Scalp cooling for the prevention of chemotherapy-induced alopecia : systematic review and meta-analysis.
OBJECTIVE: Alopecia is one of the most common adverse effects of chemotherapy, having a significant impact on the quality of life of patients who suffer from it. Among the interventions available for its prevention, scalp cooling (SC) is the most widely used. The aim of this study was to assess the efficacy and safety of the use of SC systems during chemotherapy sessions for the prevention or the reduction of the extent of chemotherapy-induced alopecia.
METHODS: A systematic review of the literature published up to November 2021 was carried out. Randomized clinical trials were selected. The main outcome measure was alopecia (hair loss>50%) during and after chemotherapy treatment. When possible, a quantitative synthesis of the results was performed through meta-analysis using the Stata v.15.0 software. The risk ratio (RR) of the variable alopecia, was estimated using a random effects model following the Mantel-Haenszel method. Statistical heterogeneity of the results was evaluated graphically and through the test of heterogeneity χ2 and the Higgins I2 statistic. Sensitivity analyses and subgroup analyses were performed.
RESULTS: 13 studies were included, with a total of 832 participants (97.7% women). In most studies, the main chemotherapy treatment applied was anthracyclines or the combination of anthracyclines and taxanes. The results obtained indicate that SC prevents alopecia (loss>50%) by 43% compared to the control group (RR=0.57; 95% CI=0.46 to 0.69; k=9; n=494; I2=63.8%). No statistically significant difference was found between the efficacy of automated and non-automated cooling systems (P=0.967). No serious short- or medium-term adverse events related to SC were recorded.
CONCLUSIONS: The results suggest that scalp cooling contributes to the prevention of chemotherapy-induced alopecia.
| Medienart: |
E-Artikel |
|---|
| Erscheinungsjahr: |
2023 |
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| Erschienen: |
2023 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:97 |
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| Enthalten in: |
Revista espanola de salud publica - 97(2023) vom: 29. März |
| Sprache: |
Spanisch |
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| Weiterer Titel: |
Enfriamiento del cuero cabelludo para la prevención de la alopecia secundaria a quimioterapia: revisión sistemática y metanálisis |
|---|
| Beteiligte Personen: |
Trujillo-Martín, María M [VerfasserIn] |
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| Themen: |
Alopecia |
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| Anmerkungen: |
Date Completed 03.04.2023 Date Revised 11.10.2023 published: Electronic Citation Status MEDLINE |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM355045672 |
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| 245 | 1 | 0 | |a Scalp cooling for the prevention of chemotherapy-induced alopecia |b systematic review and meta-analysis. |
| 246 | 3 | 3 | |a Enfriamiento del cuero cabelludo para la prevención de la alopecia secundaria a quimioterapia: revisión sistemática y metanálisis |
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| 500 | |a Date Completed 03.04.2023 | ||
| 500 | |a Date Revised 11.10.2023 | ||
| 500 | |a published: Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a OBJECTIVE: Alopecia is one of the most common adverse effects of chemotherapy, having a significant impact on the quality of life of patients who suffer from it. Among the interventions available for its prevention, scalp cooling (SC) is the most widely used. The aim of this study was to assess the efficacy and safety of the use of SC systems during chemotherapy sessions for the prevention or the reduction of the extent of chemotherapy-induced alopecia | ||
| 520 | |a METHODS: A systematic review of the literature published up to November 2021 was carried out. Randomized clinical trials were selected. The main outcome measure was alopecia (hair loss>50%) during and after chemotherapy treatment. When possible, a quantitative synthesis of the results was performed through meta-analysis using the Stata v.15.0 software. The risk ratio (RR) of the variable alopecia, was estimated using a random effects model following the Mantel-Haenszel method. Statistical heterogeneity of the results was evaluated graphically and through the test of heterogeneity χ2 and the Higgins I2 statistic. Sensitivity analyses and subgroup analyses were performed | ||
| 520 | |a RESULTS: 13 studies were included, with a total of 832 participants (97.7% women). In most studies, the main chemotherapy treatment applied was anthracyclines or the combination of anthracyclines and taxanes. The results obtained indicate that SC prevents alopecia (loss>50%) by 43% compared to the control group (RR=0.57; 95% CI=0.46 to 0.69; k=9; n=494; I2=63.8%). No statistically significant difference was found between the efficacy of automated and non-automated cooling systems (P=0.967). No serious short- or medium-term adverse events related to SC were recorded | ||
| 520 | |a CONCLUSIONS: The results suggest that scalp cooling contributes to the prevention of chemotherapy-induced alopecia | ||
| 650 | 4 | |a Meta-Analysis | |
| 650 | 4 | |a Systematic Review | |
| 650 | 4 | |a English Abstract | |
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Review | |
| 650 | 4 | |a Alopecia | |
| 650 | 4 | |a Chemotherapy | |
| 650 | 4 | |a Efficacy | |
| 650 | 4 | |a Safety | |
| 650 | 4 | |a Scalp cooling | |
| 650 | 4 | |a Spain | |
| 650 | 4 | |a Systematic review | |
| 650 | 7 | |a Anthracyclines |2 NLM | |
| 650 | 7 | |a Antineoplastic Agents |2 NLM | |
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| 700 | 1 | |a Abt-Sack, Analía |e verfasserin |4 aut | |
| 700 | 1 | |a Rueda Domínguez, Antonio |e verfasserin |4 aut | |
| 700 | 1 | |a Serrano-Aguilar, Pedro |e verfasserin |4 aut | |
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