Adaptive evolution of microorganisms based on industrial environmental perturbations
The development of synthetic biology has greatly promoted the construction of microbial cell factories, providing an important strategy for green and efficient chemical production. However, the bottleneck of poor tolerance to harsh industrial environments has become the key factor hampering the productivity of microbial cells. Adaptive evolution is an important method to domesticate microorganisms for a certain period by applying targeted selection pressure to obtain desired phenotypic or physiological properties that are adapted to a specific environment. Recently, with the development of technologies such as microfluidics, biosensors, and omics analysis, adaptive evolution has laid the foundation for efficient productivity of microbial cell factories. Herein, we discuss the key technologies of adaptive evolution and their important applications in improvement of environmental tolerance and production efficiency of microbial cell factories. Moreover, we looked forward to the prospects of adaptive evolution to realize industrial production by microbial cell factories.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2023 |
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| Erschienen: |
2023 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:39 |
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| Enthalten in: |
Sheng wu gong cheng xue bao = Chinese journal of biotechnology - 39(2023), 3 vom: 25. März, Seite 993-1008 |
| Sprache: |
Chinesisch |
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| Beteiligte Personen: |
Tang, Xiaoling [VerfasserIn] |
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| Links: |
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| Themen: |
Adaptive evolution |
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| Anmerkungen: |
Date Completed 31.03.2023 Date Revised 31.03.2023 published: Print Citation Status MEDLINE |
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| doi: |
10.13345/j.cjb.220781 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| 520 | |a The development of synthetic biology has greatly promoted the construction of microbial cell factories, providing an important strategy for green and efficient chemical production. However, the bottleneck of poor tolerance to harsh industrial environments has become the key factor hampering the productivity of microbial cells. Adaptive evolution is an important method to domesticate microorganisms for a certain period by applying targeted selection pressure to obtain desired phenotypic or physiological properties that are adapted to a specific environment. Recently, with the development of technologies such as microfluidics, biosensors, and omics analysis, adaptive evolution has laid the foundation for efficient productivity of microbial cell factories. Herein, we discuss the key technologies of adaptive evolution and their important applications in improvement of environmental tolerance and production efficiency of microbial cell factories. Moreover, we looked forward to the prospects of adaptive evolution to realize industrial production by microbial cell factories | ||
| 650 | 4 | |a English Abstract | |
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a adaptive evolution | |
| 650 | 4 | |a industrial environmental perturbation | |
| 650 | 4 | |a microbial cell factories | |
| 650 | 4 | |a production performance | |
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| 700 | 1 | |a Chen, Jingxiang |e verfasserin |4 aut | |
| 700 | 1 | |a Liu, Zhiqiang |e verfasserin |4 aut | |
| 700 | 1 | |a Zheng, Yuguo |e verfasserin |4 aut | |
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