Targeting Hepatic Stellate Cell Death to Reverse Hepatic Fibrosis
Copyright© Bentham Science Publishers; For any queries, please email at epubbenthamscience.net..
To date, the incidence and mortality of chronic liver diseases such as cirrhosis and hepatocellular carcinoma due to the continued progression of hepatic fibrosis are increasing annually. Unfortunately, although a large number of studies have exhibited that some drugs have great potential for anti-fibrosis in animal and clinical trials, no specific anti-fibrosis drugs have been developed, and there is no better treatment for advanced cirrhosis than liver transplantation. It is a prevailing viewpoint that hepatic stellate cells (HSCs), as the mainstay of extracellular matrix secretion, are of great concern in the development of hepatic fibrosis. Therefore, targeting HSCs becomes extremely important to confront hepatic fibrosis. As previous studies described, inhibition of HSC activation and proliferation, induction of HSC death, and restoration of HSC quiescence are effective in reversing hepatic fibrosis. This review focuses on the current status of research on the treatment of hepatic fibrosis by inducing HSC death and elucidates the HSC death modes in detail and the crosstalk between them.
Medienart: |
E-Artikel |
---|
Erscheinungsjahr: |
2023 |
---|---|
Erschienen: |
2023 |
Enthalten in: |
Zur Gesamtaufnahme - volume:24 |
---|---|
Enthalten in: |
Current drug targets - 24(2023), 7 vom: 31., Seite 568-583 |
Sprache: |
Englisch |
---|
Beteiligte Personen: |
Zhang, Xiangting [VerfasserIn] |
---|
Links: |
---|
Themen: |
Apoptosis |
---|
Anmerkungen: |
Date Completed 14.07.2023 Date Revised 18.07.2023 published: Print Citation Status MEDLINE |
---|
doi: |
10.2174/1389450124666230330135834 |
---|
funding: |
|
---|---|
Förderinstitution / Projekttitel: |
|
PPN (Katalog-ID): |
NLM355046040 |
---|
LEADER | 01000naa a22002652 4500 | ||
---|---|---|---|
001 | NLM355046040 | ||
003 | DE-627 | ||
005 | 20231226063523.0 | ||
007 | cr uuu---uuuuu | ||
008 | 231226s2023 xx |||||o 00| ||eng c | ||
024 | 7 | |a 10.2174/1389450124666230330135834 |2 doi | |
028 | 5 | 2 | |a pubmed24n1183.xml |
035 | |a (DE-627)NLM355046040 | ||
035 | |a (NLM)36999702 | ||
040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
041 | |a eng | ||
100 | 1 | |a Zhang, Xiangting |e verfasserin |4 aut | |
245 | 1 | 0 | |a Targeting Hepatic Stellate Cell Death to Reverse Hepatic Fibrosis |
264 | 1 | |c 2023 | |
336 | |a Text |b txt |2 rdacontent | ||
337 | |a ƒaComputermedien |b c |2 rdamedia | ||
338 | |a ƒa Online-Ressource |b cr |2 rdacarrier | ||
500 | |a Date Completed 14.07.2023 | ||
500 | |a Date Revised 18.07.2023 | ||
500 | |a published: Print | ||
500 | |a Citation Status MEDLINE | ||
520 | |a Copyright© Bentham Science Publishers; For any queries, please email at epubbenthamscience.net. | ||
520 | |a To date, the incidence and mortality of chronic liver diseases such as cirrhosis and hepatocellular carcinoma due to the continued progression of hepatic fibrosis are increasing annually. Unfortunately, although a large number of studies have exhibited that some drugs have great potential for anti-fibrosis in animal and clinical trials, no specific anti-fibrosis drugs have been developed, and there is no better treatment for advanced cirrhosis than liver transplantation. It is a prevailing viewpoint that hepatic stellate cells (HSCs), as the mainstay of extracellular matrix secretion, are of great concern in the development of hepatic fibrosis. Therefore, targeting HSCs becomes extremely important to confront hepatic fibrosis. As previous studies described, inhibition of HSC activation and proliferation, induction of HSC death, and restoration of HSC quiescence are effective in reversing hepatic fibrosis. This review focuses on the current status of research on the treatment of hepatic fibrosis by inducing HSC death and elucidates the HSC death modes in detail and the crosstalk between them | ||
650 | 4 | |a Review | |
650 | 4 | |a Journal Article | |
650 | 4 | |a Research Support, Non-U.S. Gov't | |
650 | 4 | |a Hepatic stellate cells | |
650 | 4 | |a apoptosis | |
650 | 4 | |a autophagy | |
650 | 4 | |a cell death | |
650 | 4 | |a cellular senescence | |
650 | 4 | |a ferroptosis | |
650 | 4 | |a hepatic fibrosis | |
700 | 1 | |a Zeng, Yuan |e verfasserin |4 aut | |
700 | 1 | |a Zhao, Luying |e verfasserin |4 aut | |
700 | 1 | |a Xu, Qian |e verfasserin |4 aut | |
700 | 1 | |a Miao, Dan |e verfasserin |4 aut | |
700 | 1 | |a Yu, Fujun |e verfasserin |4 aut | |
773 | 0 | 8 | |i Enthalten in |t Current drug targets |d 2000 |g 24(2023), 7 vom: 31., Seite 568-583 |w (DE-627)NLM113669291 |x 1873-5592 |7 nnns |
773 | 1 | 8 | |g volume:24 |g year:2023 |g number:7 |g day:31 |g pages:568-583 |
856 | 4 | 0 | |u http://dx.doi.org/10.2174/1389450124666230330135834 |3 Volltext |
912 | |a GBV_USEFLAG_A | ||
912 | |a GBV_NLM | ||
951 | |a AR | ||
952 | |d 24 |j 2023 |e 7 |b 31 |h 568-583 |