 oth | |
| 700 | 1 | |a Bader, Hugues |e investigator |4 oth | |
| 700 | 1 | |a Savoure, Arnaud |e investigator |4 oth | |
| 700 | 1 | |a Sagnol, Pascal |e investigator |4 oth | |
| 700 | 1 | |a Sebag, Frédéric |e investigator |4 oth | |
| 700 | 1 | |a Buffler, Sebastien |e investigator |4 oth | |
| 700 | 1 | |a Fedida, Joël |e investigator |4 oth | |
| 700 | 1 | |a Pineau, Julien |e investigator |4 oth | |
| 700 | 1 | |a De Geeter, Guillaume |e investigator |4 oth | |
| 700 | 1 | |a Zemmoura, Adlane |e investigator |4 oth | |
| 700 | 1 | |a Salhi, Ahmed |e investigator |4 oth | |
| 700 | 1 | |a Verbrugge, Eric |e investigator |4 oth | |
| 700 | 1 | |a Pynn, Sophie |e investigator |4 oth | |
| 700 | 1 | |a Gueffet, Jean Pierre |e investigator |4 oth | |
| 700 | 1 | |a Amara, Walid |e investigator |4 oth | |
| 700 | 1 | |a Seemann, Aurélien |e investigator |4 oth | |
| 700 | 1 | |a Winum, Pierre |e investigator |4 oth | |
| 700 | 1 | |a Johnson, Nicolas |e investigator |4 oth | |
| 700 | 1 | |a Vanesson, Claire |e investigator |4 oth | |
| 700 | 1 | |a Mechulan, Alexis |e investigator |4 oth | |
| 700 | 1 | |a Hugon, Vincent |e investigator |4 oth | |
| 700 | 1 | |a Marchand, Xavier |e investigator |4 oth | |
| 700 | 1 | |a Deharo, Jean-Claude |e investigator |4 oth | |
| 700 | 1 | |a Reuter, Sylvain |e investigator |4 oth | |
| 700 | 1 | |a Sandras, Raphael |e investigator |4 oth | |
| 700 | 1 | |a Legalloi, Damien |e investigator |4 oth | |
| 700 | 1 | |a Garrier, Olivier |e investigator |4 oth | |
| 700 | 1 | |a Jauvert, Gaël |e investigator |4 oth | |
| 700 | 1 | |a Descoux, Jérémy |e investigator |4 oth | |
| 700 | 1 | |a Blangy, Hugues |e investigator |4 oth | |
| 700 | 1 | |a Lebon, Alain |e investigator |4 oth | |
| 700 | 1 | |a Sultan, Pierre |e investigator |4 oth | |
| 700 | 1 | |a Sibellas, Franck |e investigator |4 oth | |
| 700 | 1 | |a Mousi, Samer |e investigator |4 oth | |
| 700 | 1 | |a Laurent, Gabriel |e investigator |4 oth | |
| 700 | 1 | |a Pons, Maxime |e investigator |4 oth | |
| 700 | 1 | |a Marzak, Halim |e investigator |4 oth | |
| 700 | 1 | |a Clerc, Jérôme |e investigator |4 oth | |
| 700 | 1 | |a Barake, Hassan |e investigator |4 oth | |
| 700 | 1 | |a Guiot, Aurélie |e investigator |4 oth | |
| 700 | 1 | |a Algalarrondo, Vincent |e investigator |4 oth | |
| 700 | 1 | |a Palud, Laurent |e investigator |4 oth | |
| 700 | 1 | |a Raguin, Denis |e investigator |4 oth | |
| 700 | 1 | |a Treguer, Frédéric |e investigator |4 oth | |
| 700 | 1 | |a Le Franc, Pierre |e investigator |4 oth | |
| 700 | 1 | |a Lecardonnel, Isabelle |e investigator |4 oth | |
| 700 | 1 | |a Fossati, Frederic |e investigator |4 oth | |
| 700 | 1 | |a Moubarak, Ghassan |e investigator |4 oth | |
| 700 | 1 | |a Mokrani, Omar Bilel |e investigator |4 oth | |
| 700 | 1 | |a Chavernac, Pascal |e investigator |4 oth | |
| 773 | 0 | 8 | |i Enthalten in |t Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology |d 1999 |g 25(2023), 5 vom: 19. Mai |w (DE-627)NLM111066492 |x 1532-2092 |7 nnns |
| 773 | 1 | 8 | |g volume:25 |g year:2023 |g number:5 |g day:19 |g month:05 |
| 856 | 4 | 0 | |u http://dx.doi.org/10.1093/europace/euad062 |3 Volltext |
| 912 | |a GBV_USEFLAG_A | ||
| 912 | |a GBV_NLM | ||
| 951 | |a AR | ||
| 952 | |d 25 |j 2023 |e 5 |b 19 |c 05 | ||